Massachusetts is currently home to 3147 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Genetic Basis of Mitral Valve Prolapse
NCT01719211
Recruiting
The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsibl... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/07/2023
Locations: Mass General Hospital, Boston, Massachusetts
Conditions: Mitral Valve Prolapse
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Identification of Genetic Causes of Calcific Aortic Valve Disease
NCT04149600
Recruiting
This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.
Gender:
ALL
Ages:
20 years and above
Trial Updated:
11/06/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
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Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
NCT00595491
Recruiting
Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation. This work is designed to identify airway factors that are responsible for recruiting cells and associate their airway presence with atopy and asthma.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/03/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Asthma
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Sensor-based Characterization of Depression
NCT04370002
Recruiting
This is a longitudinal study where individual with Major Depressive Disorder (MDD) will be monitored for 12 weeks. The study aims to develop an objective, sensor-based, algorithm able to detect the presence of depression as well as predict treatment response. Measurement-based treatment is considered optimal and the development of a valid passive, objective, behavioral and biological assessment of depressive symptoms that does not rely on clinician interviews will improve monitoring and ultimate... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/02/2023
Locations: Depression Clinical Research Program, Boston, Massachusetts
Conditions: Unipolar Depression
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Safety and Efficacy Evaluation of the Mosaic Ultra Device
NCT06117293
Recruiting
Evaluate the Safety and Efficacy of the Mosaic Ultra 1550nm system for the treatment of skin tone and texture, facial rejuvenation, photoaging, wrinkles, scars, stretch marks, acne vulgaris and hair loss.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/01/2023
Locations: Lutronic, Billerica, Massachusetts
Conditions: Skin Texture Disorder, Photoaging, Wrinkle, Scar, Stretch Mark, Acne Vulgaris, Hair Loss
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Effects of MIB-626 With and Without A High-Intensity Multi-Dimensional Exercise Training Program
NCT05878119
Recruiting
A single-center, randomized, placebo-controlled study in community dwelling, healthy, regularly exercising, highly physically fit men and women, 19 to 40 years. Eligible participants will be randomized to receive either 1000 mg NMN or placebo twice daily for 10 weeks.
Gender:
ALL
Ages:
Between 19 years and 40 years
Trial Updated:
11/01/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Healthy
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Lenvatinib in Locally Advanced Invasive Thyroid Cancer
NCT04321954
Recruiting
This research is being done to evaluate the safety and efficacy of neoadjuvant lenvatinib on surgical outcomes of patients with invasive extrathyroidal differentiated thyroid cancer (DTC). This research study involves a study drug called lenvatinib
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Differentiated Thyroid Cancer, Advanced Cancer
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A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn
NCT01873131
Recruiting
The purpose of this study is to find out if pulsed dye laser treatment or timolol maleate 0.5% gel can help infants who have a hemangioma. The investigators also want to find out if pulsed dye laser treatment and timolol maleate 0.5% gel are safe to use without causing too many side effects. Hemangioma is a common type of birthmark. These birthmarks happen when many new blood vessels grow in a specific area on the skin. Blood vessels are tiny tubes that carry blood through the body. No one know... Read More
Gender:
ALL
Ages:
3 months and below
Trial Updated:
11/01/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hemangioma
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Stroke Motor Rehabilitation and Recovery Study
NCT03485040
Recruiting
SMaHRT (Stroke Motor reHabiliation and Recovery sTudy) is a longitudinal study aimed at understanding the natural history of upper extremity motor recovery after ischemic and hemorrhagic stroke.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
10/29/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Stroke, Ischemic
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COmbination Therapy With Baloxavir and Oseltamivir 1 for Hospitalized Patients With Influenza (The COMBO Trial 1)
NCT04327791
Recruiting
This is a randomized, double-blind, placebo-controlled Phase 2-like, investigator-directed trial of hospitalized patients with laboratory confirmed influenza. Eligible and consented patients will be randomly assigned, in a 1:1 ratio, to one of two groups: Group 1, the combination treatment group (oseltamivir and baloxavir); Group 2, the standard treatment group (oseltamivir and placebo).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/27/2023
Locations: Baystate Medical Center, Springfield, Massachusetts
Conditions: Influenza
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Clinical Study to Evaluate Different Energy-based Devices for Aesthetic Treatments.
NCT06111482
Recruiting
The goal of the energy-based devices used in this study is to evaluate their safety and performance to treat unwanted dermatologic conditions.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/26/2023
Locations: Cynosure, Westford, Massachusetts
Conditions: Dermatologic Conditions
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An Ethical Approach to Detecting Covert Consciousness
NCT05010265
Recruiting
This study aims to develop an ethical approach to developing and deploying novel neurotechnologies to aid in the detection of consciousness and prediction of recovery after brain injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/26/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Disorder of Consciousness
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