There are currently 241 active clinical trials seeking participants for Healthy research studies. The states with the highest number of trials for Healthy participants are California, Florida, Texas and Maryland.
Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy
NCT07122739
Recruiting
This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults. This real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention delivers feedback based on a functional connection between the prefrontal cortex and the hippocampus.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/11/2025
Locations: Princeton Neuroscience Institute, Princeton, New Jersey
Conditions: Healthy
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Relationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
NCT07009717
Recruiting
Great Toe Strength (GTS) is a potential clinical biomarker that has been associated with functional mobility and health; Additionally, GTS has been identified in the literature as one of the early symptoms of chemotherapy-induced peripheral neuropathy (CIPN). The purpose of this research study is to evaluate GTS in individuals with CIPN and healthy adults using ToeScale and see how it relates to nerve issues from chemotherapy. Additionally, we aim to assess the usability of the novel GTS assessm... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/05/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Chemotherapy-induced Peripheral Neuropathy (CIPN), Healthy
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LH-001 vs Placebo in Healthy Participants
NCT06546449
Recruiting
The purpose of this clinical trial is to evaluate the safety and tolerability of LH-001 when administered as an oral, single or multiple dose(s) at ascending dose levels in healthy participants.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/05/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Healthy
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Effects of DigiVibe on Pain in Subjects Undergoing Intramuscular Injections, Subcutaneous Injections, and Fingersticks
NCT06987201
Recruiting
This is a single-center, unblinded, prospective, cross-over study. The study population will include twenty (n=20) healthy subjects (10 men and 10 women) over the age of 18 with a self-reported fear/dislike of needles. Subjects who qualify for the study based on the study inclusion and exclusion criteria and who consent to participate in the study will undergo two (2) intramuscular (IM) injections in the deltoid muscle, two (2) subcutaneous (SC) injections in the abdomen, and two (2) fingerstick... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/04/2025
Locations: Universal Axon Clinical Research, LLC, Doral, Florida
Conditions: Healthy
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A Study of LY4088044 in Healthy Participants
NCT07090785
Recruiting
The purpose of this study is to evaluate how well LY4088044 is tolerated and what side effects may occur in healthy participants. The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to check how much LY4088044 gets into the bloodstream and how long it takes the body to eliminate it. The study will last up to approximately 92 weeks for Parts A, B, and C, excluding screening.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/01/2025
Locations: Collaborative Neuroscience Network - CNS, Los Alamitos, California +1 locations
Conditions: Healthy
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SV2 PET Imaging With [11C]APP311
NCT03995121
Recruiting
The aim of this study is to evaluate a new SV2A tracer, \[11C\]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
07/31/2025
Locations: Conneticut Mental Health Center, New Haven, Connecticut
Conditions: Schizophrenia and Other Psychotic Disorders, Cannabis Use Disorder, Healthy
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A Study of the Blood Levels of Palovarotene in Participants With Abnormal Liver Function Compared to Healthy Adult Participants After Intake of a Single Dose
NCT06908954
Recruiting
The main aim of this study is to understand how moderate and severe liver impairment (based on the Child-Pugh classification) affects the body's processing of a single dose of 10 mg maximum of palovarotene, compared to healthy participants with normal liver function. The study will also assess the safety and tolerability of the single dose of palovarotene. Participants will be enrolled in stages and divided into three groups based on their liver function: * Group 1: Healthy participants with... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/31/2025
Locations: ERG - Clinical Pharmacology of Miami, Miami, Florida +2 locations
Conditions: Hepatic Impairment, Healthy
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In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans
NCT04920539
Recruiting
In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/31/2025
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: HIV Infections, Healthy
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Multi-System Analysis of Opioid Receptor Binding
NCT05528848
Recruiting
This study will enroll up to 60 adults (including 30 females and 30 males) in three cohorts of up to 20 subjects each. In all three groups, \[11C\]carfentanil whole-body PET imaging will be used to examine the central nervous system (CNS) and broader systemic opioid binding in an initial scan session. In the two groups not receiving standard of care medication assisted treatment (MAT) for opioid use disorder (OUD) the effects on \[11C\]carfentanil binding potential of the blockade of opioid bind... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/31/2025
Locations: University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania
Conditions: Healthy, Opioid Use Disorder
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tFUS Induced Transient Scotoma for Individual Dosing
NCT06426498
Recruiting
The purposes of this research study is to: 1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measured. 2. Use this technique to measure threshold for effective tFUS in individuals. 3. Determine whether disruption of conscious visual detection, versus non-conscious visually-guided behavior have different thresholds for disruption with tFUS.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/31/2025
Locations: Medical University of South Carolina Brain Stimulation Division, Charleston, South Carolina
Conditions: Healthy
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Medical Illustration Design Characteristic Evaluation
NCT06435806
Recruiting
The goal of this study is to understand what people understand from medical illustrations, and what meaning and emotions (such as anxiety) they derive from different design elements.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Tufts Medical Center, Boston, Massachusetts +1 locations
Conditions: Healthy
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A Study to Evaluate Safety, Tolerability, and Immunogenicity of V350A and V350B in Healthy Participants (V350-001).
NCT06655324
Recruiting
Epstein Barr virus (EBV) is a virus which can cause infectious mononucleosis and is associated with certain kinds of cancer and multiple sclerosis. Researchers are looking for new ways to prevent disease related to EBV and have developed a new study vaccine (V350A and V350B). The main goal of this study is to learn about the safety and tolerability of V350A and V350B in healthy adults.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
07/30/2025
Locations: California Clinical Trials Medical Group managed by PAREXEL ( Site 0011), Glendale, California +8 locations
Conditions: Healthy
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