Colorado is currently home to 1784 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Effects of High Altitude on AMPK Activation
NCT02391519
Recruiting
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arter... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
06/07/2024
Locations: University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado
Conditions: Pregnancy, IUGR, Preeclampsia
Register for Updates
Depression & Insulin Sensitivity in Adolescents
NCT03263351
Recruiting
There has been a rise in type 2 diabetes (T2D) rates in adolescents, disproportionately in girls from disadvantaged racial/ethnic groups. This group of girls also is at heightened risk for depression, and depression and T2D are linked. Depressive symptoms are a risk factor for worsening of insulin sensitivity, one if the major precursors to T2D. In preliminary studies, the investigators found that a brief cognitive-behavioral therapy group decreased depressive symptoms and prevented worsening of... Read More
Gender:
FEMALE
Ages:
Between 12 years and 17 years
Trial Updated:
06/06/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance, Depression, Adolescent Obesity
Register for Updates
Evaluation of a Decision Aid for Deep Brain Stimulation Surgery for Parkinson's Disease
NCT06446505
Recruiting
The goal of this clinical trial is to learn if a Decision Aid can help patients with Parkinson's disease make a decision about undergoing Deep Brain Stimulation surgery. The main questions it aims to answer are: * Is the Decision Aid acceptable to patients with Parkinson's disease considering Deep Brain Stimulation surgery? * Does the decision aid improve decision quality (informed, value-based decision) and uncertainty about the decision? Researchers will compare immediate use of the decision... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: University of Colorado Anschutz, Aurora, Colorado
Conditions: Parkinson Disease
Register for Updates
A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI
NCT06238492
Recruiting
This study seeks conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
06/04/2024
Locations: Craig Hospital, Englewood, Colorado
Conditions: Spinal Cord Injuries, Cognitive Dysfunction, Cognitive Impairment, Acute Spinal Cord Injury
Register for Updates
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
NCT05822609
Recruiting
The primary objective of this study is to determine the effects of semaglutide on kidney oxygenation and function in type 1 diabetes. The secondary objective is to determine the glycemic effects and safety of semaglutide in type 1 diabetes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Diabetic Kidney Disease, Type 1 Diabetes
Register for Updates
Primary Sclerosing Cholangitis in Children
NCT04181138
Recruiting
Primary sclerosing cholangitis (PSC) is a rare liver disease that damages the liver's bile ducts. Bile ducts are tiny tubes that carry bile from the liver to the small intestine. Bile is a liquid produced by the liver that helps us absorb and use the nutrients in the food we eat. In people with PSC, the bile backs up into the liver and will damage it, causing scarring of the liver. The purposes of this study are to: * Collect medical and other data to learn more about PSC, how it progresses, a... Read More
Gender:
ALL
Ages:
Between 2 years and 25 years
Trial Updated:
06/04/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Primary Sclerosing Cholangitis, Liver Diseases, Cholangitis, Sclerosing
Register for Updates
Biliary Atresia Study in Infants and Children
NCT00345553
Recruiting
Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA; To identify polymorphisms that may be important in disease progression such as HLA polymorphisms; To characterize the natural history of the older, non-... Read More
Gender:
ALL
Ages:
Between 6 months and 20 years
Trial Updated:
06/04/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Biliary Atresia
Register for Updates
A Prospective Database of Infants With Cholestasis
NCT00061828
Recruiting
Biliary atresia, idiopathic neonatal hepatitis, and specific genetic cholestatic conditions are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Childhood Liver Disease Research Network (ChiLDReN) is to establish a database of clinical information and plasma, serum, and tissue samples from cholestatic children to facilitate research and to perform clinical, epidemiological and therapeutic trials in these important pediat... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
06/04/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Biliary Atresia, Neonatal Cholestasis
Register for Updates
OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier
NCT06447844
Recruiting
The study will be a multi-site, randomized, two-arm, controlled clinical trial using OsteoGen® Plug (Test) vs Freeze-dried Bone Allograft with collagen barrier (Control) for alveolar ridge preservation (ARP) in posterior extraction sites with intact buccal cortical plates.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/03/2024
Locations: McClain and Schallhorn Periodontics and Implant Dentistry, Aurora, Colorado
Conditions: Nonterminal Premolar Needing Extraction
Register for Updates
Eliminating Monitor Overuse Trial (EMO Trial)
NCT05132322
Recruiting
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/03/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Bronchiolitis Acute Viral
Register for Updates
A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction
NCT03776162
Recruiting
This study is designed to evaluate bridge-enhanced ACL restoration (BEAR), a new surgical technique for repairing knees injured by a tear of the anterior cruciate ligament (ACL) that promotes reattachment and healing of the ACL using a blood-enriched implant. BEAR will be compared to bone to patellar tendon to bone autograft (BPTB) reconstruction, a standard ACL surgical reconstruction technique that replaces a torn portion of the ACL with transplanted patellar tendon tissue, and thus requires a... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/31/2024
Locations: University of Colorado, Boulder, Colorado
Conditions: Anterior Cruciate Ligament Tear
Register for Updates
Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)
NCT04197596
Recruiting
BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be safe and effective in decreasing specific viral load in children, adolescents and young adults (CAYA) with refractory BK infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) or with primary immunodeficiencies (PID).
Gender:
ALL
Ages:
Between 1 month and 79 years
Trial Updated:
05/30/2024
Locations: Children's Hospital of Colorado, Aurora, Colorado
Conditions: Viral Infection, Primary Immune Deficiency Disorder
Register for Updates