Massachusetts is currently home to 3175 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Jump: MR Simulation For Radiation Therapy Master Protocol
NCT04545957
Recruiting
This is a master protocol for a prospective Phase I-II study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (MRI) simulation into the planning of radiation treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2023
Locations: Brigham and Women Hospital, Boston, Massachusetts
Conditions: Prostate Cancer, Recurrent Adenocarcinoma, Liver Cancer, Head and Neck Cancer
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Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)
NCT04321759
Recruiting
To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service cente... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/13/2023
Locations: Massachusetts Mental Health Center, Boston, Massachusetts
Conditions: Schizophrenia and Related Disorders
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Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial
NCT03868293
Recruiting
The aim of the proposed pilot study is to investigate patient tolerability and efficacy of moderate term, repeated exposure of Pulsed Low-Intensity Focused Ultrasound (PLIFUS) in patients with drug-resistant temporal lobe epilepsy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/09/2023
Locations: Brigham and women's Hospital, Boston, Massachusetts
Conditions: Drug Resistant Epilepsy
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Impact of Intensive Computerized Cognitive Training
NCT06130735
Recruiting
To investigate factors that predict cognitive enhancement following engagement in an intensive Computerized Cognitive Training Protocol.
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
11/08/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Acquired Brain Injury, Mild Cognitive Impairment, Mild Neurocognitive Disorder
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Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants
NCT05777512
Recruiting
The purpose of this study is to determine if postpyloric feedings effectively improve objective measures of pulmonary health in preterm infants with chronic lung disease when compared with nasogastric (NG) feedings. This research will (1) determine the optimal nutritional management to prevent a common and costly complication of prematurity, and (2) use a novel crossover design that examines outcomes of clinical endpoints alongside biomarkers.
Gender:
ALL
Ages:
Between 0 hours and 1 year
Trial Updated:
11/08/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Bronchopulmonary Dysplasia
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Implementation of a Consensus-Based Discharge Protocol for Preterm Infants With Lung Disease
NCT05285345
Recruiting
The researchers have worked to create consensus recommendations among national efforts to help with the transition and coordination of care for preterm infants with lung disease around discharge from the neonatal intensive care unit to home. This study looks to evaluate implementation of the recommendations at Boston Children's Hospital and referring NICU's (Beth Israel Deaconess Medical Center and Brigham and Women's Hospital). Specifically, the research team will be looking at follow-up rates,... Read More
Gender:
ALL
Ages:
Between 0 days and 1 year
Trial Updated:
11/08/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Bronchopulmonary Dysplasia
Register for Updates
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
NCT03059420
Recruiting
The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
Gender:
ALL
Ages:
1 day and above
Trial Updated:
11/08/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome, Duane Radial Ray Syndrome, Mobius Syndrome, Brown Syndrome, Marcus Gunn Syndrome, Strabismus Congenital, Horizontal Gaze Palsy, Horizontal Gaze Palsy With Progressive Scoliosis, Facial Palsy, Facial Paresis, Hereditary, Congenital, Third Nerve Palsy, Fourth Nerve Palsy, Sixth Nerve Palsy, Synkinesis, Ocular Motility Disorders, Levator-Medial Rectus Synkinesis, Athabaskan Brainstem Dysgenesis, Tongue Paralysis, Ninth Nerve Disorder, Fifth Nerve Palsy, Seventh Nerve Palsy, Eleventh Nerve Disorder, Twelfth Nerve Disorder, Vagus Nerve Paralysis, Moebius Sequence
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National Pregnancy Registry for Psychiatric Medications
NCT01246765
Recruiting
The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications such as antidepressants, ADHD medications, sedative hypnotics, and atypical antipsychotics that many people take during pregnancy to treat a wide range of mood, anxiety, executive function, or psychiatric disorders. The goal of this Registry is to gather information on the safety of these medications during pregnancy, as current data is limited.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/08/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pregnant Women, Psychotropic Drugs
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Genetic Basis of Mitral Valve Prolapse
NCT01719211
Recruiting
The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsibl... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/07/2023
Locations: Mass General Hospital, Boston, Massachusetts
Conditions: Mitral Valve Prolapse
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Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
NCT00595491
Recruiting
Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation. This work is designed to identify airway factors that are responsible for recruiting cells and associate their airway presence with atopy and asthma.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/03/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Asthma
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Sensor-based Characterization of Depression
NCT04370002
Recruiting
This is a longitudinal study where individual with Major Depressive Disorder (MDD) will be monitored for 12 weeks. The study aims to develop an objective, sensor-based, algorithm able to detect the presence of depression as well as predict treatment response. Measurement-based treatment is considered optimal and the development of a valid passive, objective, behavioral and biological assessment of depressive symptoms that does not rely on clinician interviews will improve monitoring and ultimate... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/02/2023
Locations: Depression Clinical Research Program, Boston, Massachusetts
Conditions: Unipolar Depression
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Safety and Efficacy Evaluation of the Mosaic Ultra Device
NCT06117293
Recruiting
Evaluate the Safety and Efficacy of the Mosaic Ultra 1550nm system for the treatment of skin tone and texture, facial rejuvenation, photoaging, wrinkles, scars, stretch marks, acne vulgaris and hair loss.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/01/2023
Locations: Lutronic, Billerica, Massachusetts
Conditions: Skin Texture Disorder, Photoaging, Wrinkle, Scar, Stretch Mark, Acne Vulgaris, Hair Loss
Register for Updates