Massachusetts is currently home to 3213 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Central and Peripheral Effects of Cognitive Behavioral Therapy on Brain-Gut Axis Signaling in Gastroparetic Patients
NCT03531450
Recruiting
This is a single-center pilot study to be conducted at Massachusetts General Hospital. The purpose of this study is to examine the non-pharmacological impact of Cognitive Behavioral Therapy (CBT) on gastroparesis symptoms and other clinical co-comorbidities such as pain, depression, anxiety, and catastrophizing. CBT trial patients will undergo careful phenotyping pre- and post- intervention with brain MRI, autonomic function test (AFT), gastric emptying scintigraphy (GES), and nutrient drink tes... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/24/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Gastroparesis
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Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
NCT02792270
Recruiting
This study is being conducted to decrease the rate of surgical wound complications. The investigators are studying the effects that caloric restriction has on decreasing the rate of surgical wound complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: Massachusetts general Hospital, Boston, Massachusetts
Conditions: Tumor Surgery
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Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care
NCT05726331
Recruiting
This feasibility project aims to evaluate the effectiveness of chiropractic care combined with Tai Chi (TC) training to reduce pain and disability in adults with chronic non-specific neck pain (CNNP).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/18/2024
Locations: Osher Clinical Center at Brigham and Women's Hospital, Chestnut Hill, Massachusetts
Conditions: Neck Pain, Chronic Pain
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Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
NCT06206265
Recruiting
Participants with IBS (all subtypes) and with no exclusionary comorbid psychiatric or medical disorders will be enrolled in the study. This study will involve a randomized waitlist control design to investigate the rapid and sustained effects of TRP-8802 following two experimental sessions in which an oral dose of TRP-8802 is administered to participants with IBS. The study will include clinician and participant ratings of depression and anxiety pre- and post-drug-session, monitor and participa... Read More
Gender:
ALL
Ages:
Between 21 years and 64 years
Trial Updated:
01/17/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Irritable Bowel Syndrome
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Study of Eblasakimab in Male or Female Moderate-to-Severe Atopic Dermatitis Patients Previously Treated With Dupilumab
NCT05694884
Recruiting
Multicenter, randomized, double-blind, placebo-controlled, parallel arm clinical study designed to evaluate the efficacy and safety of eblasakimab in participants with moderate-to-severe atopic dermatitis (AD) previously treated with dupilumab.The study consists of a 16-week treatment period and an 8-week follow-up period up to Week 24. Eligible participants will be randomized into one of the 2 treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2024
Locations: ASLAN Investigative Site, Quincy, Massachusetts
Conditions: Atopic Dermatitis
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A Mindful Community for People With ALS and Their Primary Caregivers
NCT05595850
Recruiting
The psychological impact of ALS on patients and caregivers is high, significantly affecting their quality of life (QOL). Despite this impact, there is not much research about psychological interventions that could reduce psychological distress and improve QOL. The efficacy of mindfulness-based treatments for the improvement of QOL was previously demonstrated by the investigator's group. Despite preliminary positive results, treatment efficacy tends to weaken over time. The investigators believe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2024
Locations: Harvard University, Cambridge, Massachusetts
Conditions: Amyotrophic Lateral Sclerosis, Caregiver Burden
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Diagnostic Performance of Small RNA Blood Test in Patients Undergoing Follow-up Imaging After Positive Low Dose CT Screening for Cancer of the Lung
NCT05987189
Recruiting
2,000 individuals, aged 50-80 who have received a lung-RADS category 3 or 4 result on a LDCT screening study and who are scheduled for follow-up diagnostic imaging study, biopsy, clinical consultation or surgical appointment at one of the participating hospitals.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
01/12/2024
Locations: Mass General Brigham, Boston, Massachusetts
Conditions: Lung Cancer
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Ultrahypofractionation and Normal Tissue Toxicity
NCT05912231
Recruiting
This research is being done to see if proton beam radiation therapy (PBT) results in fewer changes to a participant's heart measured with MRI-imaging than conventional or "photon" radiation therapy (XRT) for participants with non-metastatic left sided breast cancer. The names of the two study groups in this research study are: * Proton Radiation Therapy (PBT) * Conventional or "Photon" Radiation Therapy (XRT)
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Breast Cancer, Breast Cancer Female, Breast Cancer Stage II, Breast Cancer Stage III, Myocardial Fibrosis
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Losartan in Prevention of Radiation-Induced Heart Failure
NCT05607017
Recruiting
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer. The interventions involved in this study are: * Losartan * Radiation Therapy (standard of care)
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/11/2024
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Breast Cancer, Myocardial Fibrosis, Radiation-Induced Fibrosis
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ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators
NCT01590862
Recruiting
We propose to study approach/avoidance behavior as measured by the Approach Avoidance task in 20 epilepsy patients undergoing implementation of depth electrodes for seizure monitoring in the Epilepsy Monitoring Unit at MGH. We will also study the effects of VC/VS electrical stimulation on approach-avoidance conflict in 20 adult patients who have undergone DBS implantation for severe MDD and/or OCD. There are 100-200 patients in the world with DBS electrodes in the VC/VS, and our research team ca... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/10/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Obsessive Compulsive Disorder, Major Depressive Disorder, Epilepsy
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Using Microbial Genomics to Elucidate the Source of Central-line Associated Bloodstream Infections
NCT02271243
Recruiting
Central line-associated bloodstream infections (CLABSIs) are the most common healthcare-associated infection in children and are associated with morbidity and mortality. This study will attempt to identify the source of bloodstream infections (BSIs) in children with CLABSI because we hypothesize that many of the BSIs that are currently classified as CLABSIs are actually laboratory-confirmed bloodstream infections (LCBI) that may be a result of mucosal barrier injury (MBI), also known as MBI-LCBI... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/08/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Laboratory-confirmed Bloodstream Infection, Central Line-associated Bloodstream Infections, Mucosal Barrier Injury
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PRotein Optimization With eXercise to Improve MUscle Mass and Functional outcomeS
NCT05296096
Recruiting
The investigators have designed a 2-center, pilot feasibility, randomized controlled trial (PROXIMUS) to determine the feasibility and safety of a larger multi center, randomized open-label trial comparing high protein combined with individualized exercise vs. standard management during the acute phase of critical illness in children. The investigators aim to determine the impact of the intervention on preservation of muscle mass; and functional status at 1 month and 6 months after randomization... Read More
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
01/04/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Muscle Loss, Protein, Mobility, Pediatric ALL
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