Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD)
NCT03926520
Recruiting
This study will explore the effect of ECT treatments plus usual care (ECT+UC) in reducing severe agitation in patients with moderate to severe dementia including Alzheimer's Disease, Vascular dementia, Frontotemporal dementia, and Dementia with Lewy Bodies. The study will also determine the tolerability/safety outcomes of ECT+UC.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
05/30/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Alzheimer Dementia, Agitation,Psychomotor
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Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech
NCT05437159
Recruiting
Persistent developmental stuttering affects more than three million people in the United States, and it can have profound adverse effects on quality of life. Despite its prevalence and negative impact, stuttering has resisted explanation and effective treatment, due in large part to a poor understanding of the neural processing impairments underlying the disorder. The overall goal of this study is to improve understanding of the brain mechanisms involved in speech motor planning and how these ar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
05/29/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Stuttering, Developmental, Aphasia, Primary Progressive
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Phenotyping Asthma for Bronchial Thermoplasty
NCT03435237
Recruiting
This study will evaluate a new imaging technology, called optical coherence tomography (OCT) to examine the asthmatic airways before and after bronchial thermoplasty, which is a new treatment option for severe asthmatic patients. The aim of this study is to learn more about how airways respond to this new treatment. In the future the investigators hope OCT will aid clinicians in the initial assessment, management and long-term follow up of patients receiving bronchial thermoplasty.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/28/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Severe Asthma
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Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy
NCT05646576
Recruiting
The goal of this study is to determine whether a palliative care intervention (PEACE) can improve the quality of life and experiences of participants with Lymphoma, Leukemia, or Multiple Myeloma receiving adoptive cellular therapy (ACT). After completion of an open pilot, participants will be randomly assigned into one of two study intervention groups. The names of the study intervention groups involved in this study are: * Palliative care (PEACE) plus usual oncology care * Usual care (standar... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Hematologic Malignancy, Blood Cancer, Lymphoma, Leukemia, Multiple Myeloma
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Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
05/24/2024
Locations: Beth Israe Deaconess Medical Center, Boston, Massachusetts
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
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Multisite Implementation of COMPRENDO
NCT06055296
Recruiting
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring multilevel implementation factors that can inform real-world setting implementation. This study will test the impact of COMPRENDO, a peer-navigation intervention, vs. usual care on accrual to childhood cancer therapeutic clinical trials and parental informed consent out... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: Dana Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts
Conditions: Pediatric Cancer
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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
NCT05962879
Recruiting
This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
05/21/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anxiety Disorders, Psychotic Disorders, Depressive Disorder, Psychosocial Functioning
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Slow Heart Registry of Fetal Immune-mediated High Degree Heart Block
NCT04559425
Recruiting
Few studies are specifically designed to address health concerns that are already relevant during pregnancy. The consequence is a lack of evidence on best clinical practice. This includes mothers and their babies when pregnancy is complicated by an abnormally slow heart rate due to maternal antibody-mediated heart disease in the unborn baby (fetus). Since the late seventies, it has been possible to detect and monitor fetal disease by ultrasound images and to treat selected conditions with pharma... Read More
Gender:
FEMALE
Ages:
Between 16 years and 50 years
Trial Updated:
05/21/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Heart Block Complete, Heart Block Second Degree
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A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy
NCT03310918
Recruiting
This research study is evaluating the impact a collaborative palliative care and oncology team will have on end-of-life outcomes, quality of end-of-life care, and the quality of life, symptoms, and mood of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) receiving non-intensive therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndromes
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Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy
NCT01961713
Recruiting
This study will evaluate a method to detect tumor cells that are circulating in the blood without getting a biopsy. The investigators already know from other studies that cancer tumors shed a small number of cells into the bloodstream every day. These are called circulating tumor cells (CTCs). Some early studies indicate the amount and type of CTCs in the blood can help determine the status of the tumor itself and the way it is responding to treatment. In this study, the investigators will compa... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Massachsuetts General Hospital, Boston, Massachusetts
Conditions: Prostate Cancer
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Impact of Cognitive Behavioral Therapy on PTSD-CVD Link
NCT06429293
Recruiting
This is a pilot randomized controlled trial to assess the impact of a first-line treatment for posttraumatic stress disorder (PTSD) (Cognitive Processing Therapy; CPT) versus waitlist control on mechanisms of cardiovascular disease (CVD) risk. Further, this study will test the hypothesis that CPT reduces CVD risk through its effects on inflammation and autonomic function and that these changes are driven by changes in stress-related neural activity (SNA)
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Posttraumatic Stress Disorder
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Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations
NCT05299749
Recruiting
Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/17/2024
Locations: Boston VA Healthcare System, Brockton, Brockton, Massachusetts
Conditions: Schizophrenia, Auditory Hallucination, Treatment-resistant Schizophrenia
Register for Updates