Massachusetts Clinical Trials

A listing of Massachusetts clinical trials actively recruiting patient volunteers.

Well known as the home of Harvard University, Massachusetts' capital of Boston was one of the most consequential cities in the American Revolution. Everywhere you go, you'll find preserved structures, monuments, and museums – whether in Salem, Plymouth, or Cambridge. Massachusetts was among the first states to require its residents to hold health insurance, an initiative by Republican Gov. Mitt Romney which eventually informed the Affordable Care Act. Since that time, Massachusetts has continued to stand out as a healthcare leader. With more than 1,000 beds and over 12,500 full-time employees, Massachusetts General Hospital is its top provider, located in Boston.

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3205 trials found

Patient and Healthcare Professional Views on Genetic/Genomic Information and Testing

NCT04733274

Technologic advances (i.e. next generation sequencing technologies and novel bioinformatics approaches) have been drivers of scientific discovery and have deepened our understanding of the genetics and genomics of health and disease. In parallel, the falling cost of sequencing has led to screening moving from specialty clinics into the primary care setting. However, our ability to help patients and families understand these technologies and related genetic health literacy issues lag behind. Thes ...

Conditions: Hypogonadism, Hypogonadotropic, Kallmann Syndrome

A Nurse-led, Advance Care Planning Intervention in the Emergency Department

NCT04730986

ED GOAL is a 6-minute, motivational interviewing, advance care planning intervention. In this study, the investigators will pilot test (Part I) ED GOAL by training research nurses to demonstrate its intervention fidelity and acceptability on older adults with serious illness in the emergency department (ED). Upon demonstrating the intervention fidelity of this intervention in Part I, the investigators will collect patient-centered outcomes (Part II) of 100 older adults with serious illness afte ...

Conditions: Emergency Department, Motivational Interviewing, Advance Care Planning
Phase: Not Applicable

Clinical Evaluation to Demonstrate the Safety and Performance of the Candela PicoWay System™

NCT04727099

This study is intended to demonstrate the safety and efficacy of the PicoWay™ Laser System for its intended uses: clearance of benign pigmented lesions and improvement in appearance of wrinkles.

Conditions: Wrinkle, Pigmented Lesions
Phase: Not Applicable

Study of XL102 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

NCT04726332

This is a Phase 1, open-label, dose-escalation and expansion study evaluating the safety, tolerability, PK, antitumor activity, and effect on biomarkers of XL102 administered orally alone and in multiple combination regimens to subjects with advanced solid tumors.

Conditions: Neoplasm Malignant, Epithelial Ovarian Cancer, Triple Negative Breast Cancer, Hormone Receptor Positive Breast Carcinoma, Metastatic Castration-resistant Prostate Cancer

Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings

NCT04726371

Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings is a research study aimed at developing, implementing, and evaluating a package of interventions specifically designed to reduce COVID-19 and other infectious-disease incidence, hospitalizations, and mortality among staff and adults with Serious Mental Illness and Intellectual and Developmental Disabilities in congregate-living settings.

Conditions: Intellectual Disability, Developmental Disability, Axis I Diagnosis, Mental Illness, Covid19, Coronavirus
Phase: Not Applicable

VIR-1111: A Prototype Human CMV-based Vaccine for Human Immunodeficiency Virus (HIV) in Healthy Volunteers

NCT04725877

This is a Phase 1a, first in human study in which healthy adult participants who are considered to be at low-risk for HIV infection and are seropositive for cytomegalovirus (CMV) will receive two doses of VIR-1111 or placebo. These participants will be assessed for safety, reactogenicity, tolerability and immunogenicity. There is an optional long-term follow-up study that would lengthen study participation for up to 3 years post-first dose.

Conditions: HIV I Infection

Translational Research Center for TBI and Stress Disorders: Virtual Assessment of Deployment Trauma and Rehabilitation

NCT04723745

For this clinical demonstration study, Veterans will be assessed with a battery of questionnaires/surveys and a 1:1 clinical interview with a V-TRACTS psychologist to target domains of head injury, psychological trauma, depression, suicidality, anxiety, chronic pain and sleep, substance use and activity level. V-TRACTS will convene a weekly consensus meeting to evaluate all the data, and develop a recommendation plan. After the consensus meeting, a V-TRACTS psychologist will provide comprehensiv ...

Conditions: TBI (Traumatic Brain Injury), PTSD

Esophageal Pressure Measurements During One-lung Ventilation

NCT04725318

The investigators will assess the feasibility and validity of esophageal pressure measurements during one-lung ventilation in the lateral position for surgery by comparing to lung collapse estimated from electrical impedance tomography during a PEEP trial.

Conditions: Surgery, One-lung Ventilation

Healthy Eating Education for Latinos

NCT04724382

This intervention aims to evaluate the efficacy of a pilot educational intervention with deep-structure cultural tailoring for Latino ethnic groups on diet quality compared to general, surface-level healthy-eating messages.

Conditions: Diet, Healthy, Diet Habit, Obesity, Blood Pressure, Psychological
Phase: Not Applicable

Evaluation of the Evoke Radiofrequency Device for Improvement of Skin Appearance

NCT04721600

Evaluation of the Evoke Radiofrequency Device for Improvement of Skin Appearance

Conditions: Skin Laxity
Phase: Not Applicable

Study to Characterize Rate of Ureagenesis in Patients With Ornithine Transcarbamylase (OTC) Deficiency

NCT04717453

The objectives of the study are to characterize urea production rates in patients with OTC, characterize the association of rate of ureagenesis and disease severity in OTC patients, characterize the association of rate of ureagenesis and executive and verbal function and characterize the association of rate of ureagenesis and patient-reported functional status.

Conditions: Ornithine Transcarbamylase Deficiency

Precision Gait Retraining for Children With Cerebral Palsy

NCT04717323

This project will develop the first sensor-based mobile Pelvic Assist Device (mPAD) that can deliver precise, adaptable, pelvic control to restore natural coordination of upper- and lower-limb movements during gait in children with Cerebral Palsy

Conditions: Cerebral Palsy, Gait Disorders, Neurologic
Phase: Not Applicable