Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Family Connections
NCT06662357
Recruiting
The Family Connections study, is intended to disrupt disparities in mental health treatment access for children at-risk for childhood trauma (ACEs) and/or serious emotional disturbance (SED). "Family Connections" will use mobile clinical and family support teams to improve mental health outcomes. This clinical innovation, nested in an integrated system-of-care will be piloted for children, ages 3-18 yrs., with SED who receive primary care through Cambridge Health Alliance.
Gender:
ALL
Ages:
Between 3 years and 18 years
Trial Updated:
06/25/2025
Locations: Cambridge Health Alliance, Cambridge, Massachusetts
Conditions: Emotional Disturbance, Behavior Disorders in Children
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Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
NCT06628908
Recruiting
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/25/2025
Locations: Brigham and Women's Hospital (BWH), Boston, Massachusetts
Conditions: Diabetic Peripheral Neuropathic Pain
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PARADIGM - En Bloc Trial With the EndoQuest Endoluminal Surgical (ELS) System
NCT06133387
Recruiting
The objective of this study is to evaluate the safety and effectiveness of the Endoluminal Surgical (ELS) System in subjects undergoing specified transanal endoluminal procedures in the rectum and sigmoid colon. Subjects will undergo endoscopic submucosal dissection (ESD), with or without closure at the discretion of the Investigator, of benign lesions in the rectum and sigmoid colon. The safety and effectiveness outcomes will be assessed intraoperatively and postoperatively at discharge and Da... Read More
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
06/25/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Colorectal Lesion, Colorectal Adenoma, Colorectal Polyp, Rectal Lesion, Rectal Adenoma, Rectal Polyp, Sigmoid; Lesion, Sigmoid Colon Polyp
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Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment
NCT06106191
Recruiting
This study will identify unique signatures that people have which can cause pain by evaluating biological, psychological, and social markers using artificial intelligence. These markers can be used to accurately predict the response of diverse individuals with chronic low back pain (cLBP) to Mindfulness-Based Stress Reduction. This will help enhance clinician decision-making and the targeted treatment of chronic pain. The overall objective is to use a unique machine learning (ML) approach to de... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Chronic Low-back Pain
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Gluten Technology and Education for Celiac Health
NCT06059716
Recruiting
The investigators propose to plan for a multi-center randomized controlled trial (M-RCT) to test the effectiveness of novel gluten detection technologies as an adjunct to telemedicine to manage celiac disease in newly diagnosed adults. If successful, the proposed intervention will improve mucosal recovery, promote a shift in current practice of celiac disease management toward long-term monitoring, and represent a significant step toward reducing the severe physical and psychological consequence... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/25/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Celiac Disease
Register for Updates
Advancing Transplantation Outcomes in Children
NCT06055608
Recruiting
This is a pediatric kidney transplant study comparing the safety and efficacy of an immunosuppressive regimen of belatacept and sirolimus to tacrolimus and Mycophenolate Mofetil (MMF). Two hundred participants will be randomized (1:1) to one of two groups within 24 hours following the transplant procedure. The duration of the study from time of transplant to the primary endpoint is 12-24 months.
Gender:
ALL
Ages:
Between 13 years and 20 years
Trial Updated:
06/25/2025
Locations: Boston Children's Hospital (Site #: 71001), Boston, Massachusetts
Conditions: Kidney Transplant
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COVID-19 Transmission and Morbidity in Malawi
NCT05973084
Recruiting
SARS-CoV-2 transmission was expected to have a devastating impact in sub-Saharan African countries. Instead, morbidity and mortality rates in nearly the whole region are an order of magnitude lower than in Europe and the Americas. To identify what is different requires a better understanding of the underlying immunological substrate of the population, and how these factors affect susceptibility to infection, progression of symptoms, transmission, and responses to SARS-CoV-2 vaccination. Study o... Read More
Gender:
ALL
Ages:
Between 5 years and 75 years
Trial Updated:
06/25/2025
Locations: BU School of Public Health, Global Health Department, Boston, Massachusetts
Conditions: SARS CoV 2 Infection, SARS CoV 2 Vaccination
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Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
NCT05555732
Recruiting
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Metastatic Non Small Cell Lung Cancer
Register for Updates
Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder
NCT05549258
Recruiting
A Phase 2, open-label, multicenter study to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), and safety of inebilizumab in eligible pediatric participants 2 to \< 18 years of age with recently active neuromyelitis optica spectrum disorder (NMOSD) who are seropositive for autoantibodies against aquaporin-4 (AQP4-immunoglobulin \[Ig\]G).
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
06/25/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Neuromyelitis Optica Spectrum Disorder
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Distal Radius Interventions for Fracture Treatment
NCT05131685
Recruiting
This protocol describes a multicenter, prospective randomized superiority trial comparing functional outcomes between children treated with sedated reduction versus no formal reduction.
Gender:
ALL
Ages:
Between 4 years and 10 years
Trial Updated:
06/25/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Fracture Distal Radius
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Ketamine Treatment of Youth Suicide Attempters
NCT04763343
Recruiting
Ketamine, an NMDA antagonist, has been shown to have rapid anti- suicidal effects. However, its safety and efficacy and special populations has not been investigated and documented. Several reports in adults suggest rapid decrease of suicidal ideation. In the last decade there is an alarming increase of the number of suicide attempts in patients ages 14-30. Suicide is the second leading cause of death in this population. Patients with previous history of suicide attempt, are even in a higher ris... Read More
Gender:
ALL
Ages:
Between 14 years and 30 years
Trial Updated:
06/25/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Suicide, Attempted
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Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer
NCT04614103
Recruiting
This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/25/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Metastatic Non Small Cell Lung Cancer
Register for Updates