Massachusetts is currently home to 3202 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
NCT04045665
Recruiting
The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their ba... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atrial Fibrillation, Stroke, Bleeding
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Responses to Genetic Risk Modifier Testing Among Women With BRCA1/2 Mutations
NCT03396341
Recruiting
The purpose of this study is to describe how women with BRCA1/2 mutations react to genetic risk modifier testing, and to examine how they make decisions about their healthcare.
Gender:
FEMALE
Ages:
25 years and above
Trial Updated:
02/05/2025
Locations: Dana Farber Cancer Institute (Data Collection Only), Boston, Massachusetts
Conditions: Genetic Testing, BRCA1/2
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Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
NCT06817395
Recruiting
Individuals with immune thrombocytopenia (ITP) frequently report difficulties with attention and memory. The main question this study seeks to answer is: Do patients with ITP have evidence of cognitive impairment as detected by a cognitive function test battery? To address this issue, participants will take a cognitive function test and complete surveys on quality of life, fatigue, depression, and cognitive symptoms. The primary aim of the study is to evaluate for the presence and extent of co... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Immune Thrombocytopenia
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Synbiotic to Attenuate Resorption of the Skeleton
NCT06389539
Recruiting
This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women.
Gender:
FEMALE
Ages:
60 years and above
Trial Updated:
02/04/2025
Locations: Hebrew SeniorLife, Roslindale, Massachusetts
Conditions: Osteoporosis, Inflammation, Aging
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Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
NCT05026541
Recruiting
This study aims to investigate the effect of a 15-minute meditation practice on sleep architecture and high-frequency Heart Rate Variability (HF-HRV), as well as cognitive performance after both a well-rested and sleep-deprived night.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/04/2025
Locations: Beth Israel Deaconess Medical Centre, Boston, Massachusetts
Conditions: Sleep, Sleep Deprivation, Cognitive Change
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Detection of Small Fiber Neuropathy Using Skin Properties
NCT04759443
Recruiting
Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating. The detection of nerve damage is complicated and not widely available; it requires either skin biopsy or specialized equipment and training. This project utilizes the mathematical processing of skin pictures for the purpose to extract the statistical features related to l... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Brigham and Women's Faulkner Hospital, Boston, Massachusetts
Conditions: Small Fiber Neuropathy
Register for Updates
A Randomized Multicenter Study for Isolated Skin Vasculitis
NCT02939573
Recruiting
Multi-center sequential multiple assignment randomized trial comparing the effectiveness of three different standard of care treatment options for patients with isolated skin vasculitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Boston University School of Medicine, Boston, Massachusetts
Conditions: Primary Cutaneous Vasculitis, Cutaneous Polyarteritis Nodosa, IgA Vasculitis, Henoch-Schönlein Purpura
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Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer
NCT00872495
Recruiting
The purpose of this study is to determine if analysis of DNA and protein material found in urine will be useful in the detection of urothelial cancer of the bladder and kidney. This analysis may be helpful to determine if how a particular cancer will act regarding remission and recurrence
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Lahey Clinic, Inc., Burlington, Massachusetts
Conditions: Urothelial Cancer, Cancer, Bladder Neoplasms, Urinary Bladder Cancer
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Effects Multimodal Mind and Body Approach for MCI
NCT06814483
Recruiting
The aim of this application is to develop a computer-based multimodal mind and body approach (CMMBA) for mild cognitive impairment (MCI). This product will provide a new, cost-effective and easily accessible treatment option for MCI and potentially other age-related dementia.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/03/2025
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Mild Cognitive Impairment
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Study to Investigate the Efficacy of Abrocitinib in Adult Participants with Severe Fatigue from Post COVID Condition/Long COVID
NCT06597396
Recruiting
The primary purpose of this phase 2a study is to compare the efficacy of abrocitinib to placebo in improving severe fatigue in non-hospitalized adults with symptomatic Post-COVID Condition (PCC) (also called Long COVID). We are also interested in learning if abrocitinib is effective in improving overall health status in people suffering from severe fatigue from PCC. Eligible participants with a confirmed history of COVID19 infection who also have PCC according to the World Health Organization de... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/03/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Post-COVID Condition, Fatigue Symptom
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Biomarkers of AKI in Patients Receiving Daratumumab
NCT06549634
Recruiting
The goal of this prospective observational study is to understand changes in urinary and blood biomarkers associated with acute kidney injury (AKI) in patients newly diagnosed with multiple myeloma and being treated with Daratumumab SC. The aims of the study are: To measure changes in plasma and urinary biomarkers of AKI before initiation of Daratumumab therapy and 30 days after initiation of therapy. To establish whether these biomarkers serve to aid in early detection and prevention of AKI... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Acute Kidney Injury, Multiple Myeloma, Light Chain Nephropathy
Register for Updates
PSMAtrack-tracking Changes in PSMA-PET During Initial Therapy for Metastatic Hormone-sensitive Prostate Cancer
NCT06479187
Recruiting
The goal of this clinical trial is to learn if serial PSMA-PET/CT scans can be used to monitor response to therapy in metastatic hormone sensitive prostate cancer and can be potentially used to optimize future treatment approaches. The main questions it aims to answer are: What is the proportion of men with residual PSMA-avid disease on PET/CT scans after 6 months of treatment for metastatic hormone sensitive prostate cancer? Do the findings on PSMA-PET/CT scans after 6 months of treatment for... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Metastatic Prostate Cancer, Hormone Sensitive Prostate Cancer, Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Register for Updates