Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Integrated Treatment for Enhancing Growth in Recovery During Adolescence
NCT06395467
Recruiting
This is a Phase II parallel group randomized controlled trial with 294 adolescents (age: 14-21 years) with alcohol and other drug \[AOD\] use disorder (hereafter substance use disorder), that compares two different active psychosocial interventions designed to address adolescent substance use disorder. Participants are recruited from our clinical settings and the community at two sites: one in the metro Boston, Massachusetts (MA) area and the other in the metro Farmington, Connecticut (CT), area... Read More
Gender:
ALL
Ages:
Between 14 years and 21 years
Trial Updated:
04/23/2025
Locations: MGH Department of Psychiatry, Boston, Massachusetts
Conditions: Alcohol Use Disorder, Cannabis Use Disorder
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A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis
NCT06329401
Recruiting
A randomized, double-blind, placebo-controlled clinical study to evaluate the safety and efficacy of 2 doses of inhaled pirfenidone (AP01) versus placebo on top of standard of care in participants with PPF over 52 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Progressive Pulmonary Fibrosis
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Tshireletso: Safety, Efficacy and Feasibility of Cabotegravir-LA PrEP in a Breastfeeding Population in Botswana
NCT05986084
Recruiting
The goal of this this hybrid safety/implementation study is to evaluate whether using long-acting cabotegravir (CAB-LA) for HIV prevention (PrEP) is acceptable, feasible and safe in post-partum people who are breastfeeding. The main question\[s\] it aims to answer are: * Will CAB-LA injections work well as a way to prevent HIV infection in post-partum people? * Will CAB-LA injections be safe in post-partum people and their infants who will be breastfeeding? Participants without HIV who are adm... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Pre-Exposure Prophylaxis (PrEP), Breast Feeding
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ALS/MND Natural History Study Data Repository
NCT05966038
Recruiting
This is a data repository for multi-site multi-protocol clinic-based Natural History Study of ALS and Other Motor Neuron Disorders (MND). All people living with ALS or other MNDs who attend clinics at the Study hospitals (sites) are offered to participate in the Study. The Sites collect so-called Baseline information including demographics, disease history and diagnosis, family history, etc. At each visit, the Sites also collect multiple disease-specific outcome measures and events. The inform... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/23/2025
Locations: Lahey Clinic, Burlington, Massachusetts
Conditions: ALS, PLS, MND (Motor Neurone DIsease), Kennedy Disease, PMA - Progressive Muscular Atrophy, PBP - Progressive Bulbar Palsy
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SAfety of Regional Citrate Anticoagulation (SARCA Study)
NCT05339139
Recruiting
This is an Open-label, Prospective, Multicenter Study to Assess the SAfety of Regional Citrate Anticoagulation Delivered by the multiFiltratePRO system in Adult Patients Requiring Continuous Renal Replacement Therapy (SARCA Study).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: UMass Memorial Medical Center, Worcester, Massachusetts
Conditions: Acute Kidney Injury, ESRD
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The Re-Prosper HF Study
NCT04551222
Recruiting
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of physical and mental health status and carries a high risk of mortality. Even though significant progress has been made in understanding the disease process, currently, its management and treatment is limited. The investigators have discovered that a commonly used drug for the treatment of gout can be repurposed for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Heart Failure
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Pulmonary Hemodynamics During Exercise - Research Network
NCT03954574
Recruiting
The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Massachusetts General Hospital, Cardiology Division and Pulmonary Unit, Boston, Massachusetts
Conditions: Pulmonary Circulation Diseases
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A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
NCT06940843
Recruiting
The goal of this clinical trial is to learn if the novel Hopeful and Healthy Living (HHL) psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle activities. The HHL intervention using social skills training and training in cognitive self-management strategies in order to help older adults build healthy lifestyle and social routines. We predict that: * Individuals who participa... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
04/22/2025
Locations: Bay Cove Center Club, Boston, Massachusetts
Conditions: Serious Mental Illness, Older Adults
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The Role of Occupational Therapy for Improving Medication Management for Persons With AMD, DR and Glaucoma
NCT06593405
Recruiting
The goal of this clinical trial is to learn if education about additional task lighting, enhanced contrast, enlarged print instructions, smart apps and organizational strategies will improve medication management skills. The main questions it aims to answer are: Does additional task lighting, enhanced contrast, enlarged print instructions, smart apps and organizational strategies improve medication management skills, reduce errors and improve functional use of remaining vision for this task? P... Read More
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
04/22/2025
Locations: MCPHS 10 Lincoln Square, Worcester, Massachusetts
Conditions: Age-Related Macular Degeneration
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Mitigating the Impact of Stigma and Shame Among MSM Living With HIV and Substance Use Disorders
NCT05934305
Recruiting
Men who have sex with men (MSM), and gender minority individuals who have sex with men, living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes. This hybrid type 1 study will assess the efficacy, mechanisms, as well as facilitators and barriers to implementing the MATTER intervention, a virtually delivered 5-session text-enhanced psychobehavioral intervention designed to facilitate viral suppress... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Fenway Health, Boston, Massachusetts
Conditions: Hiv, Substance Use Disorders
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Changes of Soft Tissue Grafting: A Randomized Study
NCT05633511
Recruiting
To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment. Sometimes patient don't want to have second surgical site in their mouth and at the same time do not want to use alternative tissue from human or animal donor. Using patients' blood and preparing it as a membrane is the next best thing to correct gum recession.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Tufts University School of Dental Medicine, Boston, Massachusetts
Conditions: Gingival Recession
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Immuno-PRISM (PRecision Intervention Smoldering Myeloma)
NCT05469893
Recruiting
The purpose of this study is to test the anti-cancer activity of Teclistamab and to compare it with Lenalidomide + Dexamethasone combination in people with high risk smoldering multiple myeloma. People with smoldering multiple myeloma (SMM) usually do not have symptoms but are at risk for progressing to active multiple myeloma (MM). Multiple Myeloma is a cancer of the plasma cells, which are an important part of the immune system. Patients with active multiple myeloma generally require treatmen... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: High-risk Smoldering Multiple Myeloma, Smoldering Multiple Myeloma, Multiple Myeloma
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