Illinois is currently home to 2661 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564
Recruiting
This study is a postmarketing requirement jointly carried out by four NDA holders (Bayer AG, Bracco, GE Healthcare and Guerbet) and the CRO IQVIA. The study aims to create detailed images of the organs and tissue of the human body during x-ray, CT-scan or MRI investigations, doctors are using contrast media (a kind of dye) which can be given to patients by injection into a blood vessel or by mouth. In this study researchers want to find out whether so called gadolinium-based contrast agents (G... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
01/08/2023
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Motor Function, Cognitive Function, Contrast Media
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I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy
NCT05537922
Recruiting
I3LUNG is an international project aiming to develop a medical device to predict immunotherapy efficacy for NSCLC patients using the integration of multisource data (real word and multi-omics data). This objective will be reached through a retrospective - setting up a transnational platform of available data from 2000 patients - and a prospective - multi-omics prospective data collection in 200 NSCLS patients - study phase. The retrospective cohort will be used to perform a preliminary knowledg... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2023
Locations: University of Chicago, Chicago, Illinois
Conditions: Non Small Cell Lung Cancer, Lung Cancer Metastatic, Lung Cancer, Nonsmall Cell, Lung Adenocarcinoma
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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
NCT01696721
Recruiting
In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it is associated with less severe long term side effects. However, there is limited published data demonstrating these results. The goal of the Proton and Photon Consortium Registry (PPCR) is to enroll children treated with radiation in order to describe the population that... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
01/05/2023
Locations: Northwestern Medicine Chicago Proton Center, Warrenville, Illinois
Conditions: Pediatric Patients Treated With Radiation Therapy
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Estimated VO2Max Validation
NCT05678530
Recruiting
In this study, the hypothesis being explored is that VO2Max and other CPET parameters can be accurately estimated from biosignals (namely, motion from accelerometers and cardiopulmonary variables from EKG) collected during activities of daily living using wearable biosensors worn by study participants. This study will aim to collect development and validation data for a machine learning algorithm and to evaluate the performance of the algorithm. A total of 300 participants will be enrolled inclu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/04/2023
Locations: physIQ, Chicago, Illinois
Conditions: Heart Failure, Healthy
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Antidepressant Effects of Nitrous Oxide
NCT05357040
Recruiting
To evaluate the acute and sustained antidepressant effects of nitrous oxide in people with major depressive disorder; and further evaluate these effects by identifying the optimal dose and regimen to guide current practice, and to plan a future large pragmatic trial.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/21/2022
Locations: University of Chicago Medicine, Chicago, Illinois
Conditions: Major Depressive Disorder, Treatment Resistant Depression
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Studying Language With Brain Stimulation in Aphasia
NCT05660304
Recruiting
The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/20/2022
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Aphasia
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Comparing Intubation Rates in the Delivery Room by Interface
NCT05609773
Recruiting
Although the majority of premature neonates < 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined. Preferably this support would be provided by non-invasive means to prevent the development of bronchopulmonary dysplasia. Resuscitation with a face mask, single nasal tube, nasal prongs, and/or LMA are all approved methods of resuscitation per NRP as of 2010. Face masks have been associated with more dead space, air lea... Read More
Gender:
All
Ages:
Between 0 weeks and 30 weeks
Trial Updated:
12/15/2022
Locations: University of Illinois College of Medicince, Peoria, Illinois
Conditions: Ventilator Lung; Newborn
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Comparison of Diuretic Effect With Furosemide Alone Versus the Combination of Furosemide and Albumin in Cirrhotic Patients
NCT04216784
Recruiting
A common complication of the progression of cirrhosis is fluid retention (ascites, edema, or pleural effusion). Loop diuretics are the treatment of choice for fluid retention in cirrhotic patients; however, many of these patients demonstrate diuretic resistance, requiring higher doses of the diuretics to achieve adequate diuresis. The cause of this diuretic resistance is hypothesized to be secondary to hypoalbuminemia which has led some providers to give human albumin in combination with loop di... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/13/2022
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Cirrhosis, Liver, Volume Overload, Fluid Overload
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A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT02817633
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy
Gender:
All
Ages:
18 years and above
Trial Updated:
12/09/2022
Locations: GSK Investigational Site, Arlington Heights, Illinois
Conditions: Neoplasms
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Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System
NCT03831386
Recruiting
Malignant pleural effusion remains a debilitating complication of end stage cancer, which can be greatly improved by the introduction of the indwelling tunneled pleural catheter (IPC). However, there is no standard of care regarding drainage and limited data on the utility of different drainage techniques. In addition, many patients develop discomfort and chest pain during drainage. The investigators propose to evaluate gravity drainage and suction drainage on quality of life measures and outcom... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/06/2022
Locations: Northwest Community Healthcare, Arlington Heights, Illinois
Conditions: Pleural Effusion
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An Avatar-based Mobile Phone Intervention to Promote Health in African American MSM
NCT04217174
Recruiting
The investigators propose to determine the efficacy of "My Personal Health Guide," a theory-based innovative talking relational human Avatar mobile phone application to engage HIV-positive AAMSM in adherence and retention in care. Providing an empathetic talking Avatar source of HIV-related information, motivation, and behavioral skills that is as private and convenient as their own mobile phone might produce a high impact by overcoming barriers to HIV adherence and retention in care such as sti... Read More
Gender:
Male
Ages:
Between 18 years and 34 years
Trial Updated:
12/01/2022
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Medication Adherence, Retention in Care
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Volumetric Specimen Imager Device for the Intraoperative Imaging of Patients With Breast Carcinoma and Breast Ductal Carcinoma In Situ, The VIVID Study
NCT05545150
Recruiting
This clinical trial assesses if the use of a three-dimensional imaging device called the Clarix Imaging Volumetric Specimen Imager (VSI) can help guide and assist surgeons in identifying and removing all positive margins while in the operating room (intraoperative imaging) for patients with breast cancer and breast ductal carcinoma in situ. Breast conservation surgery or lumpectomy is a standard of care (routine) procedure that removes the tumor and a rim of surrounding normal tissue (margins) w... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/30/2022
Locations: Northwestern University, Chicago, Illinois
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8, Bilateral Breast Carcinoma, Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma, Multicentric Breast Carcinoma, Prognostic Stage 0 Breast Cancer AJCC v8
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