Massachusetts is currently home to 3208 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MBG453 in Lower Risk MDS
NCT04823624
Recruiting
This research study is assessing the efficacy of MBG-453, a humanized monoclonal antibody, in treating myelodysplastic syndromes (MDS). The name of the study drug involved in this study is MBG453.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Myelodysplastic Syndromes
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Calcitriol Monotherapy for X-Linked Hypophosphatemia
NCT03748966
Recruiting
Children and adults with XLH recruited will be treated with calcitriol alone (without phosphate supplementation) for one year, during which the calcitriol dose will be escalated during the first 3 months of therapy. The investigators hypothesize that treatment of adults and children with XLH alone will improve serum phosphate levels and skeletal mineralization without causing an increase in kidney calcifications. The study will also examine if calcitriol therapy will improve growth in children.
Gender:
ALL
Ages:
Between 3 years and 70 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: X-linked Hypophosphatemia, Hypophosphatemic Rickets, Hypophosphatemic Rickets, X-Linked Dominant
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A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
NCT02118922
Recruiting
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
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Speech Treatment for Minimally Verbal Children With ASD and CAS
NCT05066178
Recruiting
Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech.
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
03/10/2024
Locations: MGH Institute of Health Professions, Boston, Massachusetts
Conditions: Developmental Verbal Dyspraxia, Autism Spectrum Disorder
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MRI Guided Prostate Biopsy
NCT06302595
Recruiting
This study aims to assess the feasibility of magnetic resonance (MR) guided prostate biopsy using a needle holder frame. This frame is used to help position the needle used for the biopsy. The feasibility in this study is defined as whether the needle holder frame enables accurate tissue sampling from a suspicious region in the prostate found on an MR image. If it does, a biopsy can be carried out with the needle holder frame safely in a clinical routine. The study will be conducted during a rou... Read More
Gender:
MALE
Ages:
30 years and above
Trial Updated:
03/08/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Suspected Prostate Cancer
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Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy
NCT06300450
Recruiting
This single-center, 400-patient, randomized controlled trial assesses the impact of a patient- and provider-facing EPIC Best Practice Advisory (BPA; alert-based computerized decision support tool) to increase guideline-directed utilization of statin and statin-alternative oral LDL-C lowering therapies in patients with PAD who are not being prescribed LDL-C-lowering therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Peripheral Artery Disease, Peripheral Vascular Diseases, Dyslipidemias
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Emergency Care at Home
NCT06299774
Recruiting
This study will assess the efficacy of receiving emergency care at home versus in the brick-and-mortar emergency department.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Emergency Medical Services, Emergency Department Visits
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A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
NCT06296966
Recruiting
The purpose of this study is to determine the safety and efficacy of VSJ-110 compared to placebo in the treatment of dry eye.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: Vanda Investigational Site, Andover, Massachusetts
Conditions: Dry Eye
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A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Ulcerative Colitis, Crohn's Disease
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Ultrasound Therapy In Cardiac Amyloidosis
NCT04667494
Recruiting
This is a prospective pilot clinical study of subjects with cardiac amyloidosis and control subjects without amyloidosis where we plan to evaluate changes in myocardial blood flow, systolic and diastolic function before and after sonotherapy.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/05/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Amyloidosis Cardiac
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ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma
NCT04634357
Recruiting
Open-label, dose escalation, multi-center, Phase I/II clinical trial to assess the safety/tolerability and determine the recommended Phase II Dose (RP2D) of ET140203 T-cells in pediatric subjects who are AFP-positive/HLA-A2-positive and have relapsed/refractory HB, HCN-NOS, or HCC.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
03/05/2024
Locations: Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts
Conditions: Hepatoblastoma, Hepatocellular Carcinoma (HCC), Liver Neoplasms, Metastatic Liver Cancer, Liver Cancer, HEMNOS
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Multimodal, Task-Aware Movement Assessment and Control Using Functional Electrical Stimulation
NCT06301542
Recruiting
The study aims to investigate the relationship between post-stroke adults' movement patterns and disability levels. Utilizing the functional electrical stimulation (FES) system for individualized dorsiflexor and plantar flexor assistance during gait cycles. The investigators will analyze the cycles with and without the FES system. Initially, the context-aware motion assessment and neuroprosthetic control in a clinic will transition to in-home settings as the study progresses, broadening its appl... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Post-stroke
Register for Updates