Massachusetts is currently home to 3147 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA
NCT06091085
Recruiting
Obstructive sleep apnea (OSA) is a highly prevalent disorder that has major consequences for cardiovascular health, neurocognitive function, risk of traffic accidents, daytime sleepiness, and quality of life. For years, a "classic" model of OSA has been used to describe the disorder, which fails to capture it's complexity. Recently, a model for OSA called drive-dependent OSA was discovered be more prevalent in the OSA population. This drive-dependent OSA is due to ventilation instability that oc... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
03/01/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: OSA
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Genetic Testing Decision Aid
NCT05470920
Recruiting
This is a randomized trial to evaluate the effectiveness of an electronic decision aid tool versus a traditional genetic counselor session for multi-gene panel testing for people with ovarian or pancreatic cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/01/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Epithelial Ovarian Carcinoma, Pancreas Adenocarcinoma
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Physical Activity Monitoring in Myasthenia Gravis
NCT06277830
Recruiting
The goal of this observational study is to evaluate the feasibility of using wearable sensor and digital technologies to measure motor and speech function in adults with autoimmune Myasthenia Gravis (MG). The main question\[s\] it aims to answer are: * To measure the correlation of sensor-based measures of motor function with existing outcome measures including the MG-ADL, MGQOL15r, QMG, MGComposite, and Neuro-QOL Fatigue scales. * To develop and validate tablet-based digital assessments of sp... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/29/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Myasthenia Gravis
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Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas
NCT05130866
Recruiting
This is a two-staged, Phase 2/3, randomized, multi-center study to investigate the efficacy and safety of REC-2282 in patients with progressive NF2 mutated meningiomas.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
02/29/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Neurofibromatosis Type 2
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Sonographic Assessment of Cricoid Pressure
NCT04190524
Recruiting
Examining the effectiveness of cricoid pressure using ultrasound imaging. Pulmonary aspiration of gastric contents during tracheal intubation, although rare in pediatrics, is a potentially catastrophic complication of anesthesia. Cricoid pressure is applied during rapid sequence induction to occlude the esophagus and prevent aspiration of gastric contents. Accumulating evidence in adults suggests that cricoid pressure often is not effective, either because the esophagus normally lies lateral to... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
02/28/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Aspiration; Gastric Contents, Anesthesia, Intubation Complication
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Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
NCT05950607
Recruiting
The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize suspected infection management ( versus usual care) use less antibiotics and fewer burdensome interventions.
Gender:
ALL
Ages:
Between 60 years and 106 years
Trial Updated:
02/27/2024
Locations: Hebrew SeniorLife, Boston, Massachusetts
Conditions: Dementia, Alzheimer Disease, Infections
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Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease
NCT05575037
Recruiting
The overall aim of the study is to determine the clinical efficacy and mechanisms of action of anti-IL-4a (dupilumab) as treatment for patients with Aspirin-Exacerbated Respiratory Disease (AERD).
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/27/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Nasal Polyps, Asthma, Aspirin-Induced, Aspirin-Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma With Nasal Polyps
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Delivery SSO2 Therapy for 60 Min in Anterior MI Patients With PCI ≤ 6 Hours of Symptoms Onset Compared to Standard.
NCT04743245
Recruiting
A multi-center randomized post-approval evaluation of delivery of intracoronary hyperoxemic supersaturated Oxygen therapy for 60 minutes in anterior AMI patients with successful reperfusion (via PCI) within 6 hours after onset of symptoms compared to standard therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Baystate Medical Center, Springfield, Massachusetts
Conditions: Acute Myocardial Infarction, STEMI
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Trial to Evaluate Safety and Tolerability of GP-2250 in Combination With Gemcitabine
NCT03854110
Recruiting
This is a phase 1 first in human, dose escalation trial of GP-2250 administered in combination with gemcitabine in subjects with advanced pancreatic cancer previously treated with 5-fluorouracil-based chemotherapy. Prior radiosensitization with gemcitabine, the use of 5-fluorouracil, FOLFIRINOX or Nab-paclitaxel/gemcitabine in the neoadjuvant setting, and prior pancreaticoduodenectomy (Whipple procedure) is allowed. If prior treatment with gemcitabine was at therapeutic doses, a minimum of 3 mo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Pancreatic Cancer, Adult
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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Boston University Medical Center, Boston, Massachusetts
Conditions: Huntington's Disease
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IBS Skin Patch Test Food Allergy Study
NCT06288672
Recruiting
Participants with IBS are skin patch tested (no needles) to 80 different foods and food additives, compounded for patch testing, in search of food allergies. The testing requires 3 office visits within a 4 or 5 day period. The patches are taped to the back at Visit #. At Visit #2 48 hours later, the patches are removed from the skin and the outside border of each patch is marked with a felt tip marker. At Visit #3 (final visit) 1 or 2 days later, the patch test reading is performed by the doctor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2024
Locations: Adult and Pediatric Dermatology, Marlborough, Massachusetts
Conditions: Irritable Bowel Syndrome
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Gravitas Feeding Tube System Placement Validation in Neonates
NCT05914064
Recruiting
The purpose of this study is to validate the Gravitas Feeding Tube System Placement Algorithm for NICU patients and to evaluate the safety and effectiveness of the Gravitas Feeding Tube in the neonate population for the administration of nutrition, fluids and medications.
Gender:
ALL
Ages:
Between 0 weeks and 18 weeks
Trial Updated:
02/23/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Nasogastric Tube
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