Massachusetts is currently home to 3155 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
NCT03152318
Recruiting
This research study is evaluating an investigational drug, an oncolytic virus called rQNestin34.5v.2. This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug as a possible treatment for this diagnosis of recurrent or progressive brain tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Malignant Glioma of Brain, Astrocytoma, Malignant Astrocytoma, Oligodendroglioma, Anaplastic Oligodendroglioma of Brain (Diagnosis), Mixed Oligo-Astrocytoma, Ependymoma, Ganglioglioma, Pylocytic/Pylomyxoid Astrocytoma, Brain Tumor, Glioma, Brain Cancer, Glioblastoma, Glioblastoma Multiforme
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SafeHeal Diverting Ileostomy Pivotal Study
NCT06152276
Recruiting
This SafeHeal study is designed to assess the overall safety of the low anterior resection (LAR) standard of care cancer treatment by establishing a definition of major complications. The current literature on standard of care reports adverse events/complications but does not provide a single endpoint that can be used to compare the safety of LAR cancer treatment to alternative therapies or treatments. This study will allow for the establishment of a new single safety endpoint for LAR standard o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2024
Locations: UMass Memorial Medical Center, Worcester, Massachusetts
Conditions: Colorectal Cancer, Stoma Ileostomy
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Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
NCT04296071
Recruiting
Acute lung injury (ALI) following cardiopulmonary bypass (CPB) is a serious complication, often prolonging the length of stay in ICU and potentially dealing to mortality. The objective of this study is to assess the mechanism of CPB-mediated acute lung injury in pediatric patients.
Gender:
ALL
Ages:
12 months and below
Trial Updated:
08/22/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Lung Injury, Cardiopulmonary Bypass
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Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery
NCT06502002
Recruiting
This will be a randomized, placebo-controlled, double-blinded, pilot trial with two parallel groups (1:1 ratio) receiving either dexmedetomidine (initial bolus of 1 mcg/kg over 30 min after induction, followed by an infusion rate of 0.3 mcg/kg/hr that will be stopped 30-45 minutes before the end of the surgery or upon reaching maximum dose of 2mcg/kg, whichever comes first) or placebo (normal saline as a bolus followed by maintenance infusion at the same rate of the intervention group). Dexmede... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/21/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Surgery-Complications, Respiratory Complication, Lung Injury, Acute
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Neural Mechanisms of Family-Focused Treatment for Youth Depression
NCT06289010
Recruiting
The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused Treatment for Childhood-Depression (FFT-CD) outcomes. The main questions it aims to answer are: * What are differences between depressed and non-depressed participants on baseline neural and parenting indicators? * Do baseline neural and parenting indicators predict respons... Read More
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
08/21/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Childhood Depression
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Optimizing Impact of Manual Therapy on Lumbar Spinal Stenosis
NCT06023498
Recruiting
Lumbar spinal stenosis, a common condition in older adults, can cause pain and difficulty walking (i.e., intermittent neurogenic claudication - INC). Patients with INC not infrequently undergo spinal surgery that fails to help them 1/3-1/2 the time. The purpose of this multi-site feasibility study is to prepare for the conduct of a randomized controlled trial to test the efficacy of manual therapy, exercise, and intramuscular electroacupuncture in reducing pain and improving walking ability for... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/21/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Lumbar Spinal Stenosis
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The Effect of Sleep Loss on Emotion Regulation
NCT05393830
Recruiting
The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions. (i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the processing and regulation of emotional information compared to typical, undisturbed sleep? (ii) What overlapping and distinct neural mec... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
08/21/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Sleep, Insomnia, Sleep Deprivation
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Supporting Treatment Access and Recovery in COD
NCT05138614
Recruiting
This 4-year study will randomize 1,000 people with co-occurring opioid use and mental health disorders (COD) at medication for opioid use disorder (MOUD) clinics to evaluate the effectiveness of MISSION, a multi-component team approach, or its components with MOUD versus MOUD alone, as well as the incremental benefits of MISSION or its components for improving outcomes. We expect that individuals receiving MISSION or its parts + MOUD will show greater improvement over MOUD alone on: engagement,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: Behavioral Health Network, Holyoke, Massachusetts
Conditions: Opioid Use Disorder, Mental Health Disorder
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SBRT + Atezolizumab + Bevacizumab in Resectable HCC
NCT04857684
Recruiting
This study is evaluating the safety and tolerability of neoadjuvant stereotactic body radiation therapy (SBRT) with atezolizumab and bevacizumab for treating resectable hepatocellular carcinoma. This study involves the following study interventions: * Atezolizumab * Bevacizumab * Stereotactic Beam Radiation Therapy (SBRT) * Surgery
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Hepatocellular Carcinoma, Resectable Hepatocellular Carcinoma
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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
NCT04071457
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Multiple Myeloma
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Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
NCT01258231
Recruiting
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.
Gender:
ALL
Ages:
Between 20 years and 90 years
Trial Updated:
08/21/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction, Heart Failure
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TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
NCT00985049
Recruiting
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are... Read More
Gender:
ALL
Ages:
20 years and above
Trial Updated:
08/21/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Cardiovascular Diseases
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