Illinois is currently home to 2664 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
NCT04457596
Recruiting
This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors, and delivers DM1 to kill them. Tucatinib may stop t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Saint Anthony's Health, Alton, Illinois
Conditions: Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Multifocal Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage III Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8, Prognostic Stage IIIB Breast Cancer AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8, Synchronous Bilateral Breast Carcinoma
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Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML
NCT03709758
Recruiting
This research study is studying the combination of venetoclax and chemotherapy as a possible treatment for acute myelogenous leukemia (AML). The drugs involved in this study are: * Venetoclax * Daunorubicin * Cytarabine
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
01/09/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Acute Myeloid Leukemia
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EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment
NCT06386874
Recruiting
This is a multicenter study that will be conducted at approximately 20 centers and up to 30 centers, if the sample size will be increased following interim assessment. The Q Therapeutic System (BQ 3.0) is a wearable medical device that produces and delivers non-invasive, extremely-low-intensity and low-frequency, frequency-tuned electromagnetic fields in order to stimulate neuronal networks with the aim of reducing disability and promoting neurorecovery. The Q Therapeutic System (BQ 3.0) is in... Read More
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
01/08/2025
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Ischemic Stroke
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Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future
NCT06039176
Recruiting
Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation strategy, but also for those individuals who suffer from advanced heart failure (HF) and do not qualify for cardiac transplantation. Despite the decreasing size of the newest generation devices leading to a lessened occurrence of adverse events, bleeding an... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/08/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: LVAD, Frailty, GI Bleed, Right Heart Failure, Infections, Hypertension, Arrhythmias, Stroke
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R01.Aim 2.Study 1: IsoReach
NCT06656754
Recruiting
To determine the effects of 3D isometric movement training in healthy participants and impaired participants due to a stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke
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Safety and Feasibility of an ExoNET for Supination Assistance for Stroke Survivors
NCT06655636
Recruiting
The purpose of this study is to evaluate the safety, feasibility, and efficacy of an exoskeletal network of passive, multi-joint springs for forearm supination. Also known as the forearm ExoNET, the device is a passive, robotic device that will properly assist forearm supination in the post-stroke adult population.
Gender:
ALL
Ages:
Between 40 years and 70 years
Trial Updated:
01/07/2025
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Cerebral Vascular Accident
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Intensive Patient Referral and Education Program Prior to Renal Replacement Therapy
NCT06397456
Recruiting
Intensive Patient Referral and Education Program prior to Renal Replacement Therapy (iPREP-RRT) is a 12-week intervention that identifies hospitalized African Americans with advanced chronic kidney disease (CKD) and provides them with hospital- and community-based education, navigation and self-management support. Participants will be randomized to the iPREP-RRT intervention versus enhanced usual care.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/07/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Chronic Kidney Disease, Hypertension
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Interactive Computer-adaptive Chronic Kidney Disease Education Program
NCT06364358
Recruiting
The goal of this pilot clinical trial is to evaluate a culturally tailored computerized education program in hospitalized African-American patients with advanced chronic kidney disease (CKD). The main question it aims to answer are: does computerized adaptive education (CAE) increase patients' knowledge about CKD self-care and renal replacement therapy (RRT) options compared to usual care (UC) and will CAE will be increase patients' intent to participate in CKD self-care and RRT preparation comp... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/07/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Chronic Kidney Diseases, Hypertension
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Prospective Validation Study of High Volume Urine DNA Testing in Individuals with Suspicion of Urothelial Cancer
NCT06310759
Recruiting
Urothelial cancers of the bladder and upper urinary tract account for over 200,000 deaths and 600,000 diagnoses annually worldwide. The most common presenting symptom is hematuria (blood in urine), triggering a cascade of tests, including an invasive examination of the bladder using a flexible scope (cystoscopy). Millions of cystoscopies are performed every year worldwide for patients presenting with hematuria, but only 10% result in a cancer diagnosis. The UROSCOUT-1 trial is a prospective mult... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/07/2025
Locations: Jesse Brown Department Of Veterans Affairs Medical Center, Chicago, Illinois
Conditions: Urothelial Carcinoma
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Improvement of Hyperglycemia/Diabetes in Patients to Improve Safety
NCT06096311
Recruiting
The goal of this project is to bring together staff and clinicians from Northwestern University/Northwestern Medical Group/Northwestern Memorial Hospital as well as patients and caregivers to assess and redesign the identification and management of hyperglycemia and diabetes during and in transitions of care. There will be 3 different groups for the study: a group of providers \[Group 1\], a group of patients/caregivers and laypersons \[Group 2\], and a stakeholder group \[Group 3\]. Participant... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Diabetes Mellitus, Type 2
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Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care
NCT05483283
Recruiting
The investigator and study staff will identify, recruit and randomize Latina participants with elevated genetic and Social Determinants of Heath (SDH) risks. Within 1 week of enrollment, all Latina Aim 1 participants in both study arms will engage in three 30-minute, individual, phone-based sessions with the study team across 3 consecutive weeks
Gender:
FEMALE
Ages:
30 years and above
Trial Updated:
01/07/2025
Locations: University of Illinois, Chicago, Illinois
Conditions: Breast Cancer
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Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities
NCT05361941
Recruiting
This is a pivotal, prospective, multi-center, randomized, concurrent control, patient and assessor-blinded study with two arms: a treatment arm (where subjects will be treated with the EP Granules with Tobramycin investigational device in the 1st stage of a staged revision for periprosthetic joint infection (PJIs), and a control arm (where subjects are treated with the standard-of-care revision for infected PJIs).
Gender:
ALL
Ages:
22 years and above
Trial Updated:
01/07/2025
Locations: Endeavor Health Skokie Hospital, Skokie, Illinois
Conditions: Periprosthetic Joint Infections
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