Massachusetts is currently home to 3201 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
05/24/2024
Locations: Beth Israe Deaconess Medical Center, Boston, Massachusetts
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
Register for Updates
Multisite Implementation of COMPRENDO
NCT06055296
Recruiting
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring multilevel implementation factors that can inform real-world setting implementation. This study will test the impact of COMPRENDO, a peer-navigation intervention, vs. usual care on accrual to childhood cancer therapeutic clinical trials and parental informed consent out... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: Dana Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts
Conditions: Pediatric Cancer
Register for Updates
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
NCT05962879
Recruiting
This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings from developing mental illnesses.
Gender:
ALL
Ages:
Between 14 years and 19 years
Trial Updated:
05/21/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anxiety Disorders, Psychotic Disorders, Depressive Disorder, Psychosocial Functioning
Register for Updates
Slow Heart Registry of Fetal Immune-mediated High Degree Heart Block
NCT04559425
Recruiting
Few studies are specifically designed to address health concerns that are already relevant during pregnancy. The consequence is a lack of evidence on best clinical practice. This includes mothers and their babies when pregnancy is complicated by an abnormally slow heart rate due to maternal antibody-mediated heart disease in the unborn baby (fetus). Since the late seventies, it has been possible to detect and monitor fetal disease by ultrasound images and to treat selected conditions with pharma... Read More
Gender:
FEMALE
Ages:
Between 16 years and 50 years
Trial Updated:
05/21/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Heart Block Complete, Heart Block Second Degree
Register for Updates
A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy
NCT03310918
Recruiting
This research study is evaluating the impact a collaborative palliative care and oncology team will have on end-of-life outcomes, quality of end-of-life care, and the quality of life, symptoms, and mood of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) receiving non-intensive therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Acute Myeloid Leukemia, Myelodysplastic Syndromes
Register for Updates
Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy
NCT01961713
Recruiting
This study will evaluate a method to detect tumor cells that are circulating in the blood without getting a biopsy. The investigators already know from other studies that cancer tumors shed a small number of cells into the bloodstream every day. These are called circulating tumor cells (CTCs). Some early studies indicate the amount and type of CTCs in the blood can help determine the status of the tumor itself and the way it is responding to treatment. In this study, the investigators will compa... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/21/2024
Locations: Massachsuetts General Hospital, Boston, Massachusetts
Conditions: Prostate Cancer
Register for Updates
Impact of Cognitive Behavioral Therapy on PTSD-CVD Link
NCT06429293
Recruiting
This is a pilot randomized controlled trial to assess the impact of a first-line treatment for posttraumatic stress disorder (PTSD) (Cognitive Processing Therapy; CPT) versus waitlist control on mechanisms of cardiovascular disease (CVD) risk. Further, this study will test the hypothesis that CPT reduces CVD risk through its effects on inflammation and autonomic function and that these changes are driven by changes in stress-related neural activity (SNA)
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Posttraumatic Stress Disorder
Register for Updates
Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations
NCT05299749
Recruiting
Neurofeedback intervention aimed to regulate the superior temporal gyrus (STG) activation and default mode network (DMN) connectivity as well as to reduce the auditory hallucinations (AH) schizophrenia patients with medication resistant AH.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/17/2024
Locations: Boston VA Healthcare System, Brockton, Brockton, Massachusetts
Conditions: Schizophrenia, Auditory Hallucination, Treatment-resistant Schizophrenia
Register for Updates
REFLECTION: A Clinical Practice Learning Program for Galleri®
NCT05205967
Recruiting
REFLECTION is a multi-center, prospective, non-interventional, cohort study that will enroll approximately 17,000 individuals who have opted to be screened with Galleri®, a blood-based, multi-cancer early detection (MCED) test in routine clinical settings. The purpose of the study is to understand the real-world experience of Galleri® in clinical settings.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
05/17/2024
Locations: Boston VA Research Institute (VA Boston), Boston, Massachusetts
Conditions: Early Detection of Cancer, Cancer
Register for Updates
Genetic Studies of Strabismus, Nystagmus, and Associated Disorders
NCT04770519
Recruiting
Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be enrolled: (1) Families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. Whole exome and/or whole genome sequencing will be used to identify genetic variants shared by fam... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/17/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Strabismus, Nystagmus, Congenital
Register for Updates
Parkinson's Disease in Asian Americans
NCT05532982
Recruiting
The ultimate goal of this project is to use the findings to develop culturally appropriate programs and resources that can be disseminated to key stakeholders to improve access to PD care and increase inclusivity in PD research for Asian Americans. This study will serve as a first step towards developing broader community and patient education programs and active outreach campaigns to increase PD-specific literacy among Asian Americans. The results from this study will elucidate the role that la... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Tufts University School of Medicine, Boston, Massachusetts
Conditions: Parkinson's Disease
Register for Updates
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564
Recruiting
This study is a postmarketing requirement jointly carried out by four NDA holders (Bayer AG, Bracco, GE Healthcare and Guerbet) and the CRO IQVIA. The study aims to create detailed images of the organs and tissue of the human body during x-ray, CT-scan or MRI investigations, doctors are using contrast media (a kind of dye) which can be given to patients by injection into a blood vessel or by mouth. In this study researchers want to find out whether so called gadolinium-based contrast agents (G... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/15/2024
Locations: Massachussets General Hospital, Boston, Massachusetts
Conditions: Motor Function, Cognitive Function, Contrast Media
Register for Updates