Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Lymphatic Anomalies Registry for the Assessment of Outcome Data
NCT02399527
Recruiting
Lymphatic anomalies are a rare subset of vascular anomalies that are poorly understood. the understanding of the natural history, long-term outcomes, risk factors for morbidity and mortality, and the relative benefit of medical therapies and procedures is limited.The goal of this project is to better understand these diseases and improve the care of theses rare patients. To do this, the investigators are conducting an observational study of patients with lymphatic anomalies, including an annual... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/12/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA), Central Conducting Lymphatic Anomaly, CLOVES Syndrome, Gorham-Stout Disease ("Disappearing Bone Disease"), Blue Rubber Bleb Nevus Syndrome, Kaposiform Lymphangiomatosis, Kaposiform Hemangioendothelioma/Tufted Angioma, Klippel-Trenaunay Syndrome, Lymphangiomatosis
Register for Updates
Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans
NCT06615401
Recruiting
Transgender Veterans (trans Vets) frequently experience gender dysphoria or distress related to discord between their gender identity and birth sex. Gender-affirming treatments (GATs) are medically necessary treatments to reduce gender dysphoria. However, not much is known about the barriers and facilitators that influence GAT access and receipt in VA and VA Community Care (CC), among trans Vets who desire GATs. The goals of this mixed-methods study are to determine which GATs trans Vets receive... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/08/2024
Locations: VA Bedford HealthCare System, Bedford, MA, Bedford, Massachusetts
Conditions: Gender Dysphoria
Register for Updates
Neurophysiologic Biomarkers in Rett Syndrome
NCT05932589
Recruiting
The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity... Read More
Gender:
FEMALE
Ages:
Between 1 year and 18 years
Trial Updated:
11/08/2024
Locations: Boston Children's Hospital, Brookline, Massachusetts
Conditions: Rett Syndrome, RTT, Rett Syndrome, Atypical
Register for Updates
Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM
NCT04653246
Recruiting
This research is testing whether the investigational drug isatuximab is safe and effective when used in combination with standard agents for the treatment of newly diagnosed multiple myeloma.
Gender:
ALL
Ages:
75 years and above
Trial Updated:
11/08/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Multiple Myeloma, Newly Diagnosed Multiple Myeloma (NDMM), Autologous Stem Cell Transplant
Register for Updates
Clinical and Basic Investigations Into Congenital Disorders of Glycosylation
NCT04199000
Recruiting
The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.
Gender:
ALL
Ages:
All
Trial Updated:
11/07/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Disorders of Glycosylation
Register for Updates
Real-world Patient Reported Outcomes Among Patients Treated With Camzyos
NCT06551129
Recruiting
This real-world study will assess changes in health status among participants with symptomatic obstructive hypertrophic cardiomyopathy who are treated with mavacamten in the real world.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/06/2024
Locations: Analysis Group Inc., Boston, Massachusetts
Conditions: Obstructive Hypertrophic Cardiomyopathy
Register for Updates
Improving Memory in Alzheimer's Disease with Noninvasive Brain Stimulation
NCT06094192
Recruiting
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.
Gender:
ALL
Ages:
Between 50 years and 100 years
Trial Updated:
11/06/2024
Locations: 677 Beacon St. Room 308, Boston, Massachusetts
Conditions: Alzheimer Disease
Register for Updates
CraniSeal Post Approval Study
NCT06406790
Recruiting
To collect post-approval data comparing the safety and effectiveness of CraniSeal Dural Sealant to DuraSeal Dural Sealant. The study has been powered specifically to determine whether the CraniSeal device when used as an adjunct to sutured dural closure following elective cranial surgery is no worse than (i.e., non-inferior) to the DuraSeal device with respect to proportion of subjects free from post-operative cerebrospinal fluid (CSF) leaks. Additional safety outcomes (i.e., surgical site infec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Leak, Cerebrospinal Fluid
Register for Updates
A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
NCT06115746
Recruiting
The primary goal of this study is to test the effectiveness of the iDECIDE (Drug Education Curriculum: Intervention, Diversion, and Empowerment) curriculum, a novel drug education and diversion program, in approximately 300 middle and high school students, who have violated their school substance use policies in the past month, as an alternative to punitive school responses for school-based substance use infractions. This randomized controlled trial will test the hypothesis that adolescents rand... Read More
Gender:
ALL
Ages:
Between 9 years and 22 years
Trial Updated:
11/05/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Substance Use, Harm Reduction, Adolescent Behavior
Register for Updates
Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer
NCT06038318
Recruiting
The goal of this study is to find the best way to help participants and families manage the stress of facing a serious illness and be better able to "bounce back" or be resilient after a difficult situation. Participants will take part in the "Promoting Resilience in Stress Management" PRISM program, which is designed to provide skills to change or improve the impact of stress in everyday life. The name of the intervention used in this research study is: -PRISM (a mobile app program comprised... Read More
Gender:
ALL
Ages:
Between 12 years and 25 years
Trial Updated:
11/05/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Stress, Anxiety
Register for Updates
Improving Hallucinations by Targeting the RSTS with TES
NCT05165654
Recruiting
Hallucinations are a core diagnostic feature of psychotic disorders. They involve different sensory modalities, including auditory, visual, olfactory, tactile, and gustatory hallucinations, among others. Hallucinations occur in multiple different neurological and psychiatric illnesses and can be refractory to existing treatments. Auditory hallucinations and visual hallucinations are found across diagnostic categories of psychotic disorders (schizophrenia, schizoaffective, bipolar disorder). Desp... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Hallucinations, Auditory, Psychosis
Register for Updates
Pancreatic Cancer Screening for At-risk Individuals
NCT05006131
Recruiting
The investigators' goal is to conduct a prospective multicenter study to evaluate the yield and outcomes of screening of pancreas cancer in individuals who are at-risk for pancreatic cancer. We plan to use International Cancer of the Pancreas Screening (CAPS3) Consortium recommendations to standardize study population, screening methodology, and study outcomes.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Pancreatic Cancer, Adult
Register for Updates