Illinois is currently home to 2681 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Nitrous Oxide for the Treatment of Major Depressive Disorder
NCT03869736
Recruiting
The investigators are conducting a randomized controlled trial to evaluate the antidepressant effects of nitrous oxide in people with Major Depressive Disorder (MDD). MDD is a global medical condition that causes significant health and economic burden. Recent studies have shown that a single dose of ketamine, an NMDA-antagonist, has fast and long lasting anti-depressant effect. Nitrous oxide, another NMDA-antagonist, is widely used for anesthesia and analgesia, safer to administer and has fewer... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/09/2023
Locations: University of Chicago Medicine, Chicago, Illinois
Conditions: Depression, Major Depressive Disorder
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I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy
NCT05537922
Recruiting
I3LUNG is an international project aiming to develop a medical device to predict immunotherapy efficacy for NSCLC patients using the integration of multisource data (real word and multi-omics data). This objective will be reached through a retrospective - setting up a transnational platform of available data from 2000 patients - and a prospective - multi-omics prospective data collection in 200 NSCLS patients - study phase. The retrospective cohort will be used to perform a preliminary knowledg... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2023
Locations: University of Chicago, Chicago, Illinois
Conditions: Non Small Cell Lung Cancer, Lung Cancer Metastatic, Lung Cancer, Nonsmall Cell, Lung Adenocarcinoma
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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
NCT01696721
Recruiting
In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it is associated with less severe long term side effects. However, there is limited published data demonstrating these results. The goal of the Proton and Photon Consortium Registry (PPCR) is to enroll children treated with radiation in order to describe the population that... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
01/05/2023
Locations: Northwestern Medicine Chicago Proton Center, Warrenville, Illinois
Conditions: Pediatric Patients Treated With Radiation Therapy
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Studying Language With Brain Stimulation in Aphasia
NCT05660304
Recruiting
The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/20/2022
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Aphasia
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Comparing Intubation Rates in the Delivery Room by Interface
NCT05609773
Recruiting
Although the majority of premature neonates < 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined. Preferably this support would be provided by non-invasive means to prevent the development of bronchopulmonary dysplasia. Resuscitation with a face mask, single nasal tube, nasal prongs, and/or LMA are all approved methods of resuscitation per NRP as of 2010. Face masks have been associated with more dead space, air lea... Read More
Gender:
All
Ages:
Between 0 weeks and 30 weeks
Trial Updated:
12/15/2022
Locations: University of Illinois College of Medicince, Peoria, Illinois
Conditions: Ventilator Lung; Newborn
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Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System
NCT03831386
Recruiting
Malignant pleural effusion remains a debilitating complication of end stage cancer, which can be greatly improved by the introduction of the indwelling tunneled pleural catheter (IPC). However, there is no standard of care regarding drainage and limited data on the utility of different drainage techniques. In addition, many patients develop discomfort and chest pain during drainage. The investigators propose to evaluate gravity drainage and suction drainage on quality of life measures and outcom... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/06/2022
Locations: Northwest Community Healthcare, Arlington Heights, Illinois
Conditions: Pleural Effusion
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An Avatar-based Mobile Phone Intervention to Promote Health in African American MSM
NCT04217174
Recruiting
The investigators propose to determine the efficacy of "My Personal Health Guide," a theory-based innovative talking relational human Avatar mobile phone application to engage HIV-positive AAMSM in adherence and retention in care. Providing an empathetic talking Avatar source of HIV-related information, motivation, and behavioral skills that is as private and convenient as their own mobile phone might produce a high impact by overcoming barriers to HIV adherence and retention in care such as sti... Read More
Gender:
Male
Ages:
Between 18 years and 34 years
Trial Updated:
12/01/2022
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Medication Adherence, Retention in Care
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Volumetric Specimen Imager Device for the Intraoperative Imaging of Patients With Breast Carcinoma and Breast Ductal Carcinoma In Situ, The VIVID Study
NCT05545150
Recruiting
This clinical trial assesses if the use of a three-dimensional imaging device called the Clarix Imaging Volumetric Specimen Imager (VSI) can help guide and assist surgeons in identifying and removing all positive margins while in the operating room (intraoperative imaging) for patients with breast cancer and breast ductal carcinoma in situ. Breast conservation surgery or lumpectomy is a standard of care (routine) procedure that removes the tumor and a rim of surrounding normal tissue (margins) w... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/30/2022
Locations: Northwestern University, Chicago, Illinois
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8, Bilateral Breast Carcinoma, Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma, Multicentric Breast Carcinoma, Prognostic Stage 0 Breast Cancer AJCC v8
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Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options
NCT03583164
Recruiting
A study to evaluate F901318 (study drug) for the treatment of invasive fungal infections in patients lacking suitable alternative treatment options.
Gender:
All
Ages:
16 years and above
Trial Updated:
11/30/2022
Locations: University of Chicago, Chicago, Illinois
Conditions: Invasive Fungal Infections
Register for Updates
A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer
NCT03899636
Recruiting
Subjects will be offered the opportunity to participate in a randomized, controlled, 2-arm, unblinded multicenter trial (RCT). There will be 2 study arms: the control arm receiving chemotherapy with the modified FOLFIRINOX regimen alone; and the irreversible electroporation (IRE) arm, receiving chemotherapy with the modified FOLFIRINOX regimen followed by IRE with the NanoKnife System using either an open or a percutaneous approach. All subjects will be treated with the modified FOLFIRINOX regim... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/23/2022
Locations: Northwest Community Healthcare, Arlington Heights, Illinois
Conditions: Stage III Pancreatic Cancer
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MEASuRE: Metreleptin Effectiveness And Safety Registry
NCT02325674
Recruiting
The study is a post-authorization, prospective, voluntary registry of patients treated with commercial metreleptin including, but not limited to, patients in the US and EEA.
Gender:
All
Ages:
All
Trial Updated:
11/23/2022
Locations: Northwestern University Children's Memorial Hospital, Chicago, Illinois
Conditions: Generalised Lipodystrophy, Partial Lipodystrophy
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Two Year Developmental Follow-up for PREMOD2 Trial (Premature Infants Receiving Milking or Delayed Cord Clamping)
NCT03476980
Recruiting
An extension of the PREMOD2 trial, the PREMOD2 Follow-Up trial will evaluate the neurodevelopmental outcomes at 22-26 months corrected age of preterm children who received UCM or DCC. This prospective multi-national randomized controlled trial (RCT) is a two-arm parallel non-inferiority design of two alternative approaches of treatment.
Gender:
All
Ages:
Between 22 months and 42 months
Trial Updated:
11/22/2022
Locations: John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois
Conditions: Neurodevelopmental Abnormality
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