Massachusetts is currently home to 3175 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
NCT04370587
Recruiting
This is a Phase 1/2a, open-label, study to evaluate the safety and preliminary efficacy of intratumoral T3011 given alone and in combination with intravenous pembrolizumab in partients with advanced or metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Melanoma, Solid Tumor, NSCLC, HNSCC, Sarcoma, Squamous Cell Carcinoma
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OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study
NCT05405374
Recruiting
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar interbody fusion (LIF) by means of an intra-patient control model.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
08/25/2023
Locations: New England Baptist Hospital, Boston, Massachusetts
Conditions: Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
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Word Learning in Deaf Children Using Eye-tracking and Behavioral Measures
NCT05993832
Recruiting
Mutual exclusivity is a word learning constraint in which the learner assumes that a given word refers to only one category of objects. In spoken languages, mutual exclusivity has been demonstrated in monolingual children as young as 17 months and cross-linguistically, while multilingual learners show an attenuated mutual exclusivity bias. Mutual exclusivity has not been robustly demonstrated in deaf children acquiring American Sign Language (ASL). Further, it is unclear if mutual exclusivity ap... Read More
Gender:
ALL
Ages:
Between 18 months and 60 months
Trial Updated:
08/24/2023
Locations: Boston University, Boston, Massachusetts
Conditions: Deafness
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Effects of Altered Auditory Feedback on Speech Fluency
NCT06011837
Recruiting
The purpose of the study is to use altered auditory vocal feedback to increase fluency in people who stutter and to examine changes in this effect over the course of a one month period occurring outside the laboratory setting.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/21/2023
Locations: Massachusetts Institute of Technology, Cambridge, Massachusetts
Conditions: Stuttering, Adult
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Dropless Pars Plana Vitrectomy Study
NCT05331664
Recruiting
To demonstrate that intraoperative use of subtenon triamcinolone acetonide at the time of surgery without postoperative eye drops is non-inferior to the regimen of postoperative eye drops following primary pars plana vitrectomy for retinal detachment.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/16/2023
Locations: Massachusetts Eye and Ear, Boston, Massachusetts
Conditions: Rhegmatogenous Retinal Detachment
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The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
NCT05258981
Recruiting
The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).
Gender:
ALL
Ages:
Between 24 years and 35 years
Trial Updated:
08/14/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease
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Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications
NCT04229368
Recruiting
Vitamin D status has been shown to have an effect on post-operative outcomes in total joint arthroplasty. The goal of this study is to determine if pre-operative supplementation and correction of Vitamin D deficiency can reduce postoperative complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Hip Arthropathy, Knee Arthropathy, Vitamin D Deficiency
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The Effects of a Virtual Yoga Program on Patients With Chronic Pain
NCT05211414
Recruiting
This research is being done to determine if remote yoga-based exercise can help reduce chronic pain. It will include three virtual research visits. This cohort study will include three remote research visits and an online questionnaire administration. In addition, participants will attend 8 weekly virtual yoga sessions with a daily 30-minute "homework assignment" of 30 minutes of video-guided yoga practice.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/11/2023
Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts
Conditions: Chronic Pain
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EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines
NCT04607460
Recruiting
The purpose of this pilot efficacy study is to examine the effects of EMG-biofeedback (EMG-BF) on pain-related outcomes in Chronic Low Back Pain (CLBP) patients, Recent mastectomy and lumpectomy patients, and patients with episodic migraine. EMG-BF facilitates neuromuscular retraining and muscle relaxation by using audio and visual stimuli using an EMG surface electrode-based biosensor and a software installed on a tablet or smart phone. For this pilot efficacy study, we will recruit 125 patie... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/11/2023
Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts
Conditions: Chronic Low-back Pain, Mastectomy, Lumpectomy, Migraine
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A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception
NCT04143659
Recruiting
This is a Phase I multicenter, open-label, dose-ranging, three-dose PK and PD study of injectable LB administered as an IM or SQ injection at 40 mg, and subsequently at 50mg SQ and then 60 mg SQ depending on the preliminary pharmacokinetic and pharmacodynamic results obtained with 40 mg dosing.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
08/11/2023
Locations: Boston Medical Center Corporation, Boston, Massachusetts
Conditions: Healthy Women, Female Contraception
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Preterm Lung Patient Registry
NCT00951366
Recruiting
The goal of the Preterm Lung Patient Registry is to collect data on individuals with neonatal lung disease to better understand the illness and ultimately improve their care and survival. The Patient Registry was established in 2008 as a means to monitor important trends in the BPD population and to improve understanding, treatment, and survival.
Gender:
ALL
Ages:
All
Trial Updated:
08/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Bronchopulmonary Disease
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Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
NCT00499317
Recruiting
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a condition with several causes of which some remain unknown. It is believed that some types of CP may be genetic or passed down (inherited) from one generation to the next. In this study, we are collecting genetic material and medical information to try to determine if genetic factors play a role in CP/CPPS. We will be collecting DNA (from Blood/Saliva sample) and urine from each participant. Bladder tissue from affected individuals... Read More
Gender:
MALE
Ages:
All
Trial Updated:
08/09/2023
Locations: Boston Children's Hospital (BCH), Boston, Massachusetts
Conditions: Chronic Prostatitis (CP), Chronic Pelvic Pain Syndrome (CPPS), Painful Bladder Syndrome (PBS), Benign Frequency Syndrome (BFS), Interstitial Cystitis
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