Illinois is currently home to 2642 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell Carcinoma
NCT03787602
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Merkel Cell Carcinoma (MCC) who have failed treatment with at least one anti-PD-1 or anti-PD-L1 immunotherapy or in combination with avelumab in MCC patients who are anti-PD-1 or anti-PD-L1 treatment naïve. Inhibition of MDM2 is a novel mechanism of action in MCC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Northwestern Memorial Hospital, Chicago, Illinois
Conditions: Merkel Cell Carcinoma
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Emicizumab for Severe Von Willebrand Disease (VWD) and VWD/Hemophilia A
NCT05500807
Recruiting
Von Willebrand Disease (VWD) is the most common inherited bleeding disorder affecting up to 0.1% of the population, is usually characterized by mucocutaneous bleeding, HMB, surgical bleeding or other hemostatic challenges. Severe bleeding events require VWF concentrates administered solely through intravenous access. Emicizumab (Hemlibra) is a monoclonal bispecific antibody developed to bind activated FIX and FX and mimic FVIII cofactor functionality. Hemlibra is administered via subcutaneous in... Read More
Gender:
ALL
Ages:
Between 2 years and 90 years
Trial Updated:
02/27/2023
Locations: Bleeding and Clotting Disorders Institute, Peoria, Illinois
Conditions: Von Willebrand Disease, Type 3, Concomitant VWD and Hemophilia
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LIFT Intervention in Liver Transplant Candidates
NCT04836923
Recruiting
Frailty is a significant problem in patients undergoing liver transplant and is associated with poor outcomes and survival. Hence, optimizing physical fitness and counteracting frailty is important. However, many interventions are very resource intensive and therefore not feasible. In this study, the investigators aim to test the effectiveness of a newly designed intervention to improve frailty in liver transplant candidates. The "LIver FrailTy" intervention (LIFT) will consist of an evaluation... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2023
Locations: Northwestern Medicine, Chicago, Illinois
Conditions: Frailty, Cirrhosis, Liver Transplant
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Preventing Tipping Points in High Comorbidity Patients: A Lifeline From Health Coaches
NCT04176510
Recruiting
This pragmatic cluster randomized clinical trial (cRCT) aims to evaluate the comparative effectiveness (CER) of two approaches to preventing destabilization ("tipping points") that lead to unplanned hospitalization and increased disability. The cRCT compares the outcomes of patients randomized in clusters by site within four Federally Qualified Health Center (FQHC) networks in New York City (NYC) and Chicago to either: 1) the Patient Centered Medical Home (PCMH); or 2) the Patient Centered Home... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2023
Locations: Friend Health, Inc., Chicago, Illinois
Conditions: Comorbidity, Self-Management
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Rett Syndrome Registry
NCT05432349
Recruiting
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence Network medical directors, this study collects data on the signs and symptoms of Rett syndrome as reported by the Rett syndrome experts and by the caregivers of individuals with Rett syndrome. This study will be used to develop consensus based guidelines for the care of your loved ones with Rett s... Read More
Gender:
ALL
Ages:
Between 0 years and 99 years
Trial Updated:
01/09/2023
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Rett Syndrome, Rett Syndrome, Atypical, Genetic Disease, Genetic Diseases, X-Linked, Intellectual Disability, Neurobehavioral Manifestations, Neurologic Manifestations, Neurologic Disorder, Neurodevelopmental Disorders, Nervous System Diseases
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I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy
NCT05537922
Recruiting
I3LUNG is an international project aiming to develop a medical device to predict immunotherapy efficacy for NSCLC patients using the integration of multisource data (real word and multi-omics data). This objective will be reached through a retrospective - setting up a transnational platform of available data from 2000 patients - and a prospective - multi-omics prospective data collection in 200 NSCLS patients - study phase. The retrospective cohort will be used to perform a preliminary knowledg... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/05/2023
Locations: University of Chicago, Chicago, Illinois
Conditions: Non Small Cell Lung Cancer, Lung Cancer Metastatic, Lung Cancer, Nonsmall Cell, Lung Adenocarcinoma
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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
NCT01696721
Recruiting
In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it is associated with less severe long term side effects. However, there is limited published data demonstrating these results. The goal of the Proton and Photon Consortium Registry (PPCR) is to enroll children treated with radiation in order to describe the population that... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
01/05/2023
Locations: Northwestern Medicine Chicago Proton Center, Warrenville, Illinois
Conditions: Pediatric Patients Treated With Radiation Therapy
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Comparing Intubation Rates in the Delivery Room by Interface
NCT05609773
Recruiting
Although the majority of premature neonates \< 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined. Preferably this support would be provided by non-invasive means to prevent the development of bronchopulmonary dysplasia. Resuscitation with a face mask, single nasal tube, nasal prongs, and/or LMA are all approved methods of resuscitation per NRP as of 2010. Face masks have been associated with more dead space, air le... Read More
Gender:
ALL
Ages:
Between 0 weeks and 30 weeks
Trial Updated:
12/15/2022
Locations: University of Illinois College of Medicince, Peoria, Illinois
Conditions: Ventilator Lung; Newborn
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Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
NCT05576896
Recruiting
This is a Phase II, open label, single-arm trial study of adding hydroxychloroquine to encorafenib and cetuximab in patients with metastatic BRAF V600E colon cancer with progression on at least 1 prior line of therapy. We hypothesize that autophagy is a major mechanism of resistance to BRAF inhibition in stage IV BRAF V600E colorectal cancer, and that the addition of hydroxychloroquine to standard encorafenib and cetuximab therapy will help overcome this resistance.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/16/2022
Locations: Northwestern University, Chicago, Illinois
Conditions: Stage IV Colorectal Cancer Positive for BRAF V600E Mutation, Colorectal Cancer, Colorectal Cancer Stage IV
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SVS VQI TransCarotid Revascularization Surveillance Project
NCT02850588
Recruiting
The VQI TCAR Surveillance Project is designed to monitor the safety and effectiveness of stents placed directly into the carotid artery while reversing blood flow within the carotid artery to reduce stroke risk. It will compare this less-invasive surgical procedure with standard carotid endarterectomy in centers that participate in the Society for Vascular Surgery Vascular Quality Initiative.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/05/2022
Locations: Society for Vascular Surgery Patient Safety Organization, Chicago, Illinois
Conditions: Carotid Artery Disease
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Progressive Myopia Treatment Evaluation for NaturalVue Multifocal Contact Lens Trial
NCT05159765
Recruiting
This is a multi-center, randomized, double-masked clinical trial. All study devices are market approved/cleared in the localities where the study is conducted. Subjects will be randomly assigned to wear NaturalVue Sphere single vision contact lenses (SVCL) or NaturalVue Multifocal (NVMF) soft contact lenses for a total of three years.
Gender:
ALL
Ages:
Between 7 years and 13 years
Trial Updated:
10/03/2022
Locations: North Suburban Vision Consultants, Deerfield, Illinois
Conditions: Myopia
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OEIS Outcome Data Registry
NCT03058913
Recruiting
This registry is created under the sponsorship of the Outpatient Endovascular and Interventional Society (OEIS) to monitor the clinical course and treatment outcomes of patients undergoing office-based endovascular procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2022
Locations: Outpatient Endovascular Interventional Society (OEIS), Hoffman Estates, Illinois
Conditions: Peripheral Arterial Disease
Register for Updates