Colorado is currently home to 1808 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
NCT02480283
Recruiting
This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
10/07/2024
Locations: University of Colorado, Denver, Aurora, Colorado
Conditions: Cannabis Smoking, Oxidative Stress
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Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
NCT02299921
Recruiting
This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease. When it happens, the lungs have trouble carrying out their normal function of getting oxygen into the blood, and removing carbon dioxide from the body. Investigators are conducting this study to see what drinking too much alcohol, using tobacco products, or using drugs (both legal and illegal) may do to... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/07/2024
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Infection, Alcohol Abuse, Drugs of Abuse, Lung Injury
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Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients with Inflammatory or Invasive Breast Cancer
NCT00477100
Recruiting
This trial studies the biospecimen and medical data collection in creating a research tissue registry in patients with inflammatory or invasive breast cancer. Collecting medical data and storing samples of blood, tissue, and stool from patients with inflammatory breast cancer to study in the laboratory may help doctors find better ways to treat and study inflammatory breast cancer in the future.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Banner - MD Anderson Cancer Center - Northern Colorado, Greeley, Colorado
Conditions: Inflammatory Breast Carcinoma, Invasive Breast Carcinoma, Second Primary Malignant Neoplasm
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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
NCT06129864
Recruiting
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
10/02/2024
Locations: Research Site, Aurora, Colorado
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Register for Updates
BiPAP in Pediatric Moderate to Severe Asthma Randomized Control Trial
NCT05848115
Recruiting
The goal of this clinical trial is to study if starting bi-level positive airway pressure (BiPAP), a mask that gives pressure to the lungs, works well for children in the emergency department with moderate to severe asthma attacks. The main questions it aims to answer are: 1. Whether initiation of BiPAP at the same time as continuous beta-agonist therapy (e.g., nebulized albuterol) will decrease how long children with moderate to severe asthma attacks need to receive continuous beta-agonist the... Read More
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
10/02/2024
Locations: Childrens Hospital Colorado, Denver, Colorado
Conditions: Asthma in Children
Register for Updates
The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy
NCT04394806
Recruiting
This study plans to learn more about how triglyceride levels in pregnancy affect newborn fat mass. Obesity in pregnancy, in the absence of gestational diabetes, is now the most common cause of large-for-gestational-age infants and increased newborn fat mass. Previous data supports the idea that maternal triglycerides, not glucose, are the strongest predictor of both total newborn fat mass and liver fat. In this study, mothers will monitor triglyceride and glucose levels at specific points in pre... Read More
Gender:
ALL
Ages:
Between 0 years and 39 years
Trial Updated:
10/02/2024
Locations: University of Colorado/Anschutz Medical Campus, Aurora, Colorado
Conditions: Pregnancy
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Therapeutic Omegas for Triglyceride Suppression
NCT04349475
Recruiting
This study plans to learn more about how an omega-3 fatty acid supplement effects triglyceride levels in pregnancy. Triglycerides are a type of fat found in your blood. Your body converts extra calories into triglycerides to be stored and used later for energy. It is normal for triglyceride levels to go up during pregnancy however some women have levels that are \~30-40% higher than normal when they reach their third trimester of pregnancy. Having high triglycerides in pregnancy may be related t... Read More
Gender:
ALL
Ages:
Between 0 years and 39 years
Trial Updated:
10/02/2024
Locations: University of Colorado/Anschutz Medical Campus, Aurora, Colorado
Conditions: Pregnancy
Register for Updates
Non-invasive Evaluation of Upper and Lower Body Function With Showmotion
NCT04137835
Recruiting
It is very important to understand joint and body kinematics and muscles activity in clinical settings, which is relevant to identify issues related to the spine, the upper and lower limbs due to injury. In this study, the investigators will use an innovative platform, Showmotion to establish baseline of shoulder, hip, knee and spine kinematics and muscles activity from 60 healthy volunteers.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/02/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Osteoarthritis, Hip, Osteoarthritis, Knee, Osteoarthritis, Spine
Register for Updates
Phase 1b Combo w/ Ribociclib, Alpelisib, or Everolimus
NCT05508906
Recruiting
This is a Phase 1b open-label, 2-part study in 3 treatment groups. The 3 treatment groups are as follows: Treatment Group 1: OP-1250 in combination with ribociclib (KISQALI®, Novartis Pharmaceuticals Corporation). Treatment Group 2: OP-1250 in combination with alpelisib (PIQRAY®, Novartis Pharmaceuticals Corporation). Treatment Group 3: OP-1250 in combination with everolimus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: University of Colorado Cancer Center, Aurora, Colorado
Conditions: Metastatic Breast Cancer, Advanced Breast Cancer, HER2-negative Breast Cancer, ER-positive Breast Cancer, Breast Cancer
Register for Updates
SMR Stemless Reverse Vs SMR Reverse Shoulder System
NCT04697004
Recruiting
The SMR Stemless Reverse is intended for total, primary shoulder joint replacement by reducing pain and restoring shoulder articular mobility function. This is a prospective, multi-center, randomized, controlled trial to demonstrate non-inferiority of the SMR Stemless Reverse to the SMR Reverse Shoulder System. Patients with joint dysfunction who continue to experience significant symptoms despite an appropriate course of non-operative management are eligible. Patients will be considered enroll... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/01/2024
Locations: Western Orthopaedics, Denver, Colorado
Conditions: Arthroplasty, Replacement
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Personalized Spine Study Group (PSSG) Registry
NCT04601363
Recruiting
The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods. The secondary objective is to collect clinical and radiographic outcomes of patients with hardware as a control cohort to the patient-specific rods.
Gender:
ALL
Ages:
Between 10 years and 85 years
Trial Updated:
10/01/2024
Locations: Dr. Christopher Kleck, MD, Aurora, Colorado
Conditions: Scoliosis; Adolescence, Degenerative Disc Disease, Spinal Fusion, Kyphoscoliosis, Pseudoarthrosis of Spine, Spinal Stenosis, Kyphoses, Scheuermann
Register for Updates
CBD for Individuals at Risk for Alzheimer's Disease
NCT05822362
Recruiting
This is a double-blind, randomized controlled trial designed to test the effects of cannabidiol (CBD) on validated biomarkers of Alzheimer's disease (AD) progression, and behavioral, neurocognitive, and clinical measures, with putative mechanisms of action.
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
09/27/2024
Locations: University of Colorado - Anschutz Medical Campus, Aurora, Colorado
Conditions: Mild Cognitive Impairment
Register for Updates