Colorado is currently home to 1786 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Add-on Reparixin in Adult Patients With ARDS
NCT05496868
Recruiting
Study objectives 1. To characterize the efficacy of reparixin in ameliorating lung injury and systemic inflammation and expediting clinical recovery and liberation from mechanical ventilation in adult patients with moderate to severe ARDS (PaO2/FIO2 ratio ≤ 200). 2. to assess the effect of reparixin on systemic biomarkers linked to a hyper-inflammatory ARDS phenotype. 3. To evaluate the safety of reparixin vs. placebo in patients enrolled in the study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Denver Health, Denver, Colorado
Conditions: Acute Respiratory Distress Syndrome, Adult
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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
NCT06129864
Recruiting
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
10/02/2024
Locations: Research Site, Aurora, Colorado
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
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BiPAP in Pediatric Moderate to Severe Asthma Randomized Control Trial
NCT05848115
Recruiting
The goal of this clinical trial is to study if starting bi-level positive airway pressure (BiPAP), a mask that gives pressure to the lungs, works well for children in the emergency department with moderate to severe asthma attacks. The main questions it aims to answer are: 1. Whether initiation of BiPAP at the same time as continuous beta-agonist therapy (e.g., nebulized albuterol) will decrease how long children with moderate to severe asthma attacks need to receive continuous beta-agonist the... Read More
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
10/02/2024
Locations: Childrens Hospital Colorado, Denver, Colorado
Conditions: Asthma in Children
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The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy
NCT04394806
Recruiting
This study plans to learn more about how triglyceride levels in pregnancy affect newborn fat mass. Obesity in pregnancy, in the absence of gestational diabetes, is now the most common cause of large-for-gestational-age infants and increased newborn fat mass. Previous data supports the idea that maternal triglycerides, not glucose, are the strongest predictor of both total newborn fat mass and liver fat. In this study, mothers will monitor triglyceride and glucose levels at specific points in pre... Read More
Gender:
ALL
Ages:
Between 0 years and 39 years
Trial Updated:
10/02/2024
Locations: University of Colorado/Anschutz Medical Campus, Aurora, Colorado
Conditions: Pregnancy
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Therapeutic Omegas for Triglyceride Suppression
NCT04349475
Recruiting
This study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. Triglycerides are a type of fat found in your blood. Your body converts extra calories into triglycerides to be stored and used later for energy. It is normal for triglyceride levels to go up during pregnancy however some women have levels that are \~30-40% higher than normal when they reach their third trimester of pregnancy. Having high triglycerides in pregnancy may be related t... Read More
Gender:
ALL
Ages:
Between 0 years and 39 years
Trial Updated:
10/02/2024
Locations: University of Colorado/Anschutz Medical Campus, Aurora, Colorado
Conditions: Pregnancy
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Non-invasive Evaluation of Upper and Lower Body Function With Showmotion
NCT04137835
Recruiting
It is very important to understand joint and body kinematics and muscles activity in clinical settings, which is relevant to identify issues related to the spine, the upper and lower limbs due to injury. In this study, the investigators will use an innovative platform, Showmotion to establish baseline of shoulder, hip, knee and spine kinematics and muscles activity from 60 healthy volunteers.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/02/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Osteoarthritis, Hip, Osteoarthritis, Knee, Osteoarthritis, Spine
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Phase 1b Combo w/ Ribociclib, Alpelisib, or Everolimus
NCT05508906
Recruiting
This is a Phase 1b open-label, 2-part study in 3 treatment groups. The 3 treatment groups are as follows: Treatment Group 1: OP-1250 in combination with ribociclib (KISQALI®, Novartis Pharmaceuticals Corporation). Treatment Group 2: OP-1250 in combination with alpelisib (PIQRAY®, Novartis Pharmaceuticals Corporation). Treatment Group 3: OP-1250 in combination with everolimus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: University of Colorado Cancer Center, Aurora, Colorado
Conditions: Metastatic Breast Cancer, Advanced Breast Cancer, HER2-negative Breast Cancer, ER-positive Breast Cancer, Breast Cancer
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ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk
NCT05064553
Recruiting
The primary objective is to assess overall sensitivity and specificity of Oncoguard™ Liver for hepatocellular cancer (HCC) detection in a surveillance population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: Rocky Mountain Gastroenterology, Littleton, Colorado
Conditions: Hepatocellular Carcinoma, Hepatocellular Cancer, Hepatitis B, Cirrhosis, Liver Cancer
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SMR Stemless Reverse Vs SMR Reverse Shoulder System
NCT04697004
Recruiting
The SMR Stemless Reverse is intended for total, primary shoulder joint replacement by reducing pain and restoring shoulder articular mobility function. This is a prospective, multi-center, randomized, controlled trial to demonstrate non-inferiority of the SMR Stemless Reverse to the SMR Reverse Shoulder System. Patients with joint dysfunction who continue to experience significant symptoms despite an appropriate course of non-operative management are eligible. Patients will be considered enroll... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/01/2024
Locations: Western Orthopaedics, Denver, Colorado
Conditions: Arthroplasty, Replacement
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Personalized Spine Study Group (PSSG) Registry
NCT04601363
Recruiting
The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods. The secondary objective is to collect clinical and radiographic outcomes of patients with hardware as a control cohort to the patient-specific rods.
Gender:
ALL
Ages:
Between 10 years and 85 years
Trial Updated:
10/01/2024
Locations: Dr. Christopher Kleck, MD, Aurora, Colorado
Conditions: Scoliosis; Adolescence, Degenerative Disc Disease, Spinal Fusion, Kyphoscoliosis, Pseudoarthrosis of Spine, Spinal Stenosis, Kyphoses, Scheuermann
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CBD for Individuals at Risk for Alzheimer's Disease
NCT05822362
Recruiting
This is a double-blind, randomized controlled trial designed to test the effects of cannabidiol (CBD) on validated biomarkers of Alzheimer's disease (AD) progression, and behavioral, neurocognitive, and clinical measures, with putative mechanisms of action.
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
09/27/2024
Locations: University of Colorado - Anschutz Medical Campus, Aurora, Colorado
Conditions: Mild Cognitive Impairment
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Alcohol Use Disorder and Cannabidiol
NCT05613608
Recruiting
This is a double-blind, placebo-controlled, parallel group study designed to assess the efficacy of full spectrum CBD and broad spectrum CBD, compared to a placebo control (PC), to reduce drinking in participants with alcohol use disorder. If eligible for the study, subjects will be randomized to receive one of the conditions for 12 weeks.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
09/27/2024
Locations: University of Colorado Anschutz, Aurora, Colorado
Conditions: Alcohol Use Disorder
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