Illinois is currently home to 2622 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma
Recruiting
The purpose of this research study is to determine the effects bevacizumab (the study drug) combined with Optune (the study device) tumor treatment field therapy has on meningiomas. Bevacizumab is considered investigational because the US Food and Drug Administration (FDA) has not approved its use for the treatment of meningiomas. The study drug is a medication that blocks the growth of new blood vessels. It is thought that the study drug may interfere with the growth of new blood vessels and th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/25/2022
Locations: Northwestern University, Chicago, Illinois
Conditions: Anaplastic (Malignant) Meningioma, Atypical Meningioma, Grade II Meningioma, Grade III Meningioma, Recurrent Meningioma, Supratentorial Meningioma
Utilization of a Videoscope in Periodontal Regeneration
Recruiting
Clinical and preclinical studies confirm that regeneration of supporting tissues of teeth lost due to periodontal disease can be achieved using the principles of minimally invasive surgery (MIS). Although this therapeutic approach is well established in clinical settings and can rescue teeth with poor or questionable prognosis, MIS approaches often suffer from lack of predictability due to poor intraoral visibility of the bony lesion and inability to confirm thorough removal of etiological facto... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/24/2022
Locations: University of Illinois, Chicago, College of Dentistry, Periodontics, Chicago, Illinois
Conditions: Chronic Periodontitis
Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing
Recruiting
This will be a randomized controlled clinical trial in patients who have undergone primary unilateral total knee arthroplasty at Brigham and Women's Faulkner Hospital, Brigham and Women's Hospital and University of Chicago Medical Center. Study subjects will receive either a shared decision aid (SDA) about pain management or standard of care at the time of discharge. The impact of the SDA on the number of leftover opioid pills on postoperative day 30 and average NRS pain score on postoperative d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/23/2022
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Knee Arthroplasty, Total, Analgesia, Opioid Use, Unspecified
Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy
Recruiting
This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day). The primary efficacy assessment will be based on the Unified Dyskinesia Rating Scale (UDysRS). Patients who complete the 12-week blinded treatment period may have the option to roll into an open-label safety extension study for an additional 12-month treatment period.
Gender:
All
Ages:
Between 30 years and 85 years
Trial Updated:
05/18/2022
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Parkinson Disease, Dyskinesia, Drug-Induced, Dyskinesias
Patient Navigators for Children's Community Mental Health Services in High Poverty Urban Communities
Recruiting
The purpose is to study a model of mental health navigation for African American and Latinx children (5-12 years) in high poverty urban communities focused on reducing key parental attitudinal barriers to care. Reducing persistent racial and ethnic disparities in children's mental health is a national priority and patient navigation is a highly promising approach that is rarely used in children's mental health services. The study will examine the effectiveness of paraprofessional (PP) navigators... Read More
Gender:
All
Ages:
Between 5 years and 12 years
Trial Updated:
05/17/2022
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Community Mental Health Services
Development of a Clinically-relevant Test for Assessment of Cerebral Vascular Function
Recruiting
The goal of this study is to develop a test of cerebral vessel function by inducing a reactive hyperemia that will elicit a rapid and profound increase in cerebral vessel shear stress. The results of this project may lead to development of a test with prognostic/predictive utility for individual risk assessment of a future cerebrovascular event/disease. This information will be of vital importance to the medical community in regards to cerebrovascular health in aging individuals, and testing of... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/17/2022
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Cerebrovascular Disorders, Cerebrovascular Disease
Diabetic Fibular Nail Study
Recruiting
Our null hypothesis is that fibular intramedullary fixation (IMFN) does not impact complication rates when compared to standard of care treatment with open reduction and internal fixation (ORIF). There are no current or past RCTs comparing these fixation techniques to one another in diabetic patients. There is good data supporting both the use of intramedullary fixation for fibular fractures alone, and in high-risk patient populations (elderly, and diabetics). However, the effectiveness of these... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/16/2022
Locations: University of Chicago, Chicago, Illinois
Conditions: Ankle Fractures
Acute Intermittent Hypoxia in Traumatic Brain Injury
Recruiting
This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors. First, we aim to establish whether brief reductions in inhaled oxygen concentration can be safely tolerated in TBI survivors. Second, we aim to establish whether there are any effects of AIH on memory, cognition, and motor control. Participants will be monitored closely for any adverse events during these experiments. Data will be an... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/10/2022
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Brain Injuries, Traumatic
KRT-232 in Combination With TL-895 for the Treatment of R/R MF and KRT-232 for the Treatment of JAKi Intolerant MF
Recruiting
This study evaluates KRT-232 in Combination With TL-895 for the Treatment of Relapsed or Refractory Myelofibrosis and KRT-232 for the Treatment of JAK Inhibitor Intolerant Myelofibrosis.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/05/2022
Locations: Carle Cancer Center, Urbana, Illinois
Conditions: Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis, Primary Myelofibrosis
Oscillation and Lung Expansion Therapy in Patients With COVID-19
Recruiting
A Pilot Study of the Use of Oscillation and Lung Expansion (OLE) Therapy in Patients Hospitalized with COVID-19
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2022
Locations: Northwestern University, Evanston, Illinois
Conditions: COVID-19, Oscillation and Lung Expansion
A Study to Evaluate the Efficacy and Safety of Rosnilimab (ANB030) in Treatment of Subjects With Moderate-to-Severe Alopecia Areata
Recruiting
Efficacy and safety of rosnilimab (ANB030) in subjects with moderate-to-severe Alopecia Areata
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/03/2022
Locations: Site 10-115, Chicago, Illinois
Conditions: Alopecia Areata
International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors
Recruiting
Partial nephrectomy (PN) is the standard treatment for localized renal masses and should be preferred in clinical T1 (<7 cm tumor diameter) renal tumors over radical nephrectomy (RN) whenever technically feasible. Nonetheless, indications, approaches, techniques for PN, and correct reporting of outcomes, are still a matter of great debate within the urology community. Concurrently, case-report series suggested that alternative strategies for the treatment of localized renal tumors (ablation tech... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/02/2022
Locations: Loyola University Medical Center, Edward Hines VA Hospital, Chicago, Illinois
Conditions: Kidney Cancer