Massachusetts is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Tolerability of 532 nm Laser Treatment of Port Wine Stains
NCT05841628
Recruiting
The goal of this study is to learn about treatment of port wine birthmarks treated with an FDA-approved 532 nm laser. The main questions it aims to answer are: * How well are the treatments tolerated? * Are there differences in tolerability of the treatment when a single high fluence laser pulse is used (the standard treatment) versus using multiple low fluence pulses? * Are there differences in results when using a single high fluence pulse versus multiple low fluence pulses? type of study:... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/11/2024
Locations: Wellman Center for Photomedicine, Harvard Medical School, Boston, Massachusetts
Conditions: Port-Wine Stain
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OCT Vibrography for Biomechanical Properties of Tissues
NCT05759780
Recruiting
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cornea, Skin Diseases, Gingival Diseases
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Screening Trial for Pain Relief in Schwannomatosis (STARFISH)
NCT05684692
Recruiting
This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple experimental therapies simultaneously in participants with moderate-to-severe pain due to schwannomatosis (SWN). This Master Study is being conducted as a platform that may allow participants with pain associated with schwannomatosis to receive a novel intervention throughout this study. Embedded within the Master Study are individual dr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Schwannomatosis, Schwannomas, Pain, Chronic
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Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia
NCT05343598
Recruiting
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study how hallucinations work in schizophrenia. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study the investigators will be stimulating the brain to learn more about how TMS might improve these symptoms of schizophrenia.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/11/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Schizophrenia, Schizo Affective Disorder
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Intermittent Fasting for NAFLD in Adults
NCT04899102
Recruiting
NAFLD is a growing threat to public health. Currently, there is a significant need for highly effective treatments for NAFLD. Non-obese NAFLD (BMI\<30kg/m2) is an increasingly recognized condition, sometimes described as "lean NAFLD". Intermittent Fasting (IF) may be uniquely beneficial in non-obese NAFLD. The purpose of this study is to identify non-pharmacologic, lifestyle-based methods of NAFLD treatment within non-obese adults.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Fatty Liver, Intermittent Fasting, Fatty Liver, Nonalcoholic, Non-Alcoholic Fatty Liver Disease, Liver Fat
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MBG453 in Lower Risk MDS
NCT04823624
Recruiting
This research study is assessing the efficacy of MBG-453, a humanized monoclonal antibody, in treating myelodysplastic syndromes (MDS). The name of the study drug involved in this study is MBG453.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Myelodysplastic Syndromes
Register for Updates
Calcitriol Monotherapy for X-Linked Hypophosphatemia
NCT03748966
Recruiting
Children and adults with XLH recruited will be treated with calcitriol alone (without phosphate supplementation) for one year, during which the calcitriol dose will be escalated during the first 3 months of therapy. The investigators hypothesize that treatment of adults and children with XLH alone will improve serum phosphate levels and skeletal mineralization without causing an increase in kidney calcifications. The study will also examine if calcitriol therapy will improve growth in children.
Gender:
ALL
Ages:
Between 3 years and 70 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: X-linked Hypophosphatemia, Hypophosphatemic Rickets, Hypophosphatemic Rickets, X-Linked Dominant
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A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
NCT02118922
Recruiting
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
03/11/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
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Speech Treatment for Minimally Verbal Children With ASD and CAS
NCT05066178
Recruiting
Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech.
Gender:
ALL
Ages:
Between 5 years and 18 years
Trial Updated:
03/10/2024
Locations: MGH Institute of Health Professions, Boston, Massachusetts
Conditions: Developmental Verbal Dyspraxia, Autism Spectrum Disorder
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MRI Guided Prostate Biopsy
NCT06302595
Recruiting
This study aims to assess the feasibility of magnetic resonance (MR) guided prostate biopsy using a needle holder frame. This frame is used to help position the needle used for the biopsy. The feasibility in this study is defined as whether the needle holder frame enables accurate tissue sampling from a suspicious region in the prostate found on an MR image. If it does, a biopsy can be carried out with the needle holder frame safely in a clinical routine. The study will be conducted during a rou... Read More
Gender:
MALE
Ages:
30 years and above
Trial Updated:
03/08/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Suspected Prostate Cancer
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Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy
NCT06300450
Recruiting
This single-center, 400-patient, randomized controlled trial assesses the impact of a patient- and provider-facing EPIC Best Practice Advisory (BPA; alert-based computerized decision support tool) to increase guideline-directed utilization of statin and statin-alternative oral LDL-C lowering therapies in patients with PAD who are not being prescribed LDL-C-lowering therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Peripheral Artery Disease, Peripheral Vascular Diseases, Dyslipidemias
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Emergency Care at Home
NCT06299774
Recruiting
This study will assess the efficacy of receiving emergency care at home versus in the brick-and-mortar emergency department.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Emergency Medical Services, Emergency Department Visits
Register for Updates