Massachusetts is currently home to 3148 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)
NCT06489028
Recruiting
The aim of this clinical trial is to investigate the efficacy and safety of allo-APZ2-CVU, administered topically on therapy-resistant non-healing CVUs compared to placebo.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: RHEACELL Clinical Trial Site, Boston, Massachusetts
Conditions: Venous Leg Ulcer
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A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
NCT06481306
Recruiting
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, pH and food effect, and preliminary efficacy of BMS-986470 in healthy volunteers and participants with sickle cell disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Local Institution - 0024, Boston, Massachusetts
Conditions: Anemia, Sickle Cell, Healthy Volunteers
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Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
NCT06291376
Recruiting
The primary objective of this study to evaluate efficacy of ravulizumab compared with placebo on proteinuria reduction and change in eGFR in adult participants with IgAN who are at risk of disease progression.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Research Site, Boston, Massachusetts
Conditions: Immunoglobulin A Nephropathy, IgAN
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Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part a
NCT06223867
Recruiting
This Study will comprehensively evaluate a multi-component suicide prevention technology (Jaspr Health) that facilitates delivery of suicided-related evidence-based practices (EBPs) while replacing wasted waiting time with productive time in the Emergency Departments (EDs). The EBPs satisfy several key performance elements for systems adopting Zero Suicide. A Complementary Randomized Controlled Trial and Real-World Study for Efficacy, Effectiveness, and Implementation Study Design (CREID) will... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: UMass Memorial Health, Worcester, Massachusetts
Conditions: Suicidal Ideation, Suicide Attempt, Self Harm
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Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD
NCT05904028
Recruiting
Home optical coherence tomography- guided treatment versus treat and extend for the management of neovascular age-related macular degeneration.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/18/2025
Locations: Valley Eye Physicians and Surgeons, Ayer, Massachusetts
Conditions: Neovascular Age-related Macular Degeneration
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High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study
NCT05740839
Recruiting
The purpose of this study is to determine whether a 16-week virtual, home-based, high-intensity interval training (HIIT) exercise program will improve physical, cognitive, and emotional health among young adult survivors of pediatric brain tumors. The names of the study interventions involved in this study are/is: * High-Intensity Interval Training (HIIT)
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
02/18/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Pediatric Brain Tumor
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Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social Anxiety
NCT05683223
Recruiting
The purpose of this clinical trial is to answer the question: can the investigators predict which adults with social anxiety disorder (SAD) will successfully respond to treatment? To answer this question, the investigators plan to recruit 190 adult participants who experience extreme forms of social anxiety to undergo brain imaging before and after 12 weeks of group cognitive behavioral therapy (CBT). Adults in the SAD group who do not respond enough to group CBT may be offered the opportunity t... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
02/18/2025
Locations: Center for Anxiety and Related Disorders at Boston University, Boston, Massachusetts
Conditions: Social Anxiety Disorder
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Double Blind, Placebo-controlled Trial to Establish Safety and Efficacy of Ritlecitinib in Celiac Disease Patients in Remission
NCT05636293
Recruiting
Subjects include: aged 18 to 75 years, inclusive, have biopsy-confirmed disease that is clinically inactive as determined by negative celiac disease (CeD) serology and histology (determined via endoscopy at time of screening), have followed a gluten-free diet (GFD) for ≥6 months as reported by the subject, and be human leukocyte antigen (HLA)-DQ2.5 and/or HLA-DQ8 positive. Study involves the following randomized intervention; 10g gluten + 200mg of Ritlecitinib or placebo
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/18/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Celiac Disease
Register for Updates
Behavioral Activation for Independence in Older Veterans
NCT05493241
Recruiting
As Veterans age, chronic health conditions increase their risk of functional limitations, or difficulty completing day-to-day activities independently. Older adults with functional limitations are more likely to be hospitalized or admitted to long-term care facilities. Maintaining independence at home and in the community is a high priority for many older Veterans. The goal of this study is to support the physical, cognitive, and social functioning of older Veterans by developing a program based... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
02/18/2025
Locations: VA Bedford HealthCare System, Bedford, MA, Bedford, Massachusetts
Conditions: Functional Independence
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Resistance Exercise Combined With Protein Supplementation in People With Pancreatic Cancer: The RE-BUILD Trial
NCT05356117
Recruiting
The purpose of this research is to determine whether a virtually supervised resistance exercise (RE) intervention combined with protein supplementation (PS) is feasible in pancreatic cancer patients initiating chemotherapy and if it will improve skeletal muscle mass. The names of the study interventions involved in this study are: * Resistance training and protein supplement intake (RE + PS) * Resistance training (RE) * Attention control (AC), home-based stretching
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Pancreatic Cancer
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Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents
NCT05347771
Recruiting
This is a multi-center, double-blind, placebo-controlled, randomized trial of dupilumab adjunctive therapy for prevention of asthma exacerbations in urban children and adolescents with T2-high exacerbation-prone asthma.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
02/18/2025
Locations: Boston Children's Hospital: Department of Immunology, Boston, Massachusetts
Conditions: Asthma
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The Autism Biomarkers Consortium for Clinical Trials: Confirmation Study
NCT05294705
Recruiting
This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for potential use in clinical trials. The confirmation study will repeat the data collection and analysis protocols from the original ABC-CT study. This confirmation study will recruit 200 ASD and 200 TD comparison participants who are 6-11 years old, matching the overall sampl... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
02/18/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Autism Spectrum Disorder
Register for Updates