Massachusetts is currently home to 3214 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy
NCT04288427
Recruiting
The study is being conducted to learn why some patients with Benign Prostatic Hyperplasia (BPH) do not respond to a commonly used treatment drug, Finasteride. The hope is to find ways to predict which patients will not respond to Finasteride so that, in the future, these patients can be identified prior to offering this treatment and they can be offered alternative treatment strategies in its place. The aim is to see if noninvasive techniques such as MRI can detect inflammation of the prostate t... Read More
Gender:
MALE
Ages:
50 years and above
Trial Updated:
03/27/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Benign Prostatic Hyperplasia, Prostate Hyperplasia, Prostate Disease, Prostate Hypertrophy, Prostate Pain, Lower Urinary Tract Symptoms, Urinary Obstruction, Urinary Tract Disease
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CERAMENT™| Bone Void Filler Device Registry
NCT04244942
Recruiting
A device registry to compile data on the performance of CERAMENT BONE VOID FILLER in normal use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Orthopedic Disorder
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Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy
NCT03286335
Recruiting
This research study is studying Proton Radiation as a possible treatment for brain tumor. The radiation involved in this study is: -Proton Radiation
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Brain Tumor
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A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders.
NCT05995873
Recruiting
Investigators will test, for safety and efficacy, a novel treatment for opiate addiction that applies a 4-minute treatment of intense near infra-red light to stimulate a side of the brain that the investigators determine to be healthier, more mature, and less traumatized. Investigators will compare among actively using participants an active and a sham treatment given either once or twice weekly for 25-weeks at 2 sites. Investigators hope this will lead to a significant weapon in the battle agai... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/24/2024
Locations: MindLight, LLC, Newton Highlands, Massachusetts
Conditions: Opioid Use Disorder, Moderate, Opioid Use, Opioid Dependence, Opioid Abuse, Opiate Dependence, Opioid Use, Unspecified
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Translation of Robotic Apparel for Alleviating Low Back Pain
NCT05736393
Recruiting
This is a NIAMS-sponsored clinical trial being conducted through the NIH Helping to End Addition Long-term (HEAL) Initiative's Back Pain Consortium (BACPAC) Research Program. This is a single-arm controlled trial with individuals aged 18-70 with low back pain (LBP). This study investigates the effect(s) of augmenting physical therapy (PT) interventions with the use of an experimental wearable soft robotic device ('exosuit').
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/20/2024
Locations: Boston University Physical Therapy Center, Boston, Massachusetts
Conditions: Low Back Pain
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The CALERIE™ Legacy Study
NCT05651620
Recruiting
The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was conducted from 2007 to 2011.
Gender:
ALL
Ages:
Between 33 years and 70 years
Trial Updated:
03/20/2024
Locations: Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
Conditions: Calorie Restriction
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Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
NCT04296604
Recruiting
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Attention Deficit Hyperactivity Disorder, Borderline Personality Disorder, Substance Use Disorders
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Neuromodulation of Executive Function in the ADHD Brain
NCT04175028
Recruiting
This study aims to determine the transient, modulatory effects of transcranial direct current stimulation (tDCS) on executive function and inhibitory control in patients with ADHD compared to healthy controls.
Gender:
ALL
Ages:
Between 18 years and 66 years
Trial Updated:
03/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Attention Deficit Hyperactivity Disorder
Register for Updates
Study of the Role of Genetic Modifiers in Hemoglobinopathies
NCT05799118
Recruiting
This study will investigate the role of genetic modifiers in hemoglobinopathies through a large-scale, multi-ethnic genome-wide association study (GWAS).
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/19/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Sickle Cell Disease, Thalassemia, Beta, Thalassemia Alpha, Hemoglobinopathies
Register for Updates
Decompression Versus Decompression and Fusion
NCT04542720
Recruiting
Adjacent segment disease (ASD) in the lumbar spine is a well-known sequela of lumbar fusion surgery. The annual incidence of adjacent level re-operation is approximately 3% with a ten-year prevalence of 20-30%. Frequently, the surgical treatment involves decompression of the adjacent level coupled with extension of the instrumentation and fusion. Advocates of this paradigm cite the altered kinematics and biomechanics of levels adjacent to a lumbar fusion mass. Furthermore, decompressed levels ad... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Adjacent Segment Disease
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Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer
NCT03803553
Recruiting
This research study is comparing two standard of care treatment options based on blood test results for participants who have metastatic colon cancer. The names of the potential treatments involved in this study are: * Active surveillance * FOLFIRI treatment * Nivolumab treatment * Encorafenib/Binimetinib/Cetuximab treatment * Trastuzumab + Pertuzumab
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Metastatic Colon Cancer, Stage III Colon Cancer
Register for Updates
Metastatic Tumor Research and Outcomes Network
NCT02830451
Recruiting
The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with metastatic spine tumor(s).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Harvard Medical School Department of Neurosurgery, Boston, Massachusetts
Conditions: Metastatic Spine Tumor
Register for Updates