Massachusetts is currently home to 3200 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Fremanezumab Treatment of Migraine in Women With Menstrual Migraine Ages 18-45
NCT06173661
Recruiting
The goal of this clinical trial is to learn about how a migraine prevention medicine works for people who have migraines/headaches with their menstrual period. The study includes people ages 18 to 45 who have been diagnosed with migraine and who have a migraine with their menstrual period or those who have migraines with their menstrual period and at other times of the month as well. The main question the study aims to answer are: • Does fremanazemab, an injectable calcitonin gene-related pept... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/14/2024
Locations: Brigham and Women's Health Care Center, Chestnut Hill, Massachusetts
Conditions: Migraine, Menstrual Migraine, Menstrually Related Migraine
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Ketamine for OUD and Suicidal Ideation in the ED
NCT06111339
Recruiting
This is a pilot, double-blind, placebo-controlled randomized clinical trial of individuals with opioid use disorder (OUD) with suicidal ideation in the emergency department (ED) to receive either a single infusion of ketamine 0.8mg/kg (n=25) or saline placebo (n=25). The primary aim is to evaluate the safety of the ketamine treatment. The secondary aim is to determine the preliminary efficacy of opioid- and suicide-related outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Opioid Use Disorder, Suicidal Ideation
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Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
NCT05523817
Recruiting
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualiz... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Major Depressive Disorder
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Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
NCT05161169
Recruiting
This research study is exploring the use of genomic sequencing in the newborn period to screen healthy babies for current and future health risks. The study will enroll a diverse cohort of 500 healthy infants and their parents from Boston, MA; New York City, NY; and Birmingham, AL. A small blood sample will be collected from each infant, and whole genome sequencing will be performed in 1/2 of the cohort following a randomized controlled trial design. 3 months later, the randomization status and... Read More
Gender:
ALL
Ages:
Between 0 months and 12 months
Trial Updated:
05/14/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Genetic Predisposition to Disease, Hereditary Diseases
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IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
NCT04221815
Recruiting
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, util... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerosis
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Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation
NCT03848923
Recruiting
This is a prospective observational study that was designed with the following two Specific Aims: 1. To determine whether the Immature Platelet Fraction percentage (IPF%) and the Immature Platelet Count (IPC) are better predictors of bleeding than the platelet count alone in neonates of different gestational and post-conceptional ages and with different etiologies of thrombocytopenia; and 2. To characterize the effects of neonatal thrombocytopenia and platelet transfusions (PLT Tx) on bleeding... Read More
Gender:
ALL
Ages:
Between 0 days and 6 months
Trial Updated:
05/14/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Neonatal Thrombocytopenia
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Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer
NCT06398639
Recruiting
The goal of this clinical trial is to evaluate a screening method to detect clinically relevant prostate cancer. This clinical trial is using genetic data to determine a man's risk of cancer, together with multiparametric magnetic resonance imaging (mpMRI) to identify men with higher grade cancer. The main questions it aims to answer are: * If genetic data related to prostate cancer used with MRI can identify higher-grade, potentially fatal prostate cancer * What age a MRI is useful clinically... Read More
Gender:
MALE
Ages:
Between 40 years and 69 years
Trial Updated:
05/13/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Prostate Cancer, Polygenic Risk Score
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Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
NCT06326983
Recruiting
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham. The overall aim is to evaluate the efficacy of an opioid anesthetic plan (morphine, ketorolac, and acetaminophen versus an opioid sparing anesthetic plan (dexmedetomidine, ketorolac and acetaminophen) for perioperative analgesia and recovery time in patients undergoing tonsillectomies and tonsillotomies at Boston Children's Hospital Waltham. Secondar... Read More
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
05/13/2024
Locations: Boston Children's Hospital, Waltham, Massachusetts
Conditions: Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction, Anesthesia, Pain
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A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
NCT05543616
Recruiting
The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called variant-adapted BNT162b2 RNA-based vaccine) in healthy children. The trial is divided into 5 individual studies or substudies based on age group and prior history of COVID-19 vaccinations. All participants in each of the 5 sub-studies will receive study vaccine as a shot depending on what group they are in. * Substudy A design: Phase 1 includes participa... Read More
Gender:
ALL
Ages:
Between 6 months and 11 years
Trial Updated:
05/13/2024
Locations: Boston medical Center (investigational Pharmacy Services, IP delivery), Boston, Massachusetts
Conditions: SARS-CoV-2 Virus, Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
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Sex Effects on Blood Pressure With Handgrip Training
NCT06215014
Recruiting
The goal of this intervention is to compare the blood pressure response of young females and males to a single bout of static handgrip exercise before and after static handgrip training (4 weeks). The main questions this study aims to answer are: * Are the lowering blood pressure effects of static handgrip exercise training different between young females and males? * Which factors explain the lowering blood pressure effects of static handgrip training and possible differences between sexes? I... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
05/10/2024
Locations: UMassachusetts Boston, Boston, Massachusetts
Conditions: Blood Pressure
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Defibrotide for the Treatment of Severe COVID-19
NCT04652115
Recruiting
The goal of this study is to evaluate the safety and feasibility of defibrotide in COVID-19 pneumonia.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/09/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Covid19
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SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab
NCT03161431
Recruiting
Cancers attract myeloid-derived suppressor cells (MDSCs) that prevent our own immune responses from destroying the cancer. This study will be the first study to begin to determine if the newly discovered drug SX-682 can block cancers from attracting MDSCs. This first study will enroll participants with melanoma, as melanoma cancer has been shown to be able to attract MDSCs. The study will begin to determine if SX-682 is a safe and effective treatment of melanoma. It is thought that SX-682 will b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/09/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Melanoma Stage Iii, Melanoma Stage Iv
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