Massachusetts is currently home to 3366 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564
Recruiting
This study is a postmarketing requirement jointly carried out by four NDA holders (Bayer AG, Bracco, GE Healthcare and Guerbet) and the CRO IQVIA. The study aims to create detailed images of the organs and tissue of the human body during x-ray, CT-scan or MRI investigations, doctors are using contrast media (a kind of dye) which can be given to patients by injection into a blood vessel or by mouth. In this study researchers want to find out whether so called gadolinium-based contrast agents (G... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
01/08/2023
Locations: Massachussets General Hospital, Boston, Massachusetts
Conditions: Motor Function, Cognitive Function, Contrast Media
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A Pilot Study of Ambulatory Heart Rate Variability Biofeedback for Substance Use Disorder
NCT05454657
Recruiting
Heart rate variability biofeedback (HRVB) is an biobehavioral intervention involving rhythmic breathing at resonance frequency that stimulates cardiovascular regulatory systems to help individuals better regulate affect and bolster cognitive control. This intervention has already shown its potential as a substance use disorder (SUD) treatment tool, but practical limitations of its accessibility, labor intensiveness, and cost have previously prevented this intervention from going to scale. Second... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/06/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Substance Use Disorders
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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
NCT01696721
Recruiting
In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it is associated with less severe long term side effects. However, there is limited published data demonstrating these results. The goal of the Proton and Photon Consortium Registry (PPCR) is to enroll children treated with radiation in order to describe the population that... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
01/05/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Pediatric Patients Treated With Radiation Therapy
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Proton RT for the Treatment of Pediatric Rhabdomyosarcoma
NCT00592592
Recruiting
The main purpose of this study is to see if using proton beam radiation therapy instead of photon beam radiation therapy can reduce side effects from radiation treatment for rhabdomyosarcoma. Photon beam radiation is the standard type of radiation for treating most rhabdomyosarcoma and many other types of cancer. Photon beam radiation enters the body and passes through healthy tissue, encounters the tumor, then leaves the body through healthy tissue. A beam of proton radiation enters the body an... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
01/05/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Rhabdomyosarcoma
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Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
NCT05672030
Recruiting
The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/04/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Nasal Polyps, Aspirin-exacerbated Respiratory Disease
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Development of a Training Intervention to Improve Mental Health Treatment for Gender Minority Youth
NCT05626231
Recruiting
The overall goal of the larger 3-aim study is to develop and pilot test a training intervention to increase mental health providers' use of gender-affirming practices with gender minority youth (GMY; children, adolescents, and young adults whose gender is different from their birth-assigned sex). Aim 3 (registered here) of the study is an open trial pilot study at a multi-clinic mental health agency, aimed at examining the feasibility and acceptability of conducting a future randomized controlle... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
01/03/2023
Locations: Boston College, Chestnut Hill, Massachusetts
Conditions: Knowledge, Attitudes, Practice
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Esophageal Pressure Measurements During One-lung Ventilation
NCT04725318
Recruiting
The investigators will assess the feasibility and validity of esophageal pressure measurements during one-lung ventilation in the lateral position for surgery by comparing to lung collapse estimated from electrical impedance tomography during a PEEP trial.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/03/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Surgery, One-lung Ventilation
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Defibrotide for the Treatment of Severe COVID-19
NCT04652115
Recruiting
The goal of this study is to evaluate the safety and feasibility of defibrotide in COVID-19 pneumonia.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
01/03/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Covid19
Register for Updates
Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury
NCT04458324
Recruiting
Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI). Functional Electrical Stimulation Row Training (FESRT) couples volitional arm and electrically controlled leg exercise, resulting in the benefits of large muscle mass exercise. However, despite the potential for enhancing aerobic capacity by training the denervated leg skeletal muscle via hybrid FES exercise, the inability to increase venti... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
01/03/2023
Locations: Spaulding Hospital Cambridge, Cambridge, Massachusetts
Conditions: Spinal Cord Injuries
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Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline
NCT04009382
Recruiting
The aim of this study is to investigate the modulation effects of Baduanjin (BDJ), a simple and innovative mind-body exercise, on cognitive function, resting state functional connectivity, and brain morphometry in individuals with subjective cognitive decline (SCD). The results obtained will provide novel insights for improving the prevention of age-related cognitive decline and Alzheimer's disease.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
12/29/2022
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Cognitive Decline
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Brain Mechanisms of Video-Guided Acupuncture Imagery Treatment on Chronic Low Back Pain
NCT03765879
Recruiting
In this study, the investigators will examine the analgesic effects of acupuncture imagery treatment in patients with chronic low back pain. The intervention used in this study is "video-guided acupuncture imagery treatment" (VGAIT) treatment. The control used in this study is sham (fake) VGAIT. Participants in each group will participate in 8 study sessions (including 6 treatment sessions) over the course of 6 weeks. The primary outcome measure for this study is change in low back pain severity... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
12/29/2022
Locations: Massachusetts General Hospital, Charlestown, Massachusetts
Conditions: Chronic Pain
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Neuromodulation of Lidocaine Cream Effect on Chronic Pain Patients
NCT03046017
Recruiting
Chronic low back pain patients aged 21 to 60 needed for a research study of the effects of transcranial direct current stimulation (tDCS) on the analgesic effects of lidocaine cream as measured by functional Magnetic Resonance Imaging (fMRI). Study will be conducted on nine separate days not requiring an overnight stay in the hospital.
Gender:
All
Ages:
Between 21 years and 60 years
Trial Updated:
12/29/2022
Locations: Martinos Center for Biomedical Imagin, Charlestown, Massachusetts
Conditions: Chronic Low Back Pain
Register for Updates