Illinois is currently home to 2679 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)
Recruiting
The goal of this clinical trial is to test the Break Waveâ„¢ system in patients with upper urinary tract stones. The main question it aims to answer is whether the device is safe and effective in fragmenting (breaking) stones. Participants will a) undergo the Break Waveâ„¢ procedure, b) have a telehealth visit at 2 weeks, and c) return for an imaging study at approximately 10 weeks post-procedure.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: Northwestern Medicine, Chicago, Illinois
Conditions: Kidney Stone, Urolithiasis, Nephrolithiasis, Renal Calculi, Kidney Calculi, Nephrolith, Urinary Calculi
Safety and Tolerability of KH631 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration
Recruiting
VAN-2201 is Phase I clinical trial to assess the safety and tolerability of KH631 in subjects with neovascular AMD. KH631 is gene therapy designed to deliver a protein which targets and blocks VEGF via an adeno-associated viral vector. The standard of care for patients with neovascular AMD are anti-VEGF treaments, which have demonstrated improvement in vision and reduction in fluid. A one time placement of a product which inhibits VEGF has the potential to reduce the patient burden of regular in... Read More
Gender:
All
Ages:
Between 50 years and 85 years
Trial Updated:
02/23/2024
Locations: Kanghong Investigative Site, Lemont, Illinois
Conditions: Age-Related Macular Degeneration
Exactech Shoulder Post Market Clinical Follow-up Study
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
All
Ages:
21 years and above
Trial Updated:
02/23/2024
Locations: OrthoIllinois, Rockford, Illinois
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
Recruiting
This is a single-center, prospective, randomized, single-blind, comparator therapy, parallel group study for symptomatic patients diagnosed with knee osteoarthritis. The aim is to demonstrate superior efficacy of platelet-rich plasma (PRP) as compared to hyaluronic acid (HA) in treating knee osteoarthritis. This aim will be objectively measured by endpoint consisting of changes in cartilage thickness from baseline in the MRI. The Knee Injury and Osteoarthritis Outcome Score (KOOS) Questionnaire... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/23/2024
Locations: NorthShore University HealthSystems, Skokie, Illinois
Conditions: Knee Osteoarthritis
Deep Functional Phenotyping of the ALA Lung Health Cohort
Recruiting
The goal of this observational study is to learn about lung structure and function in a group of 1000 healthy people aged 25 to 35. The main questions it aims to answer are whether people's bodies, environment, and general lung health are associated with: the structure of the participants lungs' airways, the structure of blood vessels in the participants lungs and heart, and the participants lungs' ability to exchange gases. Participants will take four different lung function tests to measure... Read More
Gender:
All
Ages:
Between 25 years and 35 years
Trial Updated:
02/21/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Lung Diseases
Cardiogenic Shock Working Group Registry
Recruiting
The Cardiogenic Shock Working Group is a multicenter registry where we collect de-identified clinical variables from the medical records and follow-up phone calls of shock patients from multiple institutions and centralize this data to a single registry for analysis of clinical outcomes.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/21/2024
Locations: Northwestern Medicine, Chicago, Illinois
Conditions: Cardiogenic Shock
rTMS Target Identification for Functional Disability in AUD+mTBI
Recruiting
The objectives of this VA Merit application are to identify a neural target unique to Veterans with co-occurring alcohol use disorder and mild traumatic brain injury (AUD+mTBI) and to test the efficacy of this target as a stimulation site for repetitive transcranial magnetic stimulation (rTMS) treatment to maximize functional recovery. rTMS will soon be a treatment option at 30 VAs nationwide and preliminary studies show promise for AUD and mTBI treatment. A better understanding of how AUD+mTBI... Read More
Gender:
All
Ages:
Between 22 years and 65 years
Trial Updated:
02/21/2024
Locations: Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois
Conditions: Alcohol Use Disorder, Mild Traumatic Brain Injury
Nasal Antisepsis for C. Auris Prevention
Recruiting
This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/20/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Candida Auris Infection, Colonization, Asymptomatic
The Effect of the Inclusion of Soybean Flour on Glycemic Responses
Recruiting
Foods that release glucose rapidly, leading to spikes in blood sugar and insulin (known as high glycemic index foods), generate lower satiety responses than foods with low glycemic index. High glycemic index foods are also linked to an increased risk of developing diabetes. The partial replacement of carbohydrates in rich staple foods with soy flour has the potential to reduce glycemic response and improve satiety. In many regions of Latin America, as well as in the Middle East and North Africa... Read More
Gender:
All
Ages:
Between 21 years and 45 years
Trial Updated:
02/20/2024
Locations: University of Illinois at Urbana Champaign, Champaign, Illinois
Conditions: Overweight and Obesity
Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration
Recruiting
This is a Phase 1, multicenter, open-label, single- and multi-dose, dose-escalating study of OLX10212 in patients with neovascular age-related macular degeneration (AMD). This study is composed of 2 parts: Part A and Part B. Part A is a single ascending dose study, and Part B is a multiple ascending dose study. The primary objective is to evaluate the safety and tolerability of single and multiple intravitreal injection(s) of OLX10212 in patients with neovascular AMD. The exploratory objectives... Read More
Gender:
All
Ages:
50 years and above
Trial Updated:
02/20/2024
Locations: University Retina, Oak Forest, Illinois
Conditions: Neovascular Age-related Macular Degeneration
Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal
Recruiting
Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mecha... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/20/2024
Locations: Physical Therapy, Chicago, Illinois
Conditions: Stroke
A Randomized Controlled Trial of Geriatric Emergency Department Innovations
Recruiting
This study evaluates the Geriatric Emergency Department Innovations (GEDI) program at Northwestern Memorial Hospital to care for older adults in the emergency department. Half of the patients will be cared for by a standard ED team plus the GEDI team, while half of the patients will receive usual ED care.
Gender:
All
Ages:
65 years and above
Trial Updated:
02/20/2024
Locations: Northwestern University Department of Emergency Medicine, Chicago, Illinois
Conditions: Frailty