Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mind Body Intervention for Long COVID-19
NCT06045338
Recruiting
The goal of this study is to determine if a mind-body intervention can help people suffering from symptoms associated with Long COVID. The study is a randomized trial examining the effectiveness of a mind body intervention in reducing somatic symptoms from Long COVID in participants as compared to usual care and an active control (second mind body intervention). The investigators will secondarily investigate whether the intervention alleviates individual somatic complaints and improves daily fun... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/10/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Long COVID, Post-Acute Sequelae of COVID-19, COVID Long-Haul
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Therapeutic Evaluative Conditioning to Reduce Adolescents' Self-injurious Thoughts and Behaviors During and After Psychiatric Inpatient Hospitalization
NCT05796531
Recruiting
Suicide is the 2nd leading cause of death among adolescents, with the highest risk period for suicide being the month following psychiatric inpatient hospitalization. The investigators propose testing a brief, scalable intervention using evaluative conditioning aimed at reducing suicidal thoughts and behaviors among adolescents during and after inpatient hospitalization. Scalable interventions, such as the one proposed that reduce suicide risk during this markedly high-risk period, could result... Read More
Gender:
ALL
Ages:
Between 12 years and 19 years
Trial Updated:
07/10/2024
Locations: Franciscan Hospital For Children, Inc., Brighton, Massachusetts
Conditions: Self-Injurious Behavior, Suicidal Ideation, Suicide Attempts
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Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults
NCT05304286
Recruiting
The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify; and (4) understand the age-related differences in CPSP. Ultimately, an improved comprehension of mechanisms linked to CPSP will provide finer tools for optimizing the selection of treatments for individual patients. Moreover, data that demonstrates the underlying pathobio... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/10/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Chronic Post-surgical Pain
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NIRS Monitoring in Premature Infants
NCT02601339
Recruiting
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) and/or post-hemorrhagic hydrocephalus (PHH) in comparison to newborns with hydrocephalus of a different etiology (VC) and healthy controls (HC). We hypothesize that baseline cerebral metabolic dysfunction... Read More
Gender:
ALL
Ages:
Between 0 months and 12 months
Trial Updated:
07/09/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Hemorrhage, Premature Infants, Newborn, Hydrocephalus
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Mechanisms of Open and Hidden Placebo in Stroke Recovery
NCT05832567
Recruiting
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Stroke, Hemiparesis
Register for Updates
Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present
NCT03655665
Recruiting
To determine whether the use of topical otic drops intra-operative and post-operative during tympanostomy tube placement reduces the rate of tympanostomy tube occlusion and post-operative otorrhea (ear drainage) during the initial 4-week post-operative period in subjects with no middle ear effusion (fluid behind the ear drum) present at the time of surgery. A within subject controlled study design will be utilized to study this effect. Subjects with absent middle ear effusion who are receiving t... Read More
Gender:
ALL
Ages:
Between 6 months and 10 years
Trial Updated:
07/08/2024
Locations: Boston Children's Hospital at Waltham, Waltham, Massachusetts
Conditions: Otitis Media
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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis
NCT06022939
Recruiting
This phase III trial compares the effect of adding a stem cell transplant with melphalan after completing chemotherapy with daratumumab, cyclophosphamide, bortezomib and dexamethasone (Dara-VCD) versus chemotherapy with Dara-VCD alone for treating patients with newly diagnosed amyloid light chain (AL) amyloidosis. Melphalan is a chemotherapy given prior to a stem cell transplant. Giving chemotherapy before a peripheral blood stem cell transplant helps kill cancer cells in the body and helps make... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/05/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: AL Amyloidosis
Register for Updates
Confirmation of Diet as a Treatment for Gulf War Illness
NCT05675878
Recruiting
This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention. The main objectives of this study are: 1) to confirm previous findings of treatment response to the diet in a larger and more diverse group; 2) to examine how changes in the nervous system may be the reason for improvement; and 3) to identify markers which change in the blood after... Read More
Gender:
ALL
Ages:
Between 50 years and 75 years
Trial Updated:
07/05/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Gulf War Syndrome, Gulf War Illness
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Assess Fibrin in Brains With AD/ADRD
NCT05336695
Recruiting
The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
07/03/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer Disease, Dementia of Alzheimer Type
Register for Updates
The Exercise and Concussion Health Study
NCT06494592
Recruiting
This study aims to investigate the effect of two different physical exercise interventions on the brain, cognition and patient reported outcomes following a mild traumatic brain injury (mTBI) in community-dwelling adults. Physical exercise as an intervention for mTBI has great potential yet there is limited high-quality evidence of its effect. Additionally, while standardized exercise protocols for sport-related concussion exist, a similar program is not available to members of the general publ... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/02/2024
Locations: Northeastern University, Boston, Massachusetts
Conditions: Concussion, Mild, Concussion, Brain, TBI (Traumatic Brain Injury), TBI
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A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer
NCT04486352
Recruiting
This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune checkpoint therapy with atezolizumab in participant with recurrent and/or persistent endometrial cancer. The main protocol provides a platform for genomic screening with homogeneous basic eligibility criteria in order to direct study participants into biomarker-matched study cohorts consisting of testing targeted agents.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/02/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Endometrial Cancer
Register for Updates
Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
NCT06483139
Recruiting
Objective 1: To test whether treatment with plasma exchange improves renal recovery in patients with light chain cast nephropathy Objective 2: To compare renal outcomes among patients treated with plasma exchange versus daratumumab-based regimens versus non-daratumumab based-regimens.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Multiple Myeloma, Light Chain Nephropathy, Acute Kidney Injury
Register for Updates