Massachusetts is currently home to 3202 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
LUT014 for the Reduction of Dose-Limiting Acneiform Lesions Associated With EGFRI Treatment of mCRC
NCT04759664
Recruiting
The study evaluates the efficacy and safety of two strengths of LUT014 Gel topically applied once a day for 4 weeks, compared to placebo, in metastatic colorectal cancer (mCRC) patients who developed Grade 2 or non-infected Grade 3 EGFRI induced acneiform lesions
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/05/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: EGFRI Induced Acneiform Lesions
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Gamma-Music Based Intervention for Mild Alzheimer's Disease
NCT05984524
Recruiting
The study will test and refine a novel brain-stimulation tool using gamma-frequency lights coupled with self-selected music for a gamma-music-based intervention for participants with mild Alzheimer's Disease. Results will yield a gamma-stimulation protocol that reliably influences brain activity (Aim 1), is adaptive, motivating and rewarding to use (Aim 2), and will generate predictions as to who might benefit the most from gamma-MBI (Aim 3). By bridging the gap between neurostimulation and beha... Read More
Gender:
ALL
Ages:
Between 50 years and 95 years
Trial Updated:
10/04/2023
Locations: Northeastern University, Boston, Massachusetts
Conditions: Alzheimer Disease
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Biomarker Development for Muscular Dystrophies
NCT05019625
Recruiting
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of muscular dystrophies by examining a urine sample and a blood sample, and some muscles in the arms and legs using t... Read More
Gender:
ALL
Ages:
5 years and above
Trial Updated:
10/04/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Myotonic Dystrophy, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy
Register for Updates
Extracellular RNA Biomarkers of Myotonic Dystrophy
NCT05020002
Recruiting
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of muscular dystrophies by examining a urine sample and a blood sample.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
10/04/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Myotonic Dystrophy
Register for Updates
Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant
NCT05709912
Recruiting
The goal of this research study is to determine whether a self-administered, psychosocial mobile application (CARE app) is effective at improving the quality of life and experience of caregivers of patients receiving hematopoietic stem cell transplantation (HCT).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Bone Marrow Transplant Complications, Hematologic Malignancy
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Psychosocial Mobile App for Chronic Graft-Versus-Host Disease
NCT05690971
Recruiting
The purpose of this research study is to see whether a psychosocial mobile app called Horizons is effective at improving quality of life, symptom burden, psychological distress, and coping in patients living with chronic graft-versus host disease (GVHD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Chronic Graft-Versus-Host Disease, Allogeneic Stem Cell Transplant
Register for Updates
SMART Trial to Predict Anhedonia Response to Antidepressant Treatment
NCT05537584
Recruiting
The main goal of this research is to use behavioral, brain, and clinical data to determine which type of antidepressant might be optimal before people with depression start treatment.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
10/02/2023
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Major Depressive Disorder
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Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome
NCT05875948
Recruiting
This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Hepatorenal Syndrome, Acute Kidney Injury
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Comparative Study of the Tomey OA-2000, Tomey CASIA2, and the LenStar LS900
NCT06065072
Recruiting
This is a prospective comparative study that will be conducted at one clinical site in the United States, in which subjects who sign an informed consent form and fulfil all inclusion and exclusion criteria, will have OCT scans obtained using the test and the predicate devices. There will be two main types of analyses performed as part of this study, including 1) a precision analysis, and 2) an agreement analysis. The precision analyses will be conducted utilizing all complete complements of ac... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
09/26/2023
Locations: NorthEast Eye Research Associates, Woburn, Massachusetts
Conditions: Cataract, Aphakic Eye, Pseudophakia
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A Study to Evaluate the Safety, Tolerability, and Exploratory Efficacy of IMS001 in Subjects With Multiple Sclerosis
NCT04956744
Recruiting
This is a Phase 1 study of IMS001, given as a single dose to subjects with Multiple Sclerosis who experience inadequate response and/or intolerability to disease modifying treatments. IMS001 is a human embryonic cell derived (hESC) mesenchymal stem cell (MSC). MSCs have the potential to modulate disease course.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/26/2023
Locations: UMass Memorial Medical Center, Worcester, Massachusetts
Conditions: Multiple Sclerosis
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Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol
NCT03216525
Recruiting
To determine if Alvimopan during open or robotic radical cystectomy with urinary diversion results in quicker return of bowel function (GI-2 recovery = time to upper \[first toleration of solid food\] and lower \[first bowel movement\] gastrointestinal recovery) compared to placebo.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
09/26/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Bladder Cancer
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Shwachman Diamond Syndrome Registry and Study
NCT06056908
Recruiting
Shwachman-Diamond syndrome (SDS) is a genetic condition characterized by bone marrow failure, medical co-morbidities, and leukemia predisposition. SDS-Like patients share clinical features with SDS but lack mutations in known SDS genes. Since SDS/SDS-Like syndromes are rare diseases, data are sparse regarding the clinical features, natural history, clinical outcomes with current management, and treatment. For this reason, the SDS Registry was formed to collect clinical data from medical records... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/25/2023
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Shwachman-Diamond Syndrome, Shwachman-Diamond Syndrome-Like
Register for Updates