Massachusetts is currently home to 3144 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer
NCT03803553
Recruiting
This research study is comparing two standard of care treatment options based on blood test results for participants who have metastatic colon cancer. The names of the potential treatments involved in this study are: * Active surveillance * FOLFIRI treatment * Nivolumab treatment * Encorafenib/Binimetinib/Cetuximab treatment * Trastuzumab + Pertuzumab
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Metastatic Colon Cancer, Stage III Colon Cancer
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Metastatic Tumor Research and Outcomes Network
NCT02830451
Recruiting
The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with metastatic spine tumor(s).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Harvard Medical School Department of Neurosurgery, Boston, Massachusetts
Conditions: Metastatic Spine Tumor
Register for Updates
Primary Tumor Research and Outcomes Network
NCT02790983
Recruiting
This project aims to establish a network of spine oncology centers dedicated to prospective multicenter research of patients diagnosed with a primary tumor of the spine and will include a comprehensive prospective clinical database which will serve as a shared research platform. Demographic, clinical, diagnostic, and therapeutic variables will be used to answer questions about survival and local recurrence, as well as questions about adverse events (AEs), morbidity data, and health-related quali... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/19/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Spinal Column Tumor
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Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
NCT05881239
Recruiting
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched controls. The main question it aims to answer is whether the AROMHA Brain Health Test could serve as a predictive biomarker of neurodegenerative disorders. This understanding will aid in the development of a noninvasive, cost-effective diagnostic tool that reliably and specifica... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
Register for Updates
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
NCT05040659
Recruiting
The purpose of this study is to learn more about how to better track smell recovery in people who have been infected with the SARS-CoV-2 virus (which causes COVID-19). Many people who have been infected by this virus develop changes in their sense of smell (olfaction). We are interested in measuring smell function objectively via smell cards that test odor intensity, identification, and discrimination. Objective and precise olfactory testing that can be performed in the convenience of one's home... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anosmia, Asymptomatic COVID-19, COVID-19 Respiratory Infection, Influenza, Healthy
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NTS-WBRT in Brain Metastases
NCT05013892
Recruiting
This research is being done to assess the quality of life and symptom burden in participants who receive (normal tissue sparing whole brain radiation therapy (NTS-WBRT). This research study involves: * NTS-WBRT (normal tissue sparing whole brain radiation therapy) * Memantine standard of care drug
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Brain Metastases
Register for Updates
Video Images About Decisions for Ethical Outcomes in the Emergency Department (VIDEO-ED)
NCT04931797
Recruiting
A randomized controlled trial of a video decision aid in the Emergency Department Setting to improve advance care planning documentation.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Emergencies
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Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy
NCT04788628
Recruiting
This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy inpatients with implanted hippocampal electrodes.
Gender:
ALL
Ages:
Between 12 years and 65 years
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Epilepsy
Register for Updates
Postoperative VR for Recovery After Bariatric Surgery
NCT04754165
Recruiting
The objective of this study is to investigate whether the addition of immersive virtual reality (VR) in the immediate postoperative period to an enhanced recovery after surgery (ERAS) protocol could improve postoperative recovery from bariatric surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Bariatric Surgery Candidate, Postoperative Pain, Postoperative Complications
Register for Updates
Intraoperative VR for Older Patients Undergoing TKA
NCT04748549
Recruiting
The objective of this study is to investigate whether the use of virtual reality (VR) during total knee arthroplasty (TKA) can facilitate reductions in intraoperative sedative requirements while maintaining high levels of patient satisfaction as compared to both a music and sham VR + usual care control.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/18/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Total Knee Arthroplasty
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Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress
NCT04541654
Recruiting
The purpose of this research study is to learn more about variants in the TP53 gene both associated with Li-Fraumeni Syndrome (LFS), a hereditary cancer risk condition, and TP53 variants found in the blood for other reasons (e.g. ACE/CHIP and mosaicism).
Gender:
ALL
Ages:
All
Trial Updated:
03/18/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Li-Fraumeni Syndrome, TP53 Gene Mutation, Hereditary Cancer Syndrome, Clonal Hematopoiesis, Mosaicism
Register for Updates
Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
NCT02290834
Recruiting
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
Gender:
FEMALE
Ages:
60 years and above
Trial Updated:
03/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Impaired Cognition, Chemo-brain, Breast Cancer
Register for Updates