Massachusetts is currently home to 3155 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The Osteoarthritis Prevention Study
NCT05946044
Recruiting
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determi... Read More
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
08/20/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Osteoarthritis, Knee
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Impact of Diet on the Gut-Muscle Axis in Older Adults
NCT05549622
Recruiting
Muscle health declines during aging. One factor that may impact muscle health is the community of bacteria that live in our intestines, but studies aimed at improving muscle health by targeting the gut in older adults are sparse. The primary goal of this study is to use a diet that is enriched in soluble fiber, which is exclusively utilized by gut bacteria to make substances that can impact muscle health, to improve muscle-related measures in older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/20/2024
Locations: Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
Conditions: Sarcopenia, Dietary Exposure, Microbial Colonization
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EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
NCT05476276
Recruiting
This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of Painful Diabetic Peripheral Neuropathy (PDPN) in a platform setting to test multiple assets under a single protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: MGH Department of Anesthesia, Critical Care, and Pain, Boston, Massachusetts
Conditions: Painful Diabetic Neuropathy
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rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
NCT04943848
Recruiting
This is a phase I, open label, plus expansion clinical trial evaluating the safety and tolerability of rHSC-DIPGVax in combination with BALSTILIMAB and ZALIFRELIMAB. rHSC-DIPGVax is an off-the-shelf neo-antigen heat shock protein containing 16 peptides reflecting neo-epitopes found in the majority of DIPG and DMG tumors. Newly diagnosed patients with DIPG and DMG who have completed radiation six to ten weeks prior to enrollment are eligible.
Gender:
ALL
Ages:
Between 12 months and 18 years
Trial Updated:
08/20/2024
Locations: Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts
Conditions: Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
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Developing Fast Pediatric Imaging
NCT03761121
Recruiting
This research study is evaluating the investigational software for magnetic resonance imaging (MRI) systems and techniques to process magnetic resonance (MR) images
Gender:
ALL
Ages:
0 years and above
Trial Updated:
08/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pediatric Low-grade Gliomas
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Advanced Fetal Imaging - Phase II
NCT02840019
Recruiting
The goal of Advanced Fetal Imaging - Phase II is to advance fetal MRI imaging by designing MRI coils specifically for pregnant women and testing recently developed MRI image acquisition techniques. The investigators aim to more reliably obtain higher quality fetal MRI images when compared to current clinical fetal MRI.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/20/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pregnancy
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MRI Assessment of Placental Health
NCT02297724
Recruiting
The ultimate goal of this project is to develop methods that allow informed decision-making on the delivery time of fetuses that are at increased risk of stillbirth due to IUGR. In placenta related IUGR pregnancies, there can be multiple concurrent placental pathologies. Although there is no specific correspondence between a single type of pathology and IUGR, the common result of these pathologies is placental insufficiency, which limits the maternal-fetal exchange. Oxygen and nutrition transpor... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/20/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Intrauterine Growth Restriction
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Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia
NCT05587127
Recruiting
Randomized controlled trial of an exposure-based behavioral treatment (CBT) in adults with functional dyspepsia who meet criteria for avoidant/restrictive food intake disorder (ARFID) with weight loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Avoidant/Restrictive Food Intake Disorder, Dyspepsia, Feeding and Eating Disorders, Cognitive Behavioral Therapy, Appetite Regulation, Functional Dyspepsia, Post-prandial Distress Syndrome, Behavioral Medicine
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Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children
NCT05464186
Recruiting
This study will evaluate the effects of whole vs. nonfat milk consumption on body composition, cardiometabolic disease risk factors, and dietary quality.
Gender:
ALL
Ages:
Between 9 years and 12 years
Trial Updated:
08/19/2024
Locations: New Balance Foundation Obesity Prevention Center, Boston, Massachusetts
Conditions: Obesity, Diabetes, Cardiovascular Diseases
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A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB
NCT03530852
Recruiting
Children with inadequate intestinal absorption due to loss of large amounts of small bowel require intravenous nutrition (feeding through the vein) to sustain hydration and nutrition to avoid starvation and dehydration; however, intravenous (IV) nutrition can lead to complications including liver failure. Tube feeding directly to the small intestine avoids the complications of IV nutrition, but fats are not fully digestible due to inadequate bowel function. We propose to predigest the fat using... Read More
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
08/19/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Short Bowel Syndrome, Malabsorption
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Childhood Cancer Survivor Study
NCT01120353
Recruiting
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic mod... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/19/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Cancer
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Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy
NCT05895383
Recruiting
This study is being done to see if nitrous oxide during vasectomy decreases pain and anxiety, and also assess whether patients have better satisfaction when they control their own level of nitrous oxide during the procedure. If we find that patients experience less pain or anxiety with nitrous oxide, it could be suggested that self-adjusted nitrous oxide (SANO) may be a useful tool for improving experience of care during vasectomy.
Gender:
MALE
Ages:
Between 21 years and 85 years
Trial Updated:
08/17/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Procedural Pain, Pain Catastrophizing, Procedural Anxiety
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