Massachusetts is currently home to 3147 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MED3000 Topical Gel for On-Demand Treatment of Post-Radical Prostatectomy Erectile Dysfunction
NCT05673005
Recruiting
The investigators are doing this research to evaluate the efficacy and safety of topical MED3000 therapy in men with persistent erectile dysfunction 1.5 to 4 years following radical prostatectomy surgery.
Gender:
ALL
Ages:
Between 40 years and 70 years
Trial Updated:
10/25/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Erectile Dysfunction Following Radical Prostatectomy
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INF108F in Infants With Food Protein Induced Proctocolitis
NCT05793112
Recruiting
Single-center, randomized, double-blind, placebo-controlled trail evaluating INF108F in breastfed infants with FPIAP
Gender:
ALL
Ages:
Between 1 day and 90 days
Trial Updated:
10/24/2023
Locations: Newton Wellesley Hospital, Newton, Massachusetts
Conditions: Infant Development, Gut Microbiome, Food Protein Induced Allergic Proctocolitis
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A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB
NCT05183646
Recruiting
DMX-200 (repagermanium) is a C-C chemokine receptor type 2 (CCR2) inhibitor that, when administered concurrently with an ARB, is designed to inhibit recruitment of monocytes implicated in the inflammatory chemokine environment of chronic disease. The purpose of this pivotal randomized double-blind study is to investigate the efficacy and safety of DMX-200 120 mg twice daily (BID) compared with placebo over a treatment period of 104 weeks in adult patients with FSGS who are being treated with an... Read More
Gender:
ALL
Ages:
Between 12 years and 80 years
Trial Updated:
10/24/2023
Locations: ACTION3 Investigational Site 21, Springfield, Massachusetts
Conditions: FSGS
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Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
NCT05103566
Recruiting
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage (SAH) subjects in a neurocritical care setting. 25 patients will be enrolled, all treated with an active device. The primary efficacy outcomes are reduced aneurysm rupture rate, reduced seizure and seizure-spectrum activity, minimized hemorrhage grades, and increased survi... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/24/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Subarachnoid Hemorrhage, Aneurysmal
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Triage Survey for Neurology Research Eligibility
NCT06104852
Recruiting
TRIAGE-Neuro is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored neurology clinical trials.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Copley Clinical, Boston, Massachusetts
Conditions: Alzheimer Disease
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A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest
NCT05899361
Recruiting
This research study is a pilot clinical trial, which hypothesizes that the combination of electromagnetic tracking in conjunction with laparoscope imaging and ultrasound probe imaging will aid in reducing the complexity of both laparoscopic lymphadenectomy and/or organ removal in patients with a confirmed diagnosis of cancer in urologic regions of interest (Bladder, Prostate, Testicular, Kidney, Urethral, and Penis), by resulting in better visualization and more accurate localization of certain... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Urologic Cancer, Urologic Neoplasms, Bladder Cancer, Prostate Cancer, Testicular Cancer, Kidney Cancer, Urethral Cancer, Penile Cancer
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Mucolipidosis Type IV Natural History Study
NCT05782387
Recruiting
The primary objectives of the study are: to describe the characteristics of the current international MLIV population; to define the median age at which patients with MLIV achieve or lose developmental milestones; to define the natural history of MLIV for the Gross Motor Function Classification System (GMFCS) (Morris and Bartlett, 2004) and the MLIV specific scale and test the validity of retrospectively applying these scales to medical record data; to define the rate of visual decline in patien... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/23/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Mucolipidosis Type IV
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Urologic Lymphadenectomy in AMIGO
NCT05132283
Recruiting
This research study involves the use of two navigation systems, the 3D Slicer-based navigation system, and the Siemens Monaco systems, to simplify the complexity of image-guided lymphadenectomy procedures (surgery to remove one or more lymph nodes) in patients with urological cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Urologic Cancer, Lymph Node Metastasis
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Epidermal Skin Grafts to Improve Healing In Radiation Wounds
NCT04560803
Recruiting
Patients undergoing radiation for the treatment of malignancies may suffer from side effects to the skin in the form of radiation dermatitis. This can lead to local wound formation with poor healing. Treatment options for the resulting wound can range from watchful waiting to more aggressive debridement and secondary grafting. Epidermal grafting is a technique in which autologous epidermis is used to cover wounds that are larger than the donor site. Previous studies have demonstrated that this... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/20/2023
Locations: Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts
Conditions: Radiation Dermatitis
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A Study of HB0045 Injection in Patients With Advanced Solid Tumors
NCT06056323
Recruiting
This is a phase I/II, open-label, multicenter study . During the study, subjects will be evaluated for safety, toxicity, tolerability, PK/PD, immunogenicity, biomarkers, and antitumor activity of HB0045. The phase I study will enroll up to 54 subjects with advanced solid tumors who have progressed on or after standard of care therapy and for whom there is no further treatment available that in the judgement of the patient's physician would be beneficial. One cycle is defined as 21 days.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Solid Tumor, Adult
Register for Updates
Triage Survey for Psychiatry Research Eligibility
NCT05800925
Recruiting
TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: Copley Clinical, Boston, Massachusetts
Conditions: Major Depressive Disorder, Borderline Personality Disorder, Generalized Anxiety Disorder
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IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures
NCT04842266
Recruiting
The aim of this project is to assess the effectiveness of the IlluminOss pelvic implants in patients with pelvic metastatic disease presenting with pain, risk of pathologic fracture, non-displaced or minimally displaced pathologic fracture of the pelvis, and geriatric patients with pelvic fragility fractures. Results from this study will be used to confirm preliminary clinically and possibly statistically significant reductions in pain and improvements in function among these patients.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/19/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cancer Metastatic, Trauma, Pathologic Fracture
Register for Updates