Massachusetts is currently home to 3175 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Granzyme B PET Imaging Drug as a Predictor of Immunotherapy Response to Checkpoint Inhibitors
NCT04169321
Recruiting
First in Human Safety of \[68Ga\]-NOTA-hGZP PET Imaging in subjects with cancer undergoing treatment with a checkpoint inhibitor either as a monotherapy of in combination I-O therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/17/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Solid Tumor, Unspecified, Adult, Lymphoma
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A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
NCT05599191
Recruiting
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/14/2024
Locations: Infinity Medical Research Inc, North Dartmouth, Massachusetts
Conditions: Refractory Chronic Cough
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Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation
NCT05498181
Recruiting
This randomized placebo-controlled clinical trial will evaluate the effect of sacubitril/valsartan (compared with placebo) on echocardiographic measures of hypervolemia, preservation of residual renal function, and key safety parameters in incident hemodialysis patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Hemodialysis
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A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH
NCT04764474
Recruiting
An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in subjects with advanced relapsed, refractory, or resistant hematological malignancies that harbor IDH mutations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: University of Massachusetts Medical School, Worcester, Massachusetts
Conditions: Isocitrate Dehydrogenase Gene Mutation
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MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)
NCT04428372
Recruiting
This proposal will measure the effects of mannitol administration versus placebo in hypotensive-prone, adult, maintenance hemodialysis patients with respect to changes in patient symptoms and blood pressure stability.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: Brigham and Women's, Boston, Massachusetts
Conditions: Hemodialysis Complication, Hemodynamic Instability
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Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid
NCT04291599
Recruiting
This will be a phase 2, single-center, unblinded randomized controlled pilot trial of two arms comparing opioid-sparing analgesia to the current Boston Children's Hospital institutional practice which has been reported to predominantly include administration of opioids as a first-line analgesic to pediatric patients who present to the emergency department with a diagnosis of acute pancreatitis (AP). This is a pilot trial for which many outcomes have not previously been studied in the pediatric A... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
02/13/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Acute Pancreatitis
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Adjunctive Mindfulness During Opioid Tapering for patientS With Chronic Pain (The AMOS Study)
NCT06268522
Recruiting
This study is a Randomized Controlled Trial exploring the effects of a Mindfulness interventions in reducing pain interference and opioid dose in patients with Chronic Low Back Pain. A total of 200 opioid-using patients with chronic pain, male and female participants will be enrolled, with a need for 160 completers. Patient will be randomly assigned into the Mindfulness-Oriented Recovery Enhancement or the Psychoeducation comparison control group.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/12/2024
Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts
Conditions: Low Back Pain
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Psychosocial Mobile Application (THRIVE-M) for Patients With Multiple Myeloma
NCT06073353
Recruiting
This clinical trial aims to evaluate whether a psychosocial mobile application (THRIVE-M), is efficacious for improving quality of life, psychological distress, and fatigue in patients living with multiple myeloma compared to usual care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Multiple Myeloma
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Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's Hospital Boston (UCDC New England Center), Boston, Massachusetts
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
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Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
NCT06265272
Recruiting
A total of fifty-five (55) patients with liver cirrhosis will be enrolled in this study to produce and validate dedicated Ga-PSMA-PET/MRI acquisition protocols. The specific hypotheses include: * Ga-PSMA PET/MRI may allow robust and reproducible noninvasive in vivo quantitation of hepatic macro and microhemodynamics in cirrhotic patients * Dedicated simultaneously acquired DWI sequences might quantitate liver fibrosis and improve hemodynamic quantitation. * Ga-PSMA PET/MRI may allow noninvasiv... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/09/2024
Locations: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts
Conditions: Liver Cirrhosis, Hepatic Cell Carcinoma, Portal Hypertension
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MOLAR: Mapping Oral Health and Local Area Resources
NCT05688982
Recruiting
The goal of this clinical trial is to test the impact of a screening and linkage intervention for adverse social determinants of health (aSDoH) on oral health linkage to care for emergency department patients. Researchers will compare three groups: Patients in Arm A will receive paper handouts with general oral health and aSDoH resources. Patients in Arm B will receive paper handouts with geographically-proximate oral health and aSDoH resources. Patients in Arm C will receive geographically-prox... Read More
Gender:
ALL
Ages:
1 year and above
Trial Updated:
02/09/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Dental Diseases
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Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF
NCT05639556
Recruiting
The goal of the study is to examine multiple markers of anthropometrics, body composition, sarcopenia and frailty and compare them to dual energy X-ray absorptiometry (DXA) output, which is considered the current clinical gold-standard tool to measure body composition. The result of this study will provide detailed data regarding the nutrition and body composition within this Cystic Fibrosis population and also provide a baseline evaluation for use of these biomarkers in the future studies inclu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2024
Locations: Massachusetts General Hospital (MGH), Boston, Massachusetts
Conditions: Cystic Fibrosis
Register for Updates