Massachusetts is currently home to 3175 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Human Epilepsy Genetics--Neuronal Migration Disorders Study
NCT00041600
Recruiting
The purpose of this study is to identify genes responsible for epilepsy, brain malformations and disorders of human cognition.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2023
Locations: Boston Children's Hospital, Walsh Laboratory, Boston, Massachusetts
Conditions: Epilepsy, Brain Malformation, Neuronal Migration Disorder, Cognition Disorder
Register for Updates
Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes
NCT04496479
Recruiting
This Phase 2a clinical trial is a dose escalation study of the safety, tolerability, and efficacy of hepatocyte transplantation into lymph nodes via endoscopic ultrasound among subjects with end-stage liver disease.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/19/2023
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: End Stage Liver Disease
Register for Updates
A Prospective Clinical Study to Assess the Clinical Utility of Turbidity in Patients Using In-Home Peritoneal Dialysis
NCT05285436
Recruiting
This study aims to determine if the CloudCath device can detect infections related to peritoneal dialysis (peritonitis) as fast or faster than the current standard methods used by patients and doctors to detect such infections.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/16/2023
Locations: Dialysis Center of Western Massachusetts Llc, Chicopee, Massachusetts
Conditions: End Stage Renal Disease, Peritoneal Dialysis-associated Peritonitis, Peritonitis
Register for Updates
The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients
NCT03270072
Recruiting
The objective of the study is to serve as a correlative study for patients enrolled on the RadCOMP trial (NCT02603341), a randomized phase III study of stage II and III breast cancer patients treated with either conventional photon radiation or proton beam radiation
Gender:
ALL
Ages:
21 years and above
Trial Updated:
09/15/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Breast Cancer Stage II, Breast Cancer Stage III
Register for Updates
Vaginal Microbiome and IVF Pregnancy Outcome
NCT05150639
Recruiting
The aim of this prospective, observational study is to investigate the prevalence of vaginal dysbiosis among women undergoing IVF procedures in the US. And to investigate the associations between the vaginal microbiome and the pregnancy outcome following IVF.
Gender:
FEMALE
Ages:
Between 18 years and 44 years
Trial Updated:
09/12/2023
Locations: Boston IVF The Waltham Center, Waltham, Massachusetts
Conditions: Vaginal Flora Imbalance
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Reducing Racial Disparities in Severe Maternal Morbidity
NCT04879797
Recruiting
There is a paucity of research examining the intersection of race, ethnicity, maternal safety bundles, doulas, and maternal outcomes in Black women at increased risk of severe maternal morbidity and mortality. The proposed mixed-methods study is the first systematic investigation of pregnancy complications and outcomes among Black women with whom maternal safety bundles are being implemented including racial disparities, hemorrhage, and hypertension. Additionally, through the analysis of seconda... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
09/12/2023
Locations: Tufts University, Boston, Massachusetts
Conditions: Maternal Death
Register for Updates
A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)
NCT05394064
Recruiting
This is a Phase 1/2 randomized, blinded, dose-escalation study to evaluate the safety and efficacy of intrathecal (IT) administration of SBT101, a recombinant adeno-associated virus serotype 9 (AAV9) containing a functional copy of the human adenosine triphosphate (ATP)-binding cassette transporter subfamily D member 1 (ABCD1; hABCD1) gene, in adult patients with adrenomyeloneuropathy (AMN) aged 18-65 years. Patients will receive a single dose of SBT101 via IT route (or an imitation procedure)... Read More
Gender:
MALE
Ages:
Between 18 years and 65 years
Trial Updated:
09/11/2023
Locations: University of Massachusetts Chan Medical School, Worcester, Massachusetts
Conditions: AMN, AMN Gene Mutation, X-ALD
Register for Updates
Health Effects of Substituting Sugary Beverages With Artificially-sweetened Beverages or Water
NCT04567108
Recruiting
Sugar-sweetened beverages (SSBs) contribute an alarming \~7% of calories in the US diet among adults, making SSBs the single largest source of added sugar. However, whether artificially sweetened beverages are a healthful alternative for reducing SSB intake among habitual SSB consumers is unknown. Therefore, the investigators will conduct a 4-arm randomized diet intervention trial to test the effects of substituting SSBs with calorie-free alternatives on body weight and health, among habitual SS... Read More
Gender:
ALL
Ages:
Between 20 years and 69 years
Trial Updated:
09/08/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Body Weight
Register for Updates
Addressing Anxiety in 2-3-Year-Olds: A Pilot Intervention Study
NCT04039243
Recruiting
The purpose of this study is to test the feasibility and efficacy of intervening with 2-year-old children with elevated temperamental Fear and/or Shyness or 3-year-old children with elevated anxiety and their parents, using a parent-child Cognitive Behavioral Therapy (CBT) protocol to reduce anxiety disorders and maintain reduced anxiety at one-year follow-up. Before the COVID-19 pandemic, study visits and treatment sessions were conducted in office. Now all visits and treatment sessions are con... Read More
Gender:
ALL
Ages:
Between 21 months and 47 months
Trial Updated:
09/06/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Anxiety Disorder of Childhood, Fear, Shyness
Register for Updates
Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension
NCT05884190
Recruiting
The investigators primary project goal is to improve clinical outcomes, including mental health outcomes, among postpartum at-risk women experiencing health disparities by increasing awareness, detection, and timely care of postpartum hypertension, mental health and cardiovascular complications. The investigators will accomplish this by comparing the effectiveness of two multi-component multi-level healthcare delivery models focused on early detection and control of postpartum hypertension and t... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: University of Massachusetts Memorial Health, Worcester, Massachusetts
Conditions: Postpartum Hypertension
Register for Updates
Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location
NCT05839899
Recruiting
Patients who seek medication abortion early in pregnancy may have an ultrasound that does not show a pregnancy in the uterus. This is known as a "pregnancy of unknown location". These patients most likely have a pregnancy in the uterus that is too early to be seen on ultrasound, but it is possible that the pregnancy is not seen inside the uterus because it is outside of the uterus, known as an ectopic pregnancy. Patients with ectopic pregnancies are at risk for serious complications, and the med... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/30/2023
Locations: Planned Parenthood League of Massachusetts, Boston, Massachusetts
Conditions: Abortion
Register for Updates
Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
NCT01196182
Recruiting
Congenital heart defects (CHD) are the most common major human birth malformation, affecting \~8 per 1,000 live births. CHD are associated with significant morbidity and mortality, and are second only to infectious diseases in contributing to the infant mortality rate. Current understanding of the etiology of pediatric cardiovascular disorders is limited. The Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) is a multi-center, prospective observational cohort study. Participants will b... Read More
Gender:
ALL
Ages:
99 years and below
Trial Updated:
08/29/2023
Locations: Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Defects
Register for Updates