Massachusetts is currently home to 3214 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PRotein Optimization With eXercise to Improve MUscle Mass and Functional outcomeS
NCT05296096
Recruiting
The investigators have designed a 2-center, pilot feasibility, randomized controlled trial (PROXIMUS) to determine the feasibility and safety of a larger multi center, randomized open-label trial comparing high protein combined with individualized exercise vs. standard management during the acute phase of critical illness in children. The investigators aim to determine the impact of the intervention on preservation of muscle mass; and functional status at 1 month and 6 months after randomization... Read More
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
01/04/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Muscle Loss, Protein, Mobility, Pediatric ALL
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Time-restricted Eating in Peri- and Postmenopausal Women
NCT06188598
Recruiting
The overall objective of the study is to examine the effect of an 8-hour time-restricted eating intervention on lipid levels and body composition in peri- and recently postmenopausal women with untreated dyslipidemia.
Gender:
FEMALE
Ages:
Between 40 years and 58 years
Trial Updated:
01/03/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Dyslipidemias, Obesity, Menopause
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Targeting Orexin to Treat Nicotine Dependence
NCT03999099
Recruiting
Tobacco smoking continues to be the primary cause of preventable mortality in the United States. Despite the availability of smoking cessation aids, the majority of those trying to quit smoking end up relapsing. Thus, there is a strong need to evaluate alternative treatment targets such as orexin antagonists, which have shown promise in preclinical models at reducing the motivational aspects of drug use.The current work will evaluate the influence of orexin antagonism on several factors impactin... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
01/03/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Nicotine Dependence
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Development of LabPatch-alcohol as a Noninvasive Skin Patch to Detect Blood Alcohol Concentrations
NCT03242161
Recruiting
This study is designed to test LabPatch-alcohol, a wearable, non-invasive biosensor Band-Aid like patch that is designed to detect real-time changes in interstitial alcohol concentrations in human subjects. The changes in interstitial alcohol concentrations will be compared to blood alcohol concentrations to determine the patch's validity against the gold standard.
Gender:
ALL
Ages:
Between 21 years and 50 years
Trial Updated:
01/03/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Alcohol Intoxication
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Electronic Cigarettes and Reactivity to Smoking Cues
NCT01782599
Recruiting
The purpose of this study is to determine whether electronic cigarettes can reduce reactivity to smoking-related cues.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
01/03/2024
Locations: Mclean Hospital Imaging Center, Belmont, Massachusetts
Conditions: Nicotine Dependence
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Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation
NCT04890613
Recruiting
This is an open-label, multi-center, phase 1b study designed to determine a tolerable dose of CX-5461 administered by IV infusion on Day 1 and Day 8 of a 28-day cycle in patients with selected solid tumours and associated mutations for future Phase II trials. The safety and tolerability of CX-5461, preliminary evidence of antitumor effect and the effect of CX-5461 on the Health-Related Quality of Life (HRQoL) will also be evaluated. The study will also evaluate the predictive value of mutational... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Advanced Solid Tumor
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Comparison of the Q-NRG+ Indirect Calorimetry Device Versus the V(Max) Encore Device in Mechanically Ventilated Children
NCT04482556
Recruiting
The overarching aim of this proposal is to examine the feasibility of the Q-NRG+ indirect calorimetry device and its agreement with (Vmax) Encore indirect calorimetry device in mechanically ventilated children. The overall hypothesis of this study is that the Q-NRG+ will provide minute-to-minute oxygen consumption (VO2) and carbon dioxide production (CO2) measurements that are in agreement with those obtained by the standard indirect calorimetry device currently used at our institution (Vmax Enc... Read More
Gender:
ALL
Ages:
Between 10 years and 18 years
Trial Updated:
12/31/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Calorimetry, Indirect, Oxygen Consumption, Metabolism, Mechanical Ventilation
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CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
NCT05143996
Recruiting
CLN-049-001 is a Phase 1, open-label, multicenter, first-in-human trial of CLN-049 in patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/22/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Relapsed/Refractory Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
Register for Updates
Conversational Agent Vaccine Promotion RCT
NCT04884750
Recruiting
The objective of this study is to assess the use of and satisfaction with the ECA intervention over a 12-month period, its ability to increase SARS-CoV-2 and influenza vaccination in the BMATP community, and the comparative effectiveness of proactive engagement strategies and cultural tailoring on these factors. The Investigators will assess app use and satisfaction among these participants, along with self-reported vaccination attitudes and behavior, at 6 months and 12 months. During this time... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/21/2023
Locations: Northeastern University, Boston, Massachusetts
Conditions: Pandemics
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A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
NCT04775485
Recruiting
FIREFLY-1 is an ongoing, Phase 2, multi center, open-label study to evaluate the safety and efficacy of oral pan-RAF inhibitor DAY101 in pediatric, adolescent, and young adult patients with recurrent or progressive low-grade glioma or an advanced solid tumor harboring a known RAF alteration.
Gender:
ALL
Ages:
Between 6 months and 25 years
Trial Updated:
12/21/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Low-grade Glioma, Advanced Solid Tumor
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Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers
NCT05157880
Recruiting
The purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress in at risk dyads admitted to a Neuroscience Intensive Care Unit with an acute brain injury. Through this study, we seek to solve the unmet need of preventing chronic emotional distress in Neuroscience Intensive Care Unit (NICU) dyads through a feasible, acceptable and credible program, and ideally improve the recovery... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2023
Locations: Massachusetts General Hospital (MGH), Boston, Massachusetts
Conditions: Acute Neurological Injury, Emotional Distress
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A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma
NCT03941379
Recruiting
The purpose of this observational research study is to follow participants who have been treated with either bel-sar or received alternate treatment (sham, standard of care therapy, etc.) while participating in a previous Aura Biosciences clinical research study to assess the long-term safety and effectiveness in these subjects. This study will collect information from procedures conducted as part of routine follow-up eye care and cancer care. Additionally, the registry will collect all adverse... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2023
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Choroidal Melanoma, Indeterminate Lesions of Eye
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