Massachusetts is currently home to 3147 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Psychosocial Mobile Application (THRIVE-M) for Patients With Multiple Myeloma
NCT06073353
Recruiting
This clinical trial aims to evaluate whether a psychosocial mobile application (THRIVE-M), is efficacious for improving quality of life, psychological distress, and fatigue in patients living with multiple myeloma compared to usual care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Multiple Myeloma
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Virtual Reality Intervention for Patients Undergoing BMT
NCT05629676
Recruiting
The goal of this research study is to test the feasibility and preliminary efficacy of using a virtual reality (VR) psychosocial intervention for improving quality of life and psychological distress in patients hospitalized for bone marrow transplantation (BMT). Participants will be randomly assigned into one of the study groups: the virtual reality psychosocial intervention (BMT-VR) + usual care versus usual care alone. The BMT-VR intervention has several components: 1. Psychoeducation to enh... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Bone Marrow Transplant Complications
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COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
NCT04354246
Recruiting
Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM902 as monotherapy and in combination with COM701 in subjects with advanced malignancies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2024
Locations: Massachusetts General Hospital., Boston, Massachusetts
Conditions: Advanced Cancer, Ovarian Cancer, Lung Cancer, Colon Cancer, Plasma Cell Neoplasm, Multiple Myeloma, HNSCC, Microsatellite Stable Colorectal Carcinoma, MSS-CRC
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Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's Hospital Boston (UCDC New England Center), Boston, Massachusetts
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
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Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
NCT06265272
Recruiting
A total of fifty-five (55) patients with liver cirrhosis will be enrolled in this study to produce and validate dedicated Ga-PSMA-PET/MRI acquisition protocols. The specific hypotheses include: * Ga-PSMA PET/MRI may allow robust and reproducible noninvasive in vivo quantitation of hepatic macro and microhemodynamics in cirrhotic patients * Dedicated simultaneously acquired DWI sequences might quantitate liver fibrosis and improve hemodynamic quantitation. * Ga-PSMA PET/MRI may allow noninvasiv... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/09/2024
Locations: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
Conditions: Liver Cirrhosis, Hepatic Cell Carcinoma, Portal Hypertension
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MOLAR: Mapping Oral Health and Local Area Resources
NCT05688982
Recruiting
The goal of this clinical trial is to test the impact of a screening and linkage intervention for adverse social determinants of health (aSDoH) on oral health linkage to care for emergency department patients. Researchers will compare three groups: Patients in Arm A will receive paper handouts with general oral health and aSDoH resources. Patients in Arm B will receive paper handouts with geographically-proximate oral health and aSDoH resources. Patients in Arm C will receive geographically-prox... Read More
Gender:
ALL
Ages:
1 year and above
Trial Updated:
02/09/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Dental Diseases
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Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF
NCT05639556
Recruiting
The goal of the study is to examine multiple markers of anthropometrics, body composition, sarcopenia and frailty and compare them to dual energy X-ray absorptiometry (DXA) output, which is considered the current clinical gold-standard tool to measure body composition. The result of this study will provide detailed data regarding the nutrition and body composition within this Cystic Fibrosis population and also provide a baseline evaluation for use of these biomarkers in the future studies inclu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: Massachusetts General Hospital (MGH), Boston, Massachusetts
Conditions: Cystic Fibrosis
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Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.
NCT06252493
Recruiting
In this study twenty-five (25) subjects with Crohn's disease scheduled for possible surgical intervention will be recruited for this study and a PET/MR scan using the collagen-binding radiotracer will be performed. The study aims to establish the performance figures of PET/MR using \[68Ga\]CBP8-PET for preoperative detection and differentiation of strictures with a fibrotic component in patients with Crohn's disease by using surgical and histologic findings (when available) as the standard for c... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/08/2024
Locations: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
Conditions: Crohn Disease
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Pain Reduction and Ovarian Perfusion Following Uterine Fibroid Embolization
NCT06106633
Recruiting
The goal of this study is to assess of Pressure-Enabled Drug Delivery on fibroid treatment in patients undergoing UFE.
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
02/08/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Uterine Bleeding, Uterine Fibroid
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DLL3-Directed Chimeric Antigen Receptor T-cells in Subjects With Extensive Stage Small Cell Lung Cancer
NCT05680922
Recruiting
This is a phase 1, first-in-human, open-label, multicenter, dose escalation and expansion study of DLL3-targeted chimeric antigen receptor T-cells in subjects with extensive stage small cell lung cancer or large cell neuroendocrine lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/08/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Small Cell Lung Cancer Extensive Stage, Large Cell Neuroendocrine Carcinoma of the Lung
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Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas
NCT06132165
Recruiting
This study will evaluate the effectiveness of skin cooling in increasing tolerability of four treatments in Neurofibromatosis Type 1 Cutaneous Neurofibromas. These treatments are: a 980nm laser, a 755nm laser, radio-frequency injection, and a Kybella injection. Each patient will have a treatment and a control site..
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/07/2024
Locations: Wellman Center for Photomedicine, Boston, Massachusetts
Conditions: Neurofibromatosis 1
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Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation
NCT05995899
Recruiting
The aim of this study is to better understand how tenapanor affects the metagenomics and metabolomics of patients with irritable bowel syndrome with constipation (IBS-C). Tenapanor is the newest FDA-approved agent for IBS-C. It is a small molecule that inhibits the NHE3 receptor, leading to impaired sodium and water absorption in the intestine. Previous clinical trials comparing tenapanor to placebo showed that a 50 mg dose of tenapanor led to increased bowel movements and decreased abdominal pa... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/07/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: IBS, IBS - Irritable Bowel Syndrome
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