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Massachusetts Paid Clinical Trials
A listing of 3378 clinical trials in Massachusetts actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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Clinical Trial Phase
Massachusetts is currently home to 3378 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Featured Trial
Major Depressive Disorder Clinical Study
Recruiting
Is depression weighing you down? Local major depressive disorder clinical studies are now enrolling participants in the area. Participating in research studies helps contribute to the advancement of future medicine and treatment options. There is no obligation to take part and health insurance is not required.
Conditions:
Major Depressive Disorder
Major Depression
Major Depressive Episode
Major Depressive Disorder (MDD)
Major Depressive Disorders
Featured Trial
Hyperacusis Activities Treatment-Online Study
Recruiting
Are you experiencing hyperacusis? If so, we are recruiting adults with hyperacusis to complete a clinical trial supported by the National Institutes of Health. The study involves participating in a remote counseling program and sound therapy trial for hyperacusis, Hyperacusis Activities Treatment-Online.
Conditions:
Hyperacusis
Tinnitus
Hearing Loss
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices
Recruiting
The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with complex abdominal aneurysms, aortoiliac aneurysms, thoracoabdominal aneurysms and aortic arch aneurysms who (1) have anatomy not suitable for endovascular repair using grafts currently marketed in the United States,(2) are deemed unsafe to wait the required time necessary for... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/11/2023
Locations: UMass Memorial Health Care - University Campus, Worcester, Massachusetts
Conditions: Complex Aortic Aneurysms, Thoracoabdominal Aneurysms, Pararenal Aneurysms, Juxtarenal Aneurysms, Marfan Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome, Aortic Arch Aneurysm
Collection of Blood and/or Bone Marrow for Investigation and Characterization of Normal and Abnormal Cell Growth
Recruiting
The collection of Blood and/or Bone Marrow from patients with blood disorders, blood cell malignancies and associated conditions will serve as a convenient and comprehensive source of tissue to give us further information about the differences between normal blood cells and blood cells of affected individuals. This will be an invaluable asset for understanding the biology of blood disorders. The collected samples will be used by investigators for studies including immunology, molecular biology a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/11/2023
Locations: University of Massachusetts Medical School, Worcester, Massachusetts
Conditions: Leukemia
Influences of Female Sex and Reproductive Hormones on Physiological Aspects of Heat Acclimation
Recruiting
Women are often understudied in thermal physiology research, leaving recommendations for Soldier safety and performance in hot conditions based largely on data collected in men. Female sex hormones estradiol and progesterone clearly have non-reproductive physiological effects, including influences on thermoregulatory and cardiovascular function. However, mechanisms of differing physiological adaptations to repeated heat exposure (i.e., heat acclimation) as a function of reproductive hormone stat... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
05/10/2023
Locations: U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts
Conditions: Heat Stress, Exertional
Pilot Randomized Controlled Study of the Impact of MedRhythms' MR-010 in Acute Stroke
Recruiting
The purpose of this clinical pilot study is to evaluate the effects of the MR-010 on tolerability, biomechanics and walking speed in the acute stroke care setting in addition to its impact on length of stay.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/10/2023
Locations: UMass Chan Medical School, Worcester, Massachusetts
Conditions: Stroke, Acute
A Phase IV, Open-Label, Randomized, Active-controlled, Single-Center Study of ZYNRELEF® for Postoperative Analgesia After Laparoscopic Sleeve Gastrectomy
Recruiting
Approximately 120 subjects will be randomized into 1 of the following 2 treatment groups in a 1:1 ratio:
Group 1: ZYNRELEF® up to 200 mg/ 6mg ( 7ml vial) via instillation at all incision sites in addition to 30 ml of 0.5% Ropivacaine + 10mg dexamethasone. Postoperatively, intermittent IV acetaminophen will be administered as per need till discharge.
Group 2: 30 ml of 0.5% Ropivacaine and 10mg dexamethasone into all surgical sites and intermittent IV acetaminophen as per need till discharge.
P... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/09/2023
Locations: Holyoke Medical Center, Holyoke, Massachusetts
Conditions: Post Operative Pain, Acute, Bariatric Surgery Candidate, Postoperative Pain, Postoperative Opioid Use in Bariatric Surgery
Sirtuin-NAD Activator in Alzheimer's Disease
Recruiting
The primary objectives are to:
To determine whether MIB-626, after its daily oral administration, penetrates the blood-brain barrier in humans by measuring the cerebrospinal fluid (CSF) concentrations of MIB-626 and its key metabolites, nicotinamide (NAM), NR, 2-PY, and MeNAM at baseline and on day 90 at steady state.
To evaluate whether oral MIB-626 administration engages the sirtuin-NAD pathway by determining the abundance of NAD (a SIRT1 substrate) in the brain using ultra-high field 7T magn... Read More
Gender:
All
Ages:
Between 55 years and 85 years
Trial Updated:
05/09/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Alzheimer's Disease (Incl Subtypes), Dementia
Intervention For AYAS With Cancer Risk Syndromes
Recruiting
This research is being done because there is a need to improve cancer risk communication and decision-making among adolescents and young adults. In this study, the investigators are looking at whether using a chatbot and online portal for cancer risk information helps improve communication and decision-making.
Over 70,000 adolescents and young adults (AYAs) are diagnosed with cancer in the U.S. every year and up to 10% have genetic changes (or, mutations) that put them at a higher risk of devel... Read More
Gender:
All
Ages:
Between 12 years and 24 years
Trial Updated:
05/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Cancer Risk Syndrome
EndoBarrier System Pivotal Trial(Rev E v2)
Recruiting
A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the EndoBarrier System for Glycemic Improvement in Patients with Inadequately Controlled Type 2 Diabetes and Obesity, the STEP-1 Study.
A multi-center, double-blinded, randomized, sham-controlled trial to evaluate the safety and effectiveness of the EndoBarrier System plus moderate intensity lifestyle and dietary counseling compliant with 2019 ADA Standard of Care as compared to a sham control receiving moderate intensity... Read More
Gender:
All
Ages:
Between 30 years and 65 years
Trial Updated:
05/09/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Diabetes type2, Obesity
Family-centered Mental Health Promotion Intervention
Recruiting
Goal: The long-term goal of the proposed research program is to test the effectiveness of a preventative behavioral intervention and to scale it up for use with broader immigrant populations to reduce stress and mental health disorders.
Intervention: This study plan to adapt the World Health Organization developed Problem Management Plus (PMP), an evidence based, multi-component, behavioral intervention including breathing, problem solving, behavioral activation, and social support for immigran... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: University of Massachusetts Amherst, Amherst, Massachusetts
HOPE in Action Trial of HIV+ Deceased Donor Liver Transplants for HIV+ Recipients
Recruiting
The primary objective of this study is to determine if an HIV-infected donor liver (HIVD+) transplant is safe with regards to major transplant-related and HIV-related complications
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hiv
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
Recruiting
To goal of this clinical trial is to quantify the dose-response effects of aerobic exercise training compared to attention control on chemotherapy relative dose intensity in colon cancer survivors.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/05/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Colonic Neoplasms
Psychosis TMS Study
Recruiting
The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
05/04/2023
Locations: Martinos Center for Biomedical Imaging, Charlestown, Massachusetts
Conditions: Psychosis