Massachusetts Clinical Trials

A listing of Massachusetts clinical trials actively recruiting patient volunteers.

Well known as the home of Harvard University, Massachusetts' capital of Boston was one of the most consequential cities in the American Revolution. Everywhere you go, you'll find preserved structures, monuments, and museums – whether in Salem, Plymouth, or Cambridge. Massachusetts was among the first states to require its residents to hold health insurance, an initiative by Republican Gov. Mitt Romney which eventually informed the Affordable Care Act. Since that time, Massachusetts has continued to stand out as a healthcare leader. With more than 1,000 beds and over 12,500 full-time employees, Massachusetts General Hospital is its top provider, located in Boston.

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3205 trials found

Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome


Individuals with Sturge-Weber Syndrome (SWS) sometimes have brain involvement which can result in seizures, stroke-like episodes and neurologic deficits. The purpose of this study is to integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. The research aims are: To integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. Identify plasma and imaging biomarkers sensitive to exacerba ...

Conditions: Sturge-Weber Syndrome

Study of Subcutaneous (Injected Under the Skin) Risankizumab to Assess Change in Disease Symptoms in Adult Participants With Moderate to Severe Plaque Psoriasis With Palmoplantar Involvement


Plaque Psoriasis is a chronic inflammatory disease in which skin cells build up and develop scaly red and white patches on the skin. It is caused by an overactive immune system where the body attacks healthy tissue by mistake. Palmoplantar (non-pustular) plaque psoriasis (PPPsO) represents a localized form of psoriasis in palms and soles. This study will evaluate how safe risankizumab is for the treatment of plaque psoriasis with palmoplantar involvement and to assess change in disease symptoms. ...

Conditions: Psoriasis

Program for Alleviating and Resolving Trauma and Stress 1


This single-arm pilot study (Phase 1) will test the preliminary efficacy of a virtually delivered, live-online 16-week group model of Internal Family Systems (IFS) for individuals with PTSD, called the PARTS program, on PTSD symptoms measured by Clinician-Administered PTSD Scale (CAPS-5). In addition, feasibility, acceptability, and effects on self-report PTSD and disturbances of self-organization (DSO) will be secondary outcomes.

Conditions: Post-traumatic Stress Disorder
Phase: Not Applicable

HEALthy Brain and Child Development Study - COVID-19 Supplement


The purpose of this study is to advance the scientific understanding of how a prenatal COVID-19 infection and associated psychological distress influences infant neurodevelopment. This project will aim to shed light on how families and child development are impacted by the current COVID-19 pandemic and will work to better support these families and children as they grow.

Conditions: Child Development, Prenatal Infection, Prenatal Stress, Covid19

Registry and Natural History Study for AP-4 Associated Hereditary Spastic Paraplegia (AP-4-HSP)


The Registry and Natural History Study for AP-4 Associated Hereditary Spastic Paraplegia (AP-4-HSP) is focused on gathering longitudinal clinical data as well as biological samples (skin and/or blood and/or saliva )from male or female patients of all ages with (1) a clinical diagnosis of hereditary spastic paraplegia and/or (2) the presence of variants in AP4-HSP related genes and/or be a relative of a person with such a diagnosis. Currently, the treatment for this disorder is generally symptoma ...

Conditions: Hereditary Spastic Paraplegia, SPG47, SPG50, SPG51, SPG52, AP4-related Hereditary Spastic Paraplegia

Endostapler Gastric Bypass Study


The goal of this prospective, post-market study is to evaluate safety and efficacy of the AEON™ Endostapler when used in laparoscopic Roux-en-Y gastric bypass surgery.

Conditions: Obesity

Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Brian Injury


The overall objective is to obtain an initial assessment of the value of using [18F]3F4AP for imaging demyelinating diseases such as traumatic brain injury (TBI), neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's Disease (AD): Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with traumatic brain injury (TBI) and neurocognitive impaired subjects (AD/MCI). Hypothesis 1: Administration of [18F]3F4AP will result in no changes in vitals or ot ...

Conditions: Brain Injuries, Traumatic, Demyelinating Disorder, Alzheimer Disease

Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes


This study compares three doses of once daily semaglutide tablets in people with type 2 diabetes who were previously treated with other oral anti-diabetic medicines. Participants will be initiated on the lowest starting dose of 3 mg and gradually increased until they reach the final trial dose of 14 mg, 25 mg or 50 mg once daily semaglutide tablets. The final three doses will be randomized (i.e., decided by chance). Participants will be administered one tablet per day for 68 weeks. Women cannot ...

Conditions: Diabetes Mellitus, Type 2

Pivotal 1 Study of RGX-314 Gene Therapy in Participants With nAMD


RGX-314 is being developed as a novel one-time gene therapy for the treatment of neovascular (wet) age-related macular degeneration (wet AMD). Wet AMD is characterized by loss of vision due to new, leaky blood vessel formation in the retina. Wet AMD is a significant cause of vision loss in the United States, Europe and Japan, with up to 2 million people living with wet AMD in these geographies alone. Current anti-VEGF therapies have significantly changed the landscape for treatment of wet AMD, b ...

Conditions: AMD, nAMD, Wet Age-related Macular Degeneration, wAMD, Wet AMD, CNV
Phase: Phase 2/3

Investigation of Brain Plasticity in Autism Spectrum Disorders


Individuals with autism spectrum disorders (ASD) commonly experience variances in tactile behaviors, such as hypersensitivity to light touch stimuli, altered texture discrimination, and hyporesponsivity to pain. Researchers aim to investigate the somatosensory sensitivity and sensorimotor integration utilizing novel, objective behavioral assays and TMS. The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disor ...

Conditions: Autism Spectrum Disorder

A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors


Researchers are looking for a better way to treat people with solid tumors. Before a treatment can be approved for people to take, researchers do clinical trials to better understand its safety and how it works. In this trial, the researchers want to learn about regorafenib taken together with nivolumab in a small number of participants with different types of tumors. These include tumors in the head and neck, the esophagus, the pancreas, the brain, and the biliary tract. The biliary tract incl ...

Conditions: Solid Tumors

Development and Implementation of Electronic Decision Aids for Genetic Testing in Inherited Cancer Syndromes


An electronic decision aid will be used to assist individuals in choosing a multi-gene panel with their medical oncologist instead of a genetic counselor. A decision aid may facilitate quality decisions around the selection of a specific multi-gene panel without a genetic counselor. Upon completion of the decision aid, participants will be asked to indicate their decision about whether to pursue genetic testing and which specific multi-gene panel to pursue. A survey will then be administered to ...

Conditions: Genetic Testing
Phase: Not Applicable