Illinois is currently home to 2679 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Motor rECovery witH eArly imagiNg In STroke
Recruiting
This study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnormal flexion synergy, a primary movement impairment due to stroke. The study will longitudinally evaluate motor tract morphology and motor impairment/function in an attempt to develop early neuroimaging-based predictors of the development of flexion synergy and its impact on reaching and hand recover... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
03/11/2024
Locations: Department of Physical Therapy and Human Movement Sciences, Chicago, Illinois
Conditions: Stroke
Interpersonal Relationships Intervention and Cardiovascular Health
Recruiting
The purpose of this study is to determine whether random assignment to a mentor-mentee relationship is associated with beneficial cardiovascular health effects in both mentors and mentees.
Gender:
All
Ages:
Between 10 years and 25 years
Trial Updated:
03/11/2024
Locations: Northwestern, Evanston, Illinois
Conditions: Cardiovascular Health
LOWER: Lomitapide Observational Worldwide Evaluation Registry
Recruiting
This global product exposure registry is a multicentre, long-term, prospective, observational cohort study (exposure registry), designed to evaluate the long term safety and effectiveness of lomitapide.
Gender:
All
Ages:
All
Trial Updated:
03/11/2024
Locations: Comprehensive Cardiovascular Care, Gurnee, Illinois
Conditions: Homozygous Familial Hypercholesterolemia
Defining the Skin and Blood Biomarkers of Pediatric Atopic Dermatitis
Recruiting
Atopic dermatitis (AD), also known as eczema, is the most common inflammatory skin disorder of children, affecting 10-20% of children and 1-2% of adults. This skin disorder can be associated with unbearable itchiness and an increased susceptibility to skin infections. The cause of AD is currently poorly understood; therefore, there are no targeted treatment options at present. There have been recent studies in adults with AD that explain the cause and give us new routes to investigate treatment... Read More
Gender:
All
Ages:
Between 0 months and 17 years
Trial Updated:
03/11/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Atopic Dermatitis, Eczema
Combining Topical Imiquimod With Local Radiotherapy for Treatment of Mycosis Fungoides
Recruiting
Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (MF) and presents as cutaneous patches, plaques, and tumors. Radiation therapy (RT) is a frequently pursued management option for CTCL, especially in patients with more advanced skin disease. Imiquimod stimulates a Th1 lymphocyte response with increased IL-2 and IFN-α, but also induces IFN-α, TNF-α, IL-1α, IL-6, and IL-8, thereby bridging both innate and adaptive immunity. Dosing of both radiotherapy (RT) and imiquimo... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
03/08/2024
Locations: Northwestern University Department of Dermatology, Chicago, Illinois
Conditions: Mycosis Fungoides
Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study
Recruiting
This phase II trial tests the effectiveness and safety of artificial intelligence (AI) to determine dose recommendation during stereotactic body radiation therapy (SBRT) planning in patients with primary lung cancer or tumors that has spread from another primary site to the lung (metastatic). SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Lung Carcinoma, Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Lung, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors
Recruiting
Multicenter, open-label, dose-escalation, safety, tolerability, PK and pharmacodynamic study with a dose expansion at the RP2D to evaluate safety and potential antitumor activity of Q901 as a monotherapy and in combination with pembrolizumab
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Advanced Cancer, Metastatic Cancer
A Phase II Trial of Poly-ICLC for Low-Grade Gliomas
Recruiting
This is a phase II, prospective, longitudinal, multi-center trial of poly-ICLC (Hiltonol ®) treatment for progressive low-grade gliomas in pediatric patients with NF1. The primary objective is to evaluate the efficacy of poly-ICLC in pediatric NF1 patients with progressive low-grade glioma (LGG) as measured by objective tumor response rate (CR+PR) within the first 48 weeks (12 cycles) of therapy. There will also be secondary and exploratory objectives listed in the detailed description below.
Gender:
All
Ages:
22 years and below
Trial Updated:
03/08/2024
Locations: Children's Lurie Hospital, Chicago, Illinois
Conditions: NF1, Low-grade Glioma
Prospective SPINE Registry
Recruiting
This study is a prospective, multi-center, open label registry designed to collect real-world data on performance and safety data on RTI's spine products.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Suburban Orthopaedics, Bartlett, Illinois
Conditions: Sacroiliac; Fusion, Sacroiliac, Joint Diseases, Musculoskeletal Diseases, Spinal Disease, Spinal Stenosis, Spinal Instability, Fusion of Joint, Fusion of Spine, Spinal Fusion, Spine
Characterization of the Microbiome in Cutaneous T Cell Lymphoma
Recruiting
Investigators plan to perform a pilot study that aims to characterize the microbiome of human cutaneous T cell lymphoma patients and compare this to the microbiome of age and sex matched controls.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
03/08/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Cutaneous T Cell Lymphoma
StuDy AimED at Increasing AlCohol AbsTinEnce
Recruiting
The goal of this clinical trial is to test the feasibility & acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs. CM alone, to improve treatment efficacy and inform about neural mechanisms of treatment effects in young adults with Alcohol Use Disorder (AUD). The aims are as follows: K99 Aim: Test feasibility & acceptability of a developed CM-PST, by meeting these benchmarks: 2a Feasibility: enroll 20 participants in the new CM-PST in a... Read More
Gender:
All
Ages:
Between 18 years and 24 years
Trial Updated:
03/07/2024
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Alcohol Use Disorder
Dietary Supplementation on Gastrointestinal Barrier Function
Recruiting
The purpose of the current study is to examine the effects of a dietary supplement containing plant derived phenolics at two different dose levels on parameters of gastrointestinal (GI) health in otherwise generally healthy adults with risk factors (high BMI and waist circumference) for increased GI permeability. The primary hypothesis is that supplementation with plant derived phenolics will improve gut health compared to placebo.
Gender:
All
Ages:
Between 30 years and 69 years
Trial Updated:
03/06/2024
Locations: Biofortis, Addison, Illinois
Conditions: Intestinal Permeability