Massachusetts is currently home to 3150 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Improving Memory in Alzheimer's Disease with Noninvasive Brain Stimulation
NCT06094192
Recruiting
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
11/06/2024
Locations: 677 Beacon St. Room 308, Boston, Massachusetts
Conditions: Alzheimer Disease
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Pirtobrutinib and Venetoclax in Waldenström Macroglobulinemia
NCT05734495
Recruiting
This study is being done to examine the safety and effectiveness of pirtobrutinib combined with venetoclax as a possible treatment for participants with Waldenström Macroglobulinemia (WM). The names of the study drugs involved in this study are: * Pirtobrutinib (a Noncovalent Bruton Tyrosine Kinase (BTK) inhibitor) * Venetoclax (a BCL2 inhibitor)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: Beth Israel Deaconness Medical, Boston, Massachusetts
Conditions: Waldenstrom Macroglobulinemia
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Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields
NCT04469075
Recruiting
The participants are being treated with Tumor Treating Fields (TTFields) for malignant glioma, and this type of treatment may cause skin-related side effects. This study will test whether using clindamycin and triamcinolone topical lotions can prevent skin-related side effects of TTFields.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Glioblastoma, Skin Toxicity, Recurrent Glioblastoma
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CraniSeal Post Approval Study
NCT06406790
Recruiting
To collect post-approval data comparing the safety and effectiveness of CraniSeal Dural Sealant to DuraSeal Dural Sealant. The study has been powered specifically to determine whether the CraniSeal device when used as an adjunct to sutured dural closure following elective cranial surgery is no worse than (i.e., non-inferior) to the DuraSeal device with respect to proportion of subjects free from post-operative cerebrospinal fluid (CSF) leaks. Additional safety outcomes (i.e., surgical site infec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Leak, Cerebrospinal Fluid
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A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
NCT06115746
Recruiting
The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300 middle and high school students, who have violated their school substance use policies in the past month, as an alternative to punitive school responses for school-based substance use infractions. This randomized controlled trial will test the hypothesis that adolescents rand... Read More
Gender:
ALL
Ages:
Between 9 years and 22 years
Trial Updated:
11/05/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Substance Use, Harm Reduction, Adolescent Behavior
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Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer
NCT06038318
Recruiting
The goal of this study is to find the best way to help participants and families manage the stress of facing a serious illness and be better able to "bounce back" or be resilient after a difficult situation. Participants will take part in the "Promoting Resilience in Stress Management" PRISM program, which is designed to provide skills to change or improve the impact of stress in everyday life. The name of the intervention used in this research study is: -PRISM (a mobile app program comprised... Read More
Gender:
ALL
Ages:
Between 12 years and 25 years
Trial Updated:
11/05/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Stress, Anxiety
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Improving Hallucinations by Targeting the RSTS with TES
NCT05165654
Recruiting
Hallucinations are a core diagnostic feature of psychotic disorders. They involve different sensory modalities, including auditory, visual, olfactory, tactile, and gustatory hallucinations, among others. Hallucinations occur in multiple different neurological and psychiatric illnesses and can be refractory to existing treatments. Auditory hallucinations and visual hallucinations are found across diagnostic categories of psychotic disorders (schizophrenia, schizoaffective, bipolar disorder). Desp... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Hallucinations, Auditory, Psychosis
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Pancreatic Cancer Screening for At-risk Individuals
NCT05006131
Recruiting
The investigators' goal is to conduct a prospective multicenter study to evaluate the yield and outcomes of screening of pancreas cancer in individuals who are at-risk for pancreatic cancer. We plan to use International Cancer of the Pancreas Screening (CAPS3) Consortium recommendations to standardize study population, screening methodology, and study outcomes.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Pancreatic Cancer, Adult
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Scalp Cooling in MBC
NCT04986579
Recruiting
This research is being done to compare rates of hair loss of people with metastatic breast who use scalp cooling versus those who do not use scalp cooling after receiving standard of care treatment with either sacituzumab govitecan, trastuzumab deruxtecan, or eribulin. The name of the study intervention involved in this study is: * Paxman Scalp Cooling System
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Metastatic Breast Cancer, Chemotherapy-induced Alopecia
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Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD
NCT04580420
Recruiting
The aim of this study is to evaluate DCR-PHXC in participants with PH1 and severe renal impairment, with or without dialysis.
Gender:
ALL
Ages:
All
Trial Updated:
11/05/2024
Locations: Clinical Trial Site, Boston, Massachusetts
Conditions: End Stage Renal Disease, Primary Hyperoxaluria Type 1
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Identification of Biomarkers for Patients with Vascular Anomalies
NCT03001180
Recruiting
The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study. The study will also use blood (serum and plasma) and tissue collected and stored in a tissue bank maintained by the Department of Hematology/Oncology.
Gender:
ALL
Ages:
1 day and above
Trial Updated:
11/05/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Vascular Anomaly, Generalized Lymphatic Anomaly, Kaposiform Hemangioendothelioma, Kaposiform Lymphangiomatosis, Gorham-Stout Disease, Klippel Trenaunay Syndrome, Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
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Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
NCT02418442
Recruiting
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
11/05/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Rheumatic Joint Disease
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