Massachusetts is currently home to 3158 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness
NCT04471909
Recruiting
Prospective, non-randomized, multi-center clinical investigation of the NEXUS™ Aortic Arch Stent Graft System (NEXUSTM) for the treatment of thoracic aortic lesions involving the aortic arch with a proximal landing zone, native or previously implanted surgical graft, in the ascending aorta and with a brachiocephalic trunk native landing zone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
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Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices
NCT02050113
Recruiting
The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with complex abdominal aneurysms, aortoiliac aneurysms, thoracoabdominal aneurysms and aortic arch aneurysms who (1) have anatomy not suitable for endovascular repair using grafts currently marketed in the United States,(2) are deemed unsafe to wait the required time necessary for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: UMass Memorial Health Care - University Campus, Worcester, Massachusetts
Conditions: Complex Aortic Aneurysms, Thoracoabdominal Aneurysms, Pararenal Aneurysms, Juxtarenal Aneurysms, Marfan Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome, Aortic Arch Aneurysm
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Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models
NCT06588452
Recruiting
A prospective randomized controlled trial comparing manual review and AI screening for patient eligibility determination and enrollments. A structured query will identify potentially eligible patients from the Mass General Brigham Electronic Data Warehouse (EDW), who will then be randomized into either the manual review arm or the AI-assisted review arm.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/10/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Comparing Manual and AI Patient Screening in Heart Failure
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Head-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies
NCT06417216
Recruiting
This study is investigating whether eye exercises for abducens palsy and internuclear ophthalmoplegia increase ocular range of motion in the paretic direction when performed in virtual reality under head-cancelled compared to head-active conditions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: University of Massachusetts Chan Medical School, Worcester, Massachusetts
Conditions: Internuclear Ophthalmoplegia, Palsy, Abducens
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Forecasting Seizures Using Intelligent Wearable Technology for Health Tracking
NCT06275685
Recruiting
The goal of this interventional study is to develop a personalized seizure risk forecast tool in people with epilepsy. The main questions it aims to answer are: * can we develop a future seizure probabilities tool that is more accurate than chance based on the pattern and frequency of previous generalized tonic-clonic seizure (GTCS) events, as well as changes in physiological and behavioral variables. * does this tool improve the lives of people with epilepsy? Researchers will compare a group... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
09/10/2024
Locations: Empatica, Boston, Massachusetts
Conditions: Epilepsy; Seizure
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Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC
NCT05881304
Recruiting
The goal of this study is to conduct a pilot randomized waitlist-controlled trial to assess the feasibility, acceptability, and preliminary effects of substituting the NIDA standardized research e-cigarette (SREC) for combusted cigarettes in MOUD-TUD who are not ready to quit smoking. A waitlist controlled RCT using a mixed-methods sequential explanatory design will investigate the impact of SREC provision on: 1) tobacco use behavior (e.g., cigarettes per day \[primary outcome\], SREC use), 2) b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Electronic Cigarette Use
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Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors
NCT05407441
Recruiting
This research study involves a combination of three drugs given together as a possible treatment for malignant rhabdoid tumor, atypical teratoid rhabdoid tumor, epithelioid sarcoma, chordoma or other tumors that are deficient in one of two possible proteins, either INI-1 (SMARCB1) or SMARCA4. The names of the study drugs involved in this study are: * Tazemetostat (TAZVERIK) * Nivolumab (OPDIVO) * Ipilimumab (YERVOY)
Gender:
ALL
Ages:
Between 6 months and 21 years
Trial Updated:
09/09/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Atypical Teratoid Rhabdoid Tumor, INI1 (SMARCB1)-Deficient Primary CNS Malignant Tumors, SMARCA4-deficient Primary CNS Malignant Tumors, Malignant Rhabdoid Tumor (MRT), Rhabdoid Tumor of the Kidney (RTK), Epithelioid Sarcoma, Chordoma
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Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers
NCT04416568
Recruiting
This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.
Gender:
ALL
Ages:
Between 6 months and 40 years
Trial Updated:
09/09/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Malignant Rhabdoid Tumor, Rhabdoid Tumor of the Kidney, Epithelioid Sarcoma, Chordoma (Poorly Differentiated or De-differentiated), Atypical Teratoid/Rhabdoid Tumor, Other INI1 Negative Tumors (With PI Approval), Other SMARCA4-deficient Malignant Tumors (With PI Approval)
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YES Study - Newly Diagnosed/Metastatic Intervention
NCT04379414
Recruiting
This research study is being done to monitor common symptoms and behavior, and to provide supportive care information and peer support, as well as research opportunities for young women ages of 18-39 years old who have been diagnosed with stage 0-IV stage breast cancer using a web-based portal (YES), built for smartphones, tablets, and computers.
Gender:
FEMALE
Ages:
Between 18 years and 39 years
Trial Updated:
09/09/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Breast Cancer, Symptom, Behavioral
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TENS Unit for Analgesia During IUD Insertion
NCT06240260
Recruiting
Subjects will be screened over the phone or in Tufts GYN clinic for participation in the study. If eligible and interested in participating, written informed consent (and assent if applicable) will be obtained. After informed consent/assent, the patient will be enrolled in the study. The patient will decide if they desire to use TENS unit during IUD insertion appointment and inform the study team. The clinic visit will proceed as normal, with additional study proceedings as follows. The study pe... Read More
Gender:
FEMALE
Ages:
Between 12 years and 50 years
Trial Updated:
09/06/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: IUD, Analgesia, Patient Preference, Pain, Acute
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Online Tai Chi Plus Fitbit After ACS
NCT05699642
Recruiting
This projects studies the role of tai chi exercise and wearable fitness trackers to promote physical activity in acute coronary syndrome (ACS) survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Acute Coronary Syndrome, Physical Inactivity
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Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers
NCT06196008
Recruiting
This clinical trial compares telephone-based physical activity coaching to self monitored physical activity for improving physical function in older adults who are undergoing surgery for lung cancer and their caregivers. Lung cancer surgery in older adults is associated with functional declines and unique challenges. Performing physical activity around the time of surgery has been shown to improve functional outcomes in patients and exercise programs delivered via telehealth may improve access a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Massachusetts General Hospital (MGH) / Harvard, Boston, Massachusetts
Conditions: Lung Carcinoma
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