Massachusetts is currently home to 3149 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Investigating Exercise in Myotonic Dystrophy Type 2 (DM2)
NCT06716931
Recruiting
An exercise regimen (PRIME: Proximal Resistance In-House Movement Exercise) has been designed for patients with myotonic dystrophy type 2 (DM2). The hypothesis is that this patient-friendly physical therapist (PT)-guided exercise program associates with improved functional capacity and muscle composition in DM2 in this two-period two-sequence cross-over study. Thus, participant will be randomized to one of the three possible groups. Participants in GROUP A will perform exercise routine in clinic... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/03/2024
Locations: Neuromuscular Diagnostic Center. Massachusetts General Hospital, Boston, Massachusetts
Conditions: Myotonic Dystrophy 2
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PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery
NCT06089083
Recruiting
This study seeks to understand how frailty, a term that describes people who are more vulnerable stressors such as a new medical problem, affects the outcomes and quality of life in adult patients with gynecologic cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Malignant Female Reproductive System Neoplasm, Gynecologic Cancer, Gynecologic Neoplasm
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A Multi-Site Leukopak Repository Providing Annotated Biospecimens for Approved Investigator-Directed Biomedical Research Initiatives
NCT05794217
Recruiting
To collect, preserve, and distribute annotated leukopak biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and preventative methods for specific and complex conditions. This protocol will be utilized to collect research grade products that are not meant for transfusion.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
12/03/2024
Locations: Sanguine Biosciences, Waltham, Massachusetts
Conditions: Rare Diseases
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Enhancing Information Management for Young Adults After Genetic Cancer Risk Testing
NCT05759143
Recruiting
This research is being done to develop the electronic platform Nest for young adults (ages 18-39) who have had prior cancer genetic testing. The platform will give patients and their clinicians access to continuously updated information about both pathogenic variants and variants of uncertain significance (VUS). The name of the intervention used in this research study is: Nest portal (electronic platform for patients and clinicians)
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
12/03/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Genetic Predisposition to Disease, Genetic Predisposition
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Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients
NCT05725928
Recruiting
The investigator proposes to conduct a randomized trial of supervised ambulation delivered by mobility technician (MT) up to three times daily, including weekends, to hospitalized medical patients. The aims of the study are to compare the short and intermediate-term outcomes of patients randomized to the intervention versus those patients randomized to receive usual care, to identify patients who are most likely to benefit from the intervention and to assess whether the intervention increases or... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/03/2024
Locations: Baystate Medical Center, Springfield, Massachusetts
Conditions: Mobility Limitation, Frailty, Hospital Acquired Condition, Weakness, Muscle
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A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer
NCT05710848
Recruiting
This is a first-in-human (FIH), Phase 1/2a, multi center, open-label, single treatment, dose escalation and expansion study designed to determine the safety and tolerability of STM-416 in patients with bladder cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Non-muscle-invasive Bladder Cancer
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Nutrition for Precision Health, Powered by the All of Us
NCT05701657
Recruiting
The goal of this investigational study is to develop algorithms that predict human response to foods. The main question it aims to answer are: * How does varying foods and eating patterns impact one's biological and physiological responses? * In what ways can novel dietary assessment measures be used to improve dietary assessments and to prescribe assessments to people in future research with increased precision? * Can artificial intelligence and machine learning techniques be combined to presc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Tufts University, Boston, Massachusetts
Conditions: Nutrition, Health, Dietary Habits
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Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients
NCT05699603
Recruiting
This phase IIA study evaluates the effects of calcipotriene plus 5- fluorouracil immunotherapy for skin cancer prevention in organ transplant recipients. Solid organ transplant recipients are at high risk of developing skin cancer. Actinic keratosis (AK), is a premalignant skin lesion that can progress to squamous cell skin cancer. In this study, solid organ transplant recipients with multiple AKs are treated with topical calcipotriene and 5-FU to evaluate how effective this therapy is against A... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Actinic Keratosis
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Metastatic Leiomyosarcoma Biomarker Protocol
NCT05653388
Recruiting
Leiomyosarcoma (LMS) is one of the most prevalent soft tissue sarcomas (STS) and can occur in various sites including soft tissue, uterus and retroperitoneal large vessels. Metastatic disease occurs in approximately 50% of patients diagnosed with leiomyosarcoma and prognosis is poor in setting of metastatic disease. A minority of patients benefit from treatment with chemotherapy and early biomarkers of benefit from treatment are lacking. A biomarker of tumor response and patient survival benefit... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/03/2024
Locations: Dana- Farber, Boston, Massachusetts
Conditions: Leiomyosarcoma
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Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
NCT05624268
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Massachusetts Medical School, North Worcester, Massachusetts
Conditions: Treatment Resistant Depression
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A Survey to Assess Participants' and Physicians' Knowledge, Attitudes and Behavior When Using GATTEX
NCT05561647
Recruiting
The main aim of this study is to document the level of knowledge and assess attitudes and behaviors of both participants and physicians regarding the risks and safe use of GATTEX. The survey will be done via internet, telephone, or paper and both physicians and participants will be able to choose the method that is preferred. No study medicines will be provided to participants in this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Shire-NPS Pharmaceuticals, INC., Lexington, Massachusetts
Conditions: Short Bowel Syndrome (SBS)
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Studying the Neuronal Basis of Human Social Cognition
NCT05324579
Recruiting
This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Neurosciences
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