Illinois is currently home to 2637 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration
NCT05643118
Recruiting
This is a Phase 1, multicenter, open-label, single- and multi-dose, dose-escalating study of OLX10212 in patients with neovascular age-related macular degeneration (AMD). This study is composed of 2 parts: Part A and Part B. Part A is a single ascending dose study, and Part B is a multiple ascending dose study. The primary objective is to evaluate the safety and tolerability of single and multiple intravitreal injection(s) of OLX10212 in patients with neovascular AMD. The exploratory objectives... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/20/2024
Locations: University Retina, Oak Forest, Illinois
Conditions: Neovascular Age-related Macular Degeneration
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Cortical Priming to Optimize Gait Rehabilitation in Stroke: a Renewal
NCT04477330
Recruiting
Achieving functional ambulation post stroke continues to be a challenge for stroke survivors, clinicians, and researchers. In the effort to enhance outcomes of motor training, cortical priming using brain stimulation has emerged as a promising adjuvant to conventional rehabilitation. This project focuses on the development of a long term gait rehabilitation protocol using brain stimulation to improve walking outcomes in people with stroke. The project will also aim to understand the neural mecha... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/20/2024
Locations: Physical Therapy, Chicago, Illinois
Conditions: Stroke
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Prophylactic Minimally Invasive Surfactant Evaluation
NCT06007547
Recruiting
The purpose of this study is to explore the question: Does prophylactic administration of exogenous surfactant in the delivery room, using a minimally-invasive technique, improve outcome in preterm infants 22-29 weeks' gestation compared to rescue treatment using the same technique?
Gender:
ALL
Ages:
15 minutes and below
Trial Updated:
02/19/2024
Locations: Northshore University Healthsystem, Evanston, Illinois
Conditions: Respiratory Distress Syndrome, Newborn, Premature Birth
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Reducing Postoperative Opioids in Patients Undergoing Laparoscopic Hiatal Hernia
NCT05953428
Recruiting
This is a prospective randomized, double-blinded, controlled trial that will enroll 75 subjects undergoing laparoscopic hiatal hernia repair surgery. Participants who meet eligibility criteria will be randomized in a 1:1 ratio to receive either the opioid sparring anesthesia protocol (OSA) or the opioid based anesthesia protocol (OBA). The purpose of this study is to investigate if an opioid sparring protocol for laparoscopic hiatal hernia repair will reduce opioid consumption during discharge.... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
02/19/2024
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Hiatal Hernia
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VivAer: A Correlation Between Symptom Scores and Objective Findings
NCT05573919
Recruiting
This is a prospective, single-center study. This study seeks to determine the objective improvement in nasal airflow in patients after undergoing the VivAer procedure, which involves the use of a stylus to deliver controlled and targeted low energy radiofrequency heating (heating by applying high-frequency radio waves) to the nasal sidewall to gently reshape the tissues. Patients who experience refractory, or medically unexplained, nasal obstruction often have symptoms that are not alleviated or... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2024
Locations: Swedish Covenant Hospital, Chicago, Illinois
Conditions: Nasal Obstruction, Medically Unexplained Symptoms, Airway Obstruction, Airway Remodeling
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A Study to Investigate Leramistat in Patients With IPF
NCT05951296
Recruiting
To compare the effect of daily oral dosing of leramistat over 12 weeks with placebo in participants aged 40 years or older with idiopathic pulmonary fibrosis (IPF).
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/16/2024
Locations: GenHarp Clinical Solutions, Chicago, Illinois
Conditions: Idiopathic Pulmonary Fibrosis
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Reducing Opioid Mortality in Illinois
NCT04925427
Recruiting
Reducing Opioid Mortality in Illinois (ROMI) is 5-year research study led by the University of Chicago in partnership with the University of Illinois at Chicago's (UIC) Community Outreach Intervention Projects (COIP), the Illinois Criminal Justice Information Authority (ICJIA) and the American Institutes for Research (AIR). ROMI aims to understand and test strategies for linking individuals with a history of opioid use disorder who are released from Illinois jails and prisons to substance use tr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/16/2024
Locations: Cook County Department of Corrections, Chicago, Illinois
Conditions: Opioid Use, Opioid-use Disorder
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Mechanical Coring to Achieve Directional Skin Tightening
NCT04910945
Recruiting
The objective of this clinical study is to evaluate the safety and efficacy of mechanical coring for directional skin tightening. This study is a prospective, up to 3 center, multiple skin treatment area study of the safety and efficacy of mechanical coring with directional closure to achieve directional skin tightening.
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
02/13/2024
Locations: DeNova Research, Chicago, Illinois
Conditions: Skin Tightening, Healthy Volunteers
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The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
NCT04329728
Recruiting
This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with lymphoid malignancies.
Gender:
ALL
Ages:
Between 12 years and 95 years
Trial Updated:
02/13/2024
Locations: University of Illinois at Chicago Cancer Center, Chicago, Illinois
Conditions: Lymphoid Malignancies
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Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF
NCT05639556
Recruiting
The goal of the study is to examine multiple markers of anthropometrics, body composition, sarcopenia and frailty and compare them to dual energy X-ray absorptiometry (DXA) output, which is considered the current clinical gold-standard tool to measure body composition. The result of this study will provide detailed data regarding the nutrition and body composition within this Cystic Fibrosis population and also provide a baseline evaluation for use of these biomarkers in the future studies inclu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: Northwestern University, Chicago, Illinois
Conditions: Cystic Fibrosis
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Decitabine and Selinexor in Combination to Reverse Drug Resistance With Standard Chemotherapy in Ovarian Cancer
NCT05983276
Recruiting
The goal of this clinical trial is to learn about the side effects and effectiveness of this novel four-drug combination of chemotherapy (decitabine, selinexor, carboplatin and paclitaxel) on patients with relapsed ovarian, fallopian or primary peritoneal carcinoma. Recently the investigators have found that the combination of decitabine and selinexor, two Food and Drug Administration (FDA) approved chemotherapy agents, may prevent or reverse the development of drug resistance and further the r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2024
Locations: Loyola University Medical Center, Maywood, Illinois
Conditions: Ovarian Cancer
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Sleep Length and Euploid Embryo Transfer Prospective Study
NCT06139757
Recruiting
Sleep is a critical component of daily life that significantly influences health and well-being. Despite the integral role sleep plays in life, its effect on women's reproductive health, and its subsequent impact on fertility, is largely understudied. The purpose of the SLEEP Study is to investigate the link between sleep and fertility. Participants will use a wireless wearable device mounted on the finger to measure sleep in the weeks preceding and following an embryo transfer during treatment... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
02/05/2024
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Infertility, Female
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