Massachusetts Clinical Trials

A listing of Massachusetts clinical trials actively recruiting patient volunteers.

Well known as the home of Harvard University, Massachusetts' capital of Boston was one of the most consequential cities in the American Revolution. Everywhere you go, you'll find preserved structures, monuments, and museums – whether in Salem, Plymouth, or Cambridge. Massachusetts was among the first states to require its residents to hold health insurance, an initiative by Republican Gov. Mitt Romney which eventually informed the Affordable Care Act. Since that time, Massachusetts has continued to stand out as a healthcare leader. With more than 1,000 beds and over 12,500 full-time employees, Massachusetts General Hospital is its top provider, located in Boston.

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3205 trials found

Afatinib With CT and RT for EGFR-Mutant NSCLC


This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug to learn whether the drug works in treating a specific cancer. "Investigational" means that the drug is still being studied and that study doctors are trying to find out more about it-such as the safest dose to use, the side effects it may cause, and if the drug is effective for treating different types of cancer. It also means that the FDA has not yet approved the drug fo ...

Conditions: Lung Cancer

Artisan Aphakia Lens for the Correction of Aphakia (Secondary) in Adults


This study will determine the safety and effectiveness of the Artisan Aphakia Lens when used as a secondary implant to correct aphakia in adults.

Conditions: Aphakia
Phase: Not Applicable

Artisan Aphakia Lens for the Correction of Aphakia in Children


The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children.

Conditions: Aphakia

A ProspectiveTrial Using Video Images in Advance Care Planning in Hospitalized Seriously Ill Patients With Advanced Cancer


The purpose of this study is to compare the decision making of hospitalized subjects with advanced cancer having a verbal discussion about CPR compared to subjects using a video.

Conditions: Advanced Cancer
Phase: Not Applicable

Product Surveillance Registry


The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by streamlining the clinical surveillance process and facilitating leading edge performance assessment via the least burdensome approach.

Conditions: Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders, Digestive Disorders, Intracranial Aneurysm, Mechanical Circulatory Support, Respiratory Therapy, Aortic, Peripheral Vascular and Venous Disorders, Minimally Invasive Surgical Procedures, Diagnostic Techniques and Procedures, Surgical Procedures, Operative, Renal Insufficiency

Prospective Screening for Breast Cancer-related Lymphedema


The primary objectives of this study are twofold: 1) to detect and determine the level of symptoms, functional disability, and changes in quality of life that breast cancer patients experience from changes in their arms during and after treatment for breast cancer by collecting patient reported outcome measures, objective measurements, and clinical information in a prospectively maintained database and 2) to improve breast cancer-related lymphedema outcomes by early detection using objective mea ...

Conditions: Lymphedema

Atypical Hemolytic-Uremic Syndrome (aHUS) Registry


Post-marketing safety data on patients treated and untreated with eculizumab or ravulizumab.

Conditions: Atypical Hemolytic-Uremic Syndrome

Studying Tumor Tissue Samples From Patients With Early-Stage Non-Small Cell Lung Cancer


This research trial studies biomarkers in predicting the risk of cancer returning after surgery in tissue samples of patients with early-stage non-small cell lung cancer. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer and predict how well patients will respond to treatment.

Conditions: Lung Cancer

Hypofractionated Stereotactic Body Radiation Therapy as a Boost to the Prostate


In this study, participants will have standard Androgen Deprivation Therapy and undergo standard external beam radiation therapy to the prostate and at-risk lymph nodes by Intensity Modulated Radiation Therapy. The subsequent *boost* radiation therapy to the prostate alone will be given using the CyberKnife, rather than using the standard Intensity Modulated Radiation Therapy. This study will also see how CyberKnife affects the quality of the participant's life.

Conditions: Prostate Cancer
Phase: Not Applicable

ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators


The investigators propose a test of causality by examining a cohort of patients undergoing deep brain stimulation (DBS) within the ventral striatum. The investigators will examine behavior on and off stimulation across a range of tasks that index different forms of impulsivity. Patients will be studied in both the ON and OFF state - that is, they will be tested during active deep brain stimulation and 30 min to 1 hour after stimulation has been stopped (order of state will be counterbalanced acr ...

Conditions: Obsessive Compulsive Disorder, Major Depressive Disorder

Regional Distribution Differences Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation


Neurally adjusted ventilatory assist (NAVA) is an FDA approved mode of mechanical ventilation. This mode of ventilation is currently in routine use in adult, pediatric and neonatal intensive care units. The electrical activity of the diaphragm, the largest muscle used during inspiration, is measured. The ventilator triggers (synchronizes patient effort) and applies proportional assistance based on measured electrical activity of the diaphragm (Edi). This electrical activity is measured through a ...

Conditions: Respiratory Failure

Long-Term Safety Study Of Tofacinib In Patients With Juvenile Idiopathic Arthritis


Evaluate long-term safety and tolerability of tofacitinib in patients with JIA, who have previously participated in tofacitinib JIA studies.

Conditions: Juvenile Idiopathic Arthritis