Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy
NCT05003648
Recruiting
The investigators recently observed that up to 25% of women with X-linked adrenoleukodystrophy (ALD) have moderate to severe Restless Leg Syndrome (RLS). In this study, the investigators aim to estimate the prevalence of RLS among women with ALD and to assess whether pramipexole improves RLS symptoms as well as sleep and gait measures in women with ALD.
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
04/02/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Adrenoleukodystrophy, Restless Legs Syndrome
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Ultrasound Guided Femoral Nerve Block
NCT02381717
Recruiting
The goal of the study is to evaluate whether pain control achieved by Ultrasound Guided Femoral Nerve Blockade (USFNB) is equal in efficacy to standard pain management practice of parenteral injection of opioid pain medication in patients presenting to the emergency department (ED) with hip fracture.
Gender:
ALL
Ages:
Between 18 years and 101 years
Trial Updated:
04/02/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Hip Fracture
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Hematoma Block for Distal Radius Fracture
NCT02346929
Recruiting
The purpose of this study is to determine the efficacy of ultrasound guided hematoma block versus traditional "blind" hematoma block for analgesia in distal radius fracture reduction.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/02/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Distal Radius Fracture
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Transcranial Direct Current Stimulation (tDCS) in Pediatric Obsessive Compulsive Disorder (OCD)
NCT04548609
Recruiting
In this study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in modulating aberrant neurocognitive processes implicated in pediatric patients with obsessive compulsive disorder (OCD).
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
04/01/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Obsessive-Compulsive Disorder, Pediatric Psychiatric Disorder
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Niraparib In Recurrent IDH 1/2 Gliomas
NCT05406700
Recruiting
This is a randomized, two-arm, open-label, phase 0 trial to assess intratumoral pharmacokinetics and pharmacodynamics of niraparib in subjects with progressive IDH1 or IDH2 mutant glioma. - This research study involves an experimental treatment called Niraparib.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Low-grade Glioma, IDH2 Gene Mutation, Recurrent Glioma, IDH1 Mutation, Glioma, Malignant
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Determination and Validation of a Multi-analyte Assay for Lung Cancer Screening
NCT04968548
Recruiting
This study is part of the development and validation of a non-invasive lung screening test which aim to identify early stage lung cancer in patients at high risk for lung cancer.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
03/28/2024
Locations: Lahey Hospital and Medical Center, Burlington, Massachusetts
Conditions: Lung Cancer
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ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas
NCT03922555
Recruiting
this research study is evaluating the highest dose of ASTX727 that can be administered safely to recurrent/progressive non-enhancing IDH mutant gliomas patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Neurological Cancer
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5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy
NCT04288427
Recruiting
The study is being conducted to learn why some patients with Benign Prostatic Hyperplasia (BPH) do not respond to a commonly used treatment drug, Finasteride. The hope is to find ways to predict which patients will not respond to Finasteride so that, in the future, these patients can be identified prior to offering this treatment and they can be offered alternative treatment strategies in its place. The aim is to see if noninvasive techniques such as MRI can detect inflammation of the prostate t... Read More
Gender:
MALE
Ages:
50 years and above
Trial Updated:
03/27/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Benign Prostatic Hyperplasia, Prostate Hyperplasia, Prostate Disease, Prostate Hypertrophy, Prostate Pain, Lower Urinary Tract Symptoms, Urinary Obstruction, Urinary Tract Disease
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CERAMENT™| Bone Void Filler Device Registry
NCT04244942
Recruiting
A device registry to compile data on the performance of CERAMENT BONE VOID FILLER in normal use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Orthopedic Disorder
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A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders.
NCT05995873
Recruiting
Investigators will test, for safety and efficacy, a novel treatment for opiate addiction that applies a 4-minute treatment of intense near infra-red light to stimulate a side of the brain that the investigators determine to be healthier, more mature, and less traumatized. Investigators will compare among actively using participants an active and a sham treatment given either once or twice weekly for 25-weeks at 2 sites. Investigators hope this will lead to a significant weapon in the battle agai... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/24/2024
Locations: MindLight, LLC, Newton Highlands, Massachusetts
Conditions: Opioid Use Disorder, Moderate, Opioid Use, Opioid Dependence, Opioid Abuse, Opiate Dependence, Opioid Use, Unspecified
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Translation of Robotic Apparel for Alleviating Low Back Pain
NCT05736393
Recruiting
This is a NIAMS-sponsored clinical trial being conducted through the NIH Helping to End Addition Long-term (HEAL) Initiative's Back Pain Consortium (BACPAC) Research Program. This is a single-arm controlled trial with individuals aged 18-70 with low back pain (LBP). This study investigates the effect(s) of augmenting physical therapy (PT) interventions with the use of an experimental wearable soft robotic device ('exosuit').
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/20/2024
Locations: Boston University Physical Therapy Center, Boston, Massachusetts
Conditions: Low Back Pain
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The CALERIE™ Legacy Study
NCT05651620
Recruiting
The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was conducted from 2007 to 2011.
Gender:
ALL
Ages:
Between 33 years and 70 years
Trial Updated:
03/20/2024
Locations: Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
Conditions: Calorie Restriction
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