Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
NCT06538376
Recruiting
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second. It is coupled with an analytical software that allows it to provide more advanced measures of lung motion, ventilation, and perfusion compared to traditional chest radiography. While implementation of DDR fixed machines are beginning elsewhere in the US, this trial involves the first applications of an FDA-approved portable DDR machine, for use at the b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion, Acute Rejection of Lung Transplant (Disorder), Airway Obstruction, Rib Fractures, Acute Copd Exacerbation, Asthma COPD, Pulmonary Embolism, Hemothorax, Pneumothorax, Mesothelioma, Diaphragmatic Paralysis
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The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease
NCT06483126
Recruiting
This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease. For the purpose of this survey, "natural environment" refers to places that primarily consist of natural elements, such as vegetation, water bodies, and landscapes. This includes greenspaces (such as parks, gardens, neighborhood streets lined with trees, forests, or nature reserves) bluespaces (such as next to beaches, lakes, rivers, ponds, or waterfronts), and desert... Read More
Gender:
ALL
Ages:
Between 40 years and 100 years
Trial Updated:
08/05/2024
Locations: Vision and Cognition Laboratory, Boston University, Boston, Massachusetts
Conditions: Parkinson Disease, Mood, Cognition
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AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention
NCT06235112
Recruiting
AI INFORM is a multicenter randomized trial that will test the hypothesis that providing clinicians information on the presence and amount of coronary artery calcifications (CAC), will result in initiation or intensification of preventive therapies. The study will use a cloud-based artificial intelligence (AI) platform (Nanox.AI) that can analyze non contrast chest CT and estimate the amount of CAC.
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Coronary Artery Disease
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Cerebellar Modulation of Cognition in Psychosis
NCT06107764
Recruiting
The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks). Participants will be asked to perform cognitive tasks (problem-solving) and undergo brain scans before and after transcranial magnetic stimulation (TMS). TMS is a way to non-invasively change brain acti... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/05/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder I, Psychosis
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Feasibility of the AveCure Microwave Ablation Technology for the Bronchoscopic Treatment of Malignant Central Airway Obstructions
NCT06105606
Recruiting
This research is being done to evaluate the feasibility of the AveCure Flexible Microwave destruction of tissue (Ablation) Probe for the treatment of malignant central airway obstruction using a thin, tube-like instrument with a light and a lens for viewing and removing tissue (bronchoscopic). The name of the intervention being used in this research study is: AveCure Flexible Microwave Ablation Probe (handheld, surgical device that delivers microwave energy via flexible probe tip)
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Airway Obstruction, Central Airway Obstruction
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Perception in Parkinson's Disease
NCT05483036
Recruiting
The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to pa... Read More
Gender:
ALL
Ages:
Between 40 years and 110 years
Trial Updated:
08/05/2024
Locations: Vision and Cognition Laboratory, Boston University, Boston, Massachusetts
Conditions: Parkinson's Disease, Visual Hallucination, Perception
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Atezolizumab+Bevacizumab+SBRT in Unresectable HCC
NCT05096715
Recruiting
This research study is evaluating the safety and tolerability of the drugs atezolizumab and bevacizumab with stereotactic body radiation therapy (SBRT) for treating unresectable hepatocellular carcinoma. This study involves the following interventions: * Atezolizumab * Bevacizumab * Stereotactic body radiation therapy (SBRT)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Unresectable Hepatocellular Carcinoma
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Dietary Intervention to Mitigate Adverse Consequences of Night Work
NCT04868526
Recruiting
The goal of this clinical trial is to test whether our dietary intervention can prevent or lessen the negative health effects of night shift work in healthy participants. Participants will: * complete 2 inpatient stays * be provided with identical meals * have frequent blood draws * provide urine, saliva, stool and rectal swab samples
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Dietary Habits
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Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices
NCT04835857
Recruiting
(1) To compare cuff-less wrist wearable radial artery blood pressure measurements utilizing ViTrack(developed by Dynocardia) to the cuff based commercially available blood pressure device, in healthy volunteers with normal or high blood pressure.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/05/2024
Locations: Dynocardia Inc, Newton, Massachusetts
Conditions: Hypertension, Healthy
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Statins In Intracerbral Hemorrhage
NCT03936361
Recruiting
The SATURN trial aims to determine whether continuation vs. discontinuation of statin drugs after spontaneous lobar intracerebral hemorrhage (ICH) is the best strategy; and whether the decision to continue/discontinue statins should be influenced by an individual's Apolipoprotein-E (APOE) genotype. An MRI ancillary study (SATURN MRI), in a subset of SATURN participants , will evaluate the effects of continuation vs. discontinuation of statin drugs on hemorrhagic and ischemic MRI markers of cere... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/05/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Intracerebral Hemorrhage
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The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity
NCT03767426
Recruiting
To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation.... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
08/05/2024
Locations: Tony Cunningham, Boston, Massachusetts
Conditions: Sleep Deprivation, Sleep
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Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
NCT01177618
Recruiting
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.
Gender:
ALL
Ages:
All
Trial Updated:
08/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Chronic Obstructive Pulmonary Disease
Register for Updates