Massachusetts is currently home to 3220 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions
NCT05165186
Recruiting
The overall objective of this study is to compare knowledge, decisional conflict, preferences, and caregiver burden over time caregivers of Alzheimer's Disease and Related Dementias (ADRD) patients by comparing the effectiveness of a video decision aid intervention and enhanced usual care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Dementia, Dementia Frontotemporal, Dementia Alzheimers, Dementia, Mild, Dementia Moderate, Dementia Severe, Caregiver Burnout, Caregiver Stress Syndrome
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Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
NCT04940663
Recruiting
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutic... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
10/17/2023
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Psychosis, Schizophrenia
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VE416 for Treatment of Food Allergy
NCT03936998
Recruiting
This is a single-center, randomized, double-blind trial with four arms evaluating VE416 as pretreatment or concurrent treatment in comparison to low-dose peanut oral immunotherapy (PNOIT) alone.
Gender:
ALL
Ages:
Between 12 years and 55 years
Trial Updated:
10/17/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Peanut Allergy
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Identifying Sleep Apnea Patients That Best Respond to Atomoxetine Plus Oxybutynin Therapy
NCT05550246
Recruiting
Atomoxetine-plus-oxybutynin therapy (AtoOxy) has been shown to substantially reduce obstructive sleep apnea severity (OSA) in about half of patients. Here, the investigators will study which patients respond meaningfully to therapy using pathophysiological traits measured at baseline sleep studies.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
10/16/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
Register for Updates
Responders to Rhythmic Auditory Stimulation in Individuals Post-Stroke and Older Adults
NCT06085248
Recruiting
Stroke is among the leading causes of long-term disability worldwide. Post-stroke neuromotor impairments are heterogeneous, yet often result in reduced walking ability characterized by slow, asymmetric, and unstable gait patterns. Rhythmic Auditory Stimulation (RAS) is an emerging rehabilitation approach that leverages auditory-motor synchronization to retrain neuromotor control of walking. Indeed, walking with RAS can enhance walking rhythmicity, gait quality, and speed. RAS is a potentially va... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/13/2023
Locations: Boston University Neuromotor Recovery Laboratory, Boston, Massachusetts
Conditions: Stroke, Old Age
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Ixekizumab for the Management of Refractory Non-Infectious Uveitis: A Proof-of-Concept Study
NCT06085079
Recruiting
The objective of this study is to explore the efficacy of ixekizumab in treating patients with a diagnosis of non-infectious intermediate, posterior, panuveitis, or chronic steroid-dependent anterior uveitis who had failed treatment with a classic synthetic DMARD including methotrexate, mycophenolate, cyclosporin, azathioprine, cyclophosphamide and/or at least one anti-TNF agent including adalimumab, infliximab, etanercept, golimumab or certolizumab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts
Conditions: Uveitis, Posterior, Uveitis, Anterior, Uveitis, Intermediate, Panuveitis
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Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services
NCT06082999
Recruiting
Overall, this observational cohort study aims too: 1. Implement rapid trio WGS for all children presenting to our health systems with epilepsy onset under 12 months of age. 2. Utilize electronic healthcare records and research databases to unite phenotypic and genomic data and to create a "virtual" registry across all institutions that will promote ongoing discovery. 3. Assess the impact of early genetic diagnosis on epilepsy, developmental, and health economic outcomes through formal longitudi... Read More
Gender:
ALL
Ages:
12 months and below
Trial Updated:
10/11/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Epilepsy
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Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations
NCT04042831
Recruiting
This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene mutations. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Bile Duct Adenocarcinoma, Fanconi Anemia Complementation Group Gene Mutation, Metastatic Bile Duct Carcinoma, PTEN Gene Deletion
Register for Updates
Evaluating the Safety and Efficacy of Oral Encapsulated Microbiota Transplantation Therapy in Peanut Allergic Patients
NCT05695261
Recruiting
This is a phase II randomized double-blind placebo-controlled trial that aims at evaluating the safety and tolerability of oral encapsulated fecal microbial transplantation therapy (MTT) in peanut allergic patients. In this research the investigators would like to learn more about ways to treat peanut allergies. The primary objective is to evaluate whether MTT with antibiotic pretreatment can increase the threshold of peanut reactivity during a double-blind placebo-controlled food challenge from... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
10/10/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Allergy, Peanut, Peanut Allergy, Peanut Hypersensitivity, Peanut-Induced Anaphylaxis, Food Allergy, Food Allergy Peanut
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Use of Intraoral Suction and Its Effects on Obstructive Sleep Apnea
NCT05489562
Recruiting
To learn whether stabilization of the tongue using intraoral suction is tolerable and what effects this approach has on sleep parameters in obstructive sleep apnea.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/10/2023
Locations: VA Boston Healthcare System, Jamaica Plain, Massachusetts
Conditions: Obstructive Sleep Apnea of Adult
Register for Updates
Extracellular RNA Biomarkers of Duchenne Muscular Dystrophy
NCT05016908
Recruiting
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of muscular dystrophies by examining a urine sample and a blood sample.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
10/10/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Duchenne Muscular Dystrophy
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Hypoglycemia and the Gut Microbiome
NCT03385707
Recruiting
This study is designed to evaluate individuals who are currently experiencing symptoms of hypoglycemia, in order to discern correlations between microbiome composition and patterns of postprandial glycemia.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/10/2023
Locations: Joslin Diabetes Center, Boston, Massachusetts
Conditions: Hypoglycemia
Register for Updates