Massachusetts is currently home to 3175 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Transcutaneous Carbon Dioxide Monitoring in Neonates Receiving Therapeutic Hypothermia for Neonatal Encephalopathy
NCT04603547
Recruiting
The aim of our study is to evaluate the feasibility of applying transcutaneous CO2 monitoring (tcPCO2) in neonates receiving therapeutic hypothermia and to quantify the agreement between tcPCO2 and PCO2 in this population with or without respiratory support. Although, transcutaneous measurement of CO2 tension is the most commonly used non-invasive CO2 monitoring system in neonatal intensive care, to date tcPCO2 technique has not been evaluated systematically or used routinely in the intensive ca... Read More
Gender:
ALL
Ages:
Between 0 days and 3 days
Trial Updated:
08/08/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Neonatal Encephalopathy
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Just in Time Cardio Pulmonary Resuscitation Trial
NCT05983640
Recruiting
The objective is to evaluate the effectiveness of a Just in Time (JiT) video as compared to the AHA Heartsaver® Course and no training (control) in ability to correctly perform CPR. The secondary objective is to assess skill retention 3-9 months after the AHA Heartsaver course with and without JiT Video use. The goal of this work is to study the effectiveness of this new JiT video to improve objective knowledge- and performance-based measures of effective OHCA response, as well as subjective rat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Gillette Stadium, Foxboro, Massachusetts
Conditions: Cardiopulmonary Arrest With Successful Resuscitation, Educational Problems
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MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine
NCT01788410
Recruiting
The objective of this study is to provide pain relief to patients with facet joint disease or head and neck pain related to compression of a nerve root. The goal is to provide palliative care with superior efficacy and longer relief compared to current methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Facet Joints; Degeneration, Neuropathy, Neuralgia
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Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
NCT04557891
Recruiting
There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated with anxiety disorders; structures such as the amygdala. In this double-blind sham-controlled clinical trial, the investigators propose to establish baseline severity of anxiety in 48 patients, then deliver eight treatments over four sessions of focused... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/04/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Generalized Anxiety Disorder
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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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Adapting the Tumor Board Model for Mental Illness and Cancer
NCT05837598
Recruiting
This study examines the feasibility and acceptability of a virtual tumor board for cancer and mental illness for patients with serious mental illness and a new cancer diagnosis. The study also examines the impact on patient care, psychiatric symptoms, and clinician self-efficacy in managing this population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2023
Locations: Mass General/North Shore Center for Outpatient Care, Danvers, Massachusetts
Conditions: Cancer, Severe Major Depression, Schizophrenia, Bipolar Disorder, Lung Cancer, Breast Cancer, Head and Neck Cancer, Gastrointestinal Cancer, Genitourinary Cancer
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Feasibility of [11C]Acetate-PET in LAM and TSC
NCT05467397
Recruiting
This study aims to assess \[11C\]acetate positron emission tomography (PET)/computed tomography (CT) as a biomarker for renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM) and an early biomarker of response to rapamycin in LAM patients. \[11C\]Acetate is a radioactive form of acetate, a nutrient commonly processed in our body's cells to generate fat and energy. Preclinical studies support the hypothesis that TSC tumors enhance lipid synthesis compared to normal tissues, suggestin... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/28/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Lymphangioleiomyomatosis, Tuberous Sclerosis Complex
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Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
NCT05976659
Recruiting
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD) in the context of dementia.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/27/2023
Locations: Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts
Conditions: Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases, Memory Disorders, Depressive Disorder
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Groningen International Study on Sentinel Nodes in Vulvar Cancer-III
NCT05076942
Recruiting
Vulvar cancer patients with SN-metastasis \> 2mm will receive chemoradiation instead of an inguinofemoral lymphadenectomy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: Baystate Medical Center, Springfield, Massachusetts
Conditions: Vulvar Cancer, Sentinel Lymph Node, Lymph Node Metastases
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COVID-19-Related Opioid Treatment Policy Evaluation
NCT05028998
Recruiting
Our nation is facing the COVID-19 pandemic during an ongoing opioid epidemic. Effective treatment for patients with opioid use problems involves a treatment method called Medication-Assisted Treatment, or MAT. In MAT, patients receive a medication that reduces cravings and withdrawal symptoms and can prevent overdose. Patients also receive counseling. Because the medications that are used in MAT are controlled substances, this treatment is subject to a number of federal regulations. The need for... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Opioid-use Disorder, Alcohol Use Disorder
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Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects
NCT02416674
Recruiting
Abdominal wall transplantation surgery is the transfer of abdominal wall tissues from a deceased human donor to a patient with a large abdominal wall defect. Abdominal wall transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of patients with large abdominal wall defects. The purpose of this study is to develop the best practices for abdominal wall transplantation that will improve the outcomes of future abdominal wall transplant rec... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/26/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Abdominal Wall Defect
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Project 3 Example: Human-AI Collaboration Tester (HAICT) Exp. 7
NCT05272189
Recruiting
The study is one part of a "bundle" of experiments that constitute Project Three of a National Eye Institute grant. Project Three includes a series of experiments that investigate how changing the input from a simulated AI can affect the decisions made by human observers in a two-alternative forced choice task (like the decision to recall a woman for further examination in mammography). HAICT 7, the experiment described here, investigates how changing prevalence affects human performance when AI... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: Visual Attention Lab / Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Decision Making, Computer Aided Diagnosis
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