There are currently 241 active clinical trials seeking participants for Healthy research studies. The states with the highest number of trials for Healthy participants are California, Florida, Texas and Maryland.
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
NCT06874205
Recruiting
Background: PDE4D is a protein in the body that plays a role in thinking and depression. This protein may play a major role in disorders such as Alzheimer disease or major depressive disorder. To learn more about these disorders, researchers want to be able to detect levels of PDE4D in the brain. 11C-JMJ-129 is a new radiotracer (a radioactive substance that highlights parts of the body during imaging scans) that was developed to attach only to PDE4D. Objective: To test the new radiotracer 11... Read More
Gender:
ALL
Ages:
Between 18 years and 101 years
Trial Updated:
05/30/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy
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Multifocal HD-tDCS and Motor Function
NCT06561165
Recruiting
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS. The hypothesis is that dexterous hand function will improve after a standard HD-tDCS... Read More
Gender:
ALL
Ages:
Between 65 years and 85 years
Trial Updated:
05/30/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Healthy
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Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion
NCT05264727
Recruiting
This study is being done to better understand how amino acids alter the release of glucagon and insulin compared to glucose alone in health and disease.
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
05/30/2025
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Healthy, Type 2 Diabetes, Obesity
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SV2A Density Cannabis Use Disorder
NCT05472818
Recruiting
The main purpose of this study is to determine whether hippocampal synaptic vesicle density estimated by hippocampal \[11C\]APP-311/\[11C\]UCB-J binding in individuals diagnosed with cannabis use disorder (CUDs) improves with at least 4 weeks of confirmed abstinence from cannabis, in comparison to healthy controls (HCs). Furthermore, any change in synaptic vesicle density will be placed in functional context by measuring verbal memory, which is sensitive to hippocampal function, before and after... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/29/2025
Locations: Yale University School of Medicine, New Haven, Connecticut
Conditions: Cannabis Use Disorder, Healthy
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Cell Free DNA in Cardiac Sarcoidosis
NCT03858777
Recruiting
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality. Immunosuppressive therapy (IST) has been shown to reverse active myocarditis and preserve left ventricular (LV) function and in some cases improve LV function. In addition, IST can suppress arrhythmias that develop due to active myocardi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2025
Locations: University of Iowa, Iowa City, Iowa +1 locations
Conditions: Sarcoidosis With Myocarditis, Sarcoidosis, Healthy, ST Elevation Myocardial Infarction
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Improving Night Shift Nurses' Health and Reducing Burnout
NCT06829979
Recruiting
Healthy and happy nurses are essential to ensuring optimal patient outcomes and organizational success. The evidence on the negative impacts of night shift on nurses' health and cognitive function, and their implications on patient outcomes and organizational costs, reflect the need for interventions to mitigate these detrimental outcomes. This pilot, feasibility, clinical trial will examine the feasibility of two fatigue countermeasure interventions (access to napping/relaxation room and use o... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/27/2025
Locations: UPMC Shadyside, Pittsburgh, Pennsylvania
Conditions: Healthy
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Resident Posture Biofeedback Study
NCT06564519
Recruiting
While a majority of surgical ergonomic studies have been evaluating attending surgeons, few have evaluated surgical ergonomics within the surgical resident. Biofeedback devices can be partnered with education and geared towards surgical residents to decrease current and future musculoskeletal disorders, which may in turn lead to longer and more fulfilling careers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Postural; Strain, Healthy
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Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
NCT05219799
Recruiting
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
05/22/2025
Locations: University of Missouri, Columbia, Missouri
Conditions: Obesity, Vasodilation, Healthy
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Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib
NCT06997276
Recruiting
The purposes of this study are to determine: * The pharmacokinetics (the amount of study drug in your blood and how long it takes the body to get rid of it) of the study drug and its metabolites (substances produced as the body breaks down the study drug) in participants with moderate or severe liver function impairment compared to participants with normal liver function (also known as a healthy volunteer). Pharmacokinetics (or PK) is the study of how your body absorbs, breaks down, and removes... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/21/2025
Locations: Clinical Pharmacology of Miami, Miami, Florida +1 locations
Conditions: Healthy, Hepatic Impairment
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Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
NCT06989320
Recruiting
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will ingest fixed diets containing low amounts of oxalate for 5 days ingest a soluble form of glycolate and vitamin C collect urine,... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/16/2025
Locations: United States, Alabama University of Alabama at Birmingham, Birmingham, Alabama +1 locations
Conditions: Kidney Stones, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate, Nephrolithiasis, Nephrolithiasis, Calcium Oxalate, Oxalate Urolithiasis, Healthy, Healthy Volunteer
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MAD Study of IA-14069
NCT05533372
Recruiting
The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending oral doses of IA-14069 in healthy subjects and in patients with RA on stable dosese of MTX, with preliminary assessment of efficacy in RA patients.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/15/2025
Locations: ICON plc., Lenexa, Kansas
Conditions: Healthy, Rheumatoid Arthritis
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The Effect of Nutritional Supplementation on Actinic Purpura: A Pilot Study
NCT06840574
Recruiting
Purpura is a macule or papule of blood in the skin. It is mostly seen in mature skin that is often prone to significant bruising. Small lesions of less than 5 mm are called petechiae and larger ones, found mostly in subcutaneous tissue, are called ecchymosis. Actinic purpura occurs almost exclusively in elderly populations. This single-blind randomized clinical trial evaluates the effect of an 8-week nutritional supplement intervention in comparison with isolated vitamin C supplements on actinic... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/12/2025
Locations: Standard Process - Nutrition Innovation Center, Kannapolis, North Carolina
Conditions: Skin Health, Skin Aging of Face and Hands, Healthy, Ecchymosis
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