Colorado is currently home to 1810 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Denver, Aurora, Colorado Springs and Englewood. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients
NCT05637216
Recruiting
This study will evaluate the efficacy of losartan (LOS), an FDA-approved transforming growth factor beta-1 (TGF-β1) blocker, to decrease radiation induced fibrosis (RIF) in the breast and the lung of breast cancer patients, testing the hypothesis that Losartan will decrease RIF, TGF- β1 and cellular senescence/inflammation in the breast and the lung of irradiated breast cancer patients relative to placebo treatment and consequently improve clinical outcomes in breast cancer patients.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: Vail Health Shaw Cancer Center, Edwards, Colorado
Conditions: Radiation Induced Fibrosis
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Epilepsy Learning Healthcare System (ELHS)
NCT06265103
Recruiting
The Epilepsy Learning Health System (ELHS) is a quality improvement and research network to improve outcomes for people with epilepsy. The ELHS is designed as a model of value-based chronic care for epilepsy as envisioned by the National Academies of Medicine Committee in their landmark reports "The Learning Health System" and "Epilepsy Across the Spectrum: Promoting Health and Understanding". The ELHS network is a collaboration among clinicians, patients and researchers that promotes the use o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/28/2024
Locations: UC Health University of Colorado Anshutz, Aurora, Colorado
Conditions: Epilepsy, Seizure Disorder, Neurologic Disorder, Rare Diseases
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Use of Incentives for Stressful Medical Procedures
NCT06254898
Recruiting
The goal of this clinical trial is to learn about the use of incentives in pediatric patients requiring medical procedures. The main questions it aims to answer are: * Are incentives effective at reducing pediatric anxiety for medical procedures? * What is the best way to use incentives with pediatric populations requiring medical procedures? Participants will be provided support in preparation for their procedure and during the procedure by a child life specialist and might receive an incentiv... Read More
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
08/28/2024
Locations: Children's Hospital Colorado Anschutz, Aurora, Colorado
Conditions: Healthy
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Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
NCT00900419
Recruiting
RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patients with respiratory tract dysplasia or lung cancer, head and neck cancer, or aerodigestive tract cancer.
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
08/28/2024
Locations: University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado
Conditions: Esophageal Cancer, Head and Neck Cancer, Lung Cancer, Precancerous Condition
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Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma
NCT04756726
Recruiting
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of oral cemsidomide (also known as CFT7455) administered at different dosages in subjects with Relapsed/Refractory (r/r) Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM). Cemsidomide may be administered as a single agent and, in MM only, in combination with oral dexamethasone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: Colorado Blood Cancer Institute (Sarah Cannon Research Institute), Denver, Colorado
Conditions: Multiple Myeloma, Lymphoma, Non-Hodgkin's
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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/27/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
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The APS Phenotyping Study
NCT06521502
Recruiting
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will be available to investigators for future studies of ARDS, sepsis, and/or pneumonia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: University of Colorado, Denver, Denver, Colorado
Conditions: ARDS, Sepsis, Pneumonia
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A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)
NCT06305234
Recruiting
This is a 10-year multi-center, prospective, longitudinal, single arm study evaluating immunologic, inflammatory and laboratory parameters associated with long-term Palynziq treatment in subjects with phenylketonuria (PKU) in the United States (US). Subjects in the US for whom a clinical decision has been made that they will receive pegvaliase to treat their PKU within 30 days following the date of enrollment in Study 165-501 (incident-users) or who have previously started treatment with pegvali... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/23/2024
Locations: University of Colorado, Aurora, Colorado
Conditions: Phenylketonuria (PKU)
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An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis
NCT05505981
Recruiting
Spondylolysis, a stress fracture in the pars interarticularis of a lumbar vertebra, is the most common identifiable cause of low back pain (LBP) in adolescent athletes, occurring in 14-30% of athletes who experience LBP. Spondylolysis can cause significant pain and disability and months of exclusion from sports or an active lifestyle. Standard care of spondylolysis in adolescent athletes is primarily based on expert opinion, with dramatic variations in clinical practice, including restrictive br... Read More
Gender:
ALL
Ages:
Between 10 years and 19 years
Trial Updated:
08/23/2024
Locations: Children's Hospital of Colorado, Denver, Colorado
Conditions: Lumbar Spondylosis
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PCOM2 - The Physician Communication Intervention, Version 2.0
NCT05336240
Recruiting
Poor quality of primary care providers' vaccine recommendations lead to low adolescent human papillomavirus vaccination rates and hundreds of thousands of adolescents unnecessarily at risk for HPV-associated cancers and diseases. Though a previous provider communication intervention, called PCOM, was found to be effective for increasing adolescent HPV vaccination in primary care, its dissemination is limited by the need for significant research team involvement to teach providers how to use the... Read More
Gender:
ALL
Ages:
Between 9 years and 17 years
Trial Updated:
08/22/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: HPV Infection, Preventive Health Services
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Acute Equol Supplementation and Vascular Function in Women With and Without CKD
NCT06128278
Recruiting
The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in nephrology focuses on male patients, and studies on women's vascular health are limited. Establishing effective therapies for improving vascular function and reducing CVD risk in women with CKD... Read More
Gender:
FEMALE
Ages:
Between 50 years and 69 years
Trial Updated:
08/21/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Chronic Kidney Diseases
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Sex Hormone and Vascular Function in Women With CKD
NCT05471518
Recruiting
The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in the field of nephrology focuses on male patients, and studies on women's vascular health are limited. Moreover, endogenous sex hormones, particularly estradiol, are well-documented to be cardiop... Read More
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Chronic Kidney Diseases
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