Massachusetts is currently home to 3366 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging
NCT03265535
Recruiting
We propose a single-scan two-injection myocardial perfusion imaging protocol using ammonia. Subjects will undergo single-scan two-injection imaging as well as regular stress single-scan single-injection protocol and the myocardial blood flow of both techniques will be compared.
Gender:
All
Ages:
Between 30 years and 75 years
Trial Updated:
04/11/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Coronary Artery Disease, Myocardial Ischemia
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Impact of Diet on the Gut-Muscle Axis in Older Adults
NCT05549622
Recruiting
Muscle health declines during aging. One factor that may impact muscle health is the community of bacteria that live in our intestines, but studies aimed at improving muscle health by targeting the gut in older adults are sparse. The primary goal of this study is to use a diet that is enriched in soluble fiber, which is exclusively utilized by gut bacteria to make substances that can impact muscle health, to improve muscle-related measures in older adults.
Gender:
All
Ages:
65 years and above
Trial Updated:
04/10/2023
Locations: Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
Conditions: Sarcopenia, Dietary Exposure, Microbial Colonization
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Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients
NCT04773457
Recruiting
Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.
Gender:
All
Ages:
Between 12 months and 19 years
Trial Updated:
04/10/2023
Locations: Boston Children's Hopsital, Boston, Massachusetts
Conditions: Surgical Site Infection
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ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma
NCT04480502
Recruiting
This is a multicenter open-label, randomized, non-comparative, parallel cohort pivotal study of treatment with envafolimab (cohort A and C) or envafolimab combined with ipilimumab (cohort B and D) in patients with locally advanced, unresectable or metastatic undifferentiated pleomorphic sarcoma (UPS)/myxofibrosarcoma (MFS) who have progressed on one or two lines of chemotherapy.
Gender:
All
Ages:
12 years and above
Trial Updated:
04/10/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
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Identifying Genetic Causes of IC/BPS
NCT00389142
Recruiting
Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS), or chronic pelvic pain syndrome(CPPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another. In this study, we are collecting genetic material and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS/CPPS. We are enrolling families... Read More
Gender:
All
Ages:
Between 1 week and 100 years
Trial Updated:
04/09/2023
Locations: Boston Children's Hospital (BCH), Boston, Massachusetts
Conditions: Interstitial Cystitis, Chronic Pelvic Pain Syndrome, Bladder Pain Syndrome
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Estrogen Administration for the Treatment of NASH in Postmenopausal Women
NCT04833140
Recruiting
Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic in the United States. Despite this, the treatment options remain limited. Preclinical and preliminary clinical data suggest that estrogen deficiency plays an important role in the pathology of steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Post-menopausal women are a growing population with particularly high risk of NASH due to their lack of estrogen. This study will exam... Read More
Gender:
Female
Ages:
Between 45 years and 70 years
Trial Updated:
04/07/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: NASH - Nonalcoholic Steatohepatitis
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Intervention to Improve HIV Self-care Among People Who Inject Drugs
NCT05819411
Recruiting
This study will implement a pilot randomized controlled trial (RCT, N=70) to refine and assess the feasibility and acceptability of an emotion regulation and communication skills intervention designed to improve engagement in HIV-care among substance using HIV+ PWID sub-optimally engaged in HIV care.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: Fenway Community Health, Boston, Massachusetts
Conditions: Hiv, Substance Use Disorders
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RAE (Realize, Analyze, Engage)
NCT05227339
Recruiting
The proposed study will evaluate the detection of digital biomarkers of stress, and drug craving in a population of individuals undergoing treatment for substance use disorder
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: University of Massachusetts Chan Medical School, Worcester, Massachusetts
Conditions: Substance Use Disorders, Treatment Adherence and Compliance
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Remote Monitoring in Progressive Supranuclear Palsy (PSP)
NCT04753320
Recruiting
This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of approximately one year. Participants will perform supervised remote assessments monthly and in-person assessments approximately every 6 months.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
04/05/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Progressive Supranuclear Palsy
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The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study
NCT04943172
Recruiting
A prospective, non blinded, single arm, multicenter study designed to assess the safety and effectiveness of the bioprosthetic, VenoValve, which is surgically implanted into the deep venous system for treatment of patients with deep venous valvular insufficiency ( C4b-C6 patients).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Deep Venous Insufficiency (Diagnosis)
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Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension
NCT04500574
Recruiting
In this research study, we will assess the safety, tolerability, comfort, and feasibility of lowering intraocular pressure using a novel Contact Lens Drug Delivery System with latanoprost. Latanoprost is a well-studied medication and has been used to treat glaucoma for decades. Currently, latanoprost is FDA-approved to be administered to patients as eye drops, but using eye drops has challenges (having to remember to take the drop, getting the drop in the eye). This clinical trial is being done... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/04/2023
Locations: Massachusetts Eye and Ear, Boston, Massachusetts
Conditions: Glaucoma, Ocular Hypertension
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Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
NCT04136002
Recruiting
The ECLIPSE (Evaluation of the ctDNA LUNAR test in an Average Patient Screening Episode) study is a prospective, observational multi-site study without randomization. The primary objective of the study is to evaluate the performance characteristics of a blood-based ctDNA LUNAR-2 test to detect colorectal cancer in a screen-relevant, average risk population.
Gender:
All
Ages:
Between 45 years and 84 years
Trial Updated:
04/04/2023
Locations: Digestive Health Specialists, Chelmsford, Massachusetts
Conditions: Colorectal Cancer
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