Massachusetts is currently home to 3207 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Prospective Natural History Study in Uveal Melanoma
NCT04588662
Recruiting
The overall objective of this proposal is to develop and utilize a multicenter UM registry that will, in a longitudinal fashion, capture prospective data in order to characterize the natural history of UM and provide data that will be used to support the development of novel therapies for this disease. The care of patients with UM requires a multi-disciplinary team of physicians that commonly requires the involvement of both radiation oncology and interventional radiology, and is typically direc... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Uveal Melanoma
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NIRS Monitoring in Premature Infants
NCT02601339
Recruiting
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) and/or post-hemorrhagic hydrocephalus (PHH) in comparison to newborns with hydrocephalus of a different etiology (VC) and healthy controls (HC). We hypothesize that baseline cerebral metabolic dysfunction... Read More
Gender:
ALL
Ages:
Between 0 months and 12 months
Trial Updated:
07/09/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Hemorrhage, Premature Infants, Newborn, Hydrocephalus
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Mechanisms of Open and Hidden Placebo in Stroke Recovery
NCT05832567
Recruiting
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2024
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Stroke, Hemiparesis
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Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present
NCT03655665
Recruiting
To determine whether the use of topical otic drops intra-operative and post-operative during tympanostomy tube placement reduces the rate of tympanostomy tube occlusion and post-operative otorrhea (ear drainage) during the initial 4-week post-operative period in subjects with no middle ear effusion (fluid behind the ear drum) present at the time of surgery. A within subject controlled study design will be utilized to study this effect. Subjects with absent middle ear effusion who are receiving t... Read More
Gender:
ALL
Ages:
Between 6 months and 10 years
Trial Updated:
07/08/2024
Locations: Boston Children's Hospital at Waltham, Waltham, Massachusetts
Conditions: Otitis Media
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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis
NCT06022939
Recruiting
This phase III trial compares the effect of adding a stem cell transplant with melphalan after completing chemotherapy with daratumumab, cyclophosphamide, bortezomib and dexamethasone (Dara-VCD) versus chemotherapy with Dara-VCD alone for treating patients with newly diagnosed amyloid light chain (AL) amyloidosis. Melphalan is a chemotherapy given prior to a stem cell transplant. Giving chemotherapy before a peripheral blood stem cell transplant helps kill cancer cells in the body and helps make... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/05/2024
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: AL Amyloidosis
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Confirmation of Diet as a Treatment for Gulf War Illness
NCT05675878
Recruiting
This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention. The main objectives of this study are: 1) to confirm previous findings of treatment response to the diet in a larger and more diverse group; 2) to examine how changes in the nervous system may be the reason for improvement; and 3) to identify markers which change in the blood after... Read More
Gender:
ALL
Ages:
Between 50 years and 75 years
Trial Updated:
07/05/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Gulf War Syndrome, Gulf War Illness
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Assess Fibrin in Brains With AD/ADRD
NCT05336695
Recruiting
The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
07/03/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Alzheimer Disease, Dementia of Alzheimer Type
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The Exercise and Concussion Health Study
NCT06494592
Recruiting
This study aims to investigate the effect of two different physical exercise interventions on the brain, cognition and patient reported outcomes following a mild traumatic brain injury (mTBI) in community-dwelling adults. Physical exercise as an intervention for mTBI has great potential yet there is limited high-quality evidence of its effect. Additionally, while standardized exercise protocols for sport-related concussion exist, a similar program is not available to members of the general publ... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/02/2024
Locations: Northeastern University, Boston, Massachusetts
Conditions: Concussion, Mild, Concussion, Brain, TBI (Traumatic Brain Injury), TBI
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A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer
NCT04486352
Recruiting
This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune checkpoint therapy with atezolizumab in participant with recurrent and/or persistent endometrial cancer. The main protocol provides a platform for genomic screening with homogeneous basic eligibility criteria in order to direct study participants into biomarker-matched study cohorts consisting of testing targeted agents.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/02/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Endometrial Cancer
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Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy
NCT06483139
Recruiting
Objective 1: To test whether treatment with plasma exchange improves renal recovery in patients with light chain cast nephropathy Objective 2: To compare renal outcomes among patients treated with plasma exchange versus daratumumab-based regimens versus non-daratumumab based-regimens.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Multiple Myeloma, Light Chain Nephropathy, Acute Kidney Injury
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Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD
NCT05817825
Recruiting
This study aims to test a remotely delivered IOP program ("SmartIOP") for OUD patients who are hospitalized for serious injection-related infections. This will be a pilot trial to assess the feasibility of the IOP program and examine OUD-related outcomes following discharge from the hospital.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Opioid Use Disorder, Serious Bacterial Infections
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Apple Women's Health Study
NCT04196595
Recruiting
This is an observational longitudinal study to advance the understanding of menstrual cycle and gynecologic health conditions including PCOS, infertility and breast cancer.The study will be hosted within the Research app(available on App Store), which allows a user to find, enroll, and participate in Apple-supported health-related research studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2024
Locations: Harvard T.H. Chan School of Public Health, Boston, Massachusetts
Conditions: Menstrual Cycle, Ovulation, Menstruation, Polycystic Ovary Syndrome, Infertility, Menopause, Reproduction, Reproductive Health
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