There are currently 241 active clinical trials seeking participants for Healthy research studies. The states with the highest number of trials for Healthy participants are California, Florida, Texas and Maryland.
Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI
NCT06763172
Recruiting
This research study aims to determine whether and how caffeine intake affects learning process through reward feedback compared to placebo. The data acquired from this study would improve our understanding on the consequence and mechanism of caffeine intake in the aspect of learning process. Participants will perform a reinforcement learning task (i.e. Probabilistic Selection Task) and a motor inhibition task (i.e. Go/NoGo task) in a brain scan. The scan will be done with the Siemens Biograph m... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
01/07/2025
Locations: Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts
Conditions: Healthy, Caffeine, Adenosine, Dopamine D2/3 Receptor Availability
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NPWT Reduction Mammaplasty
NCT06725459
Recruiting
In this prospective, randomized, split-body control trial, we aim to compare complications, patient-reported outcomes, and cost differentials following reduction mammaplasty with prophylactic closed incision negative pressure wound therapy versus standard adhesive dressing.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/03/2025
Locations: Medstar Georgetown University Hospital, Washington, District of Columbia
Conditions: Healthy, Macromastia, Negative Pressure Therapy, Mammaplasty, Wound Healing
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Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function
NCT05538247
Recruiting
This study is being done to assess the effects of S. boulardii CNCM I-745 compared to placebo on impaired intestinal permeability, which is the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall into the rest of the body.
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
01/02/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Healthy
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Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
NCT05301608
Recruiting
This research study will use computerized tasks, electroencephalography (EEG), and magnetic resonance imaging (MRI) to look at how the drug psilocybin, a naturally occurring compound contained in hundreds of species of psychoactive mushrooms, changes thoughts and brain activity.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/16/2024
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Healthy
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Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
NCT03759522
Recruiting
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-in... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/13/2024
Locations: University of Alabama at Birmingham Medical Center, Birmingham, Alabama
Conditions: Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
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The Longitudinal Study of Stimulant Use Disorder
NCT06073340
Recruiting
This research is a 5-year observational, longitudinal registry study with no treatment or medication provided as part of participation. Individuals with current or lifetime stimulant use disorder, in addition to healthy control individuals, may be eligible to participate in this study. A variety of assessments and tasks including Magnetic Resonance Imaging (MRI), Electroencephalography (EEG), blood draws, urine drug screens, and both self-report and clinician-rated assessments will be used to as... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
12/13/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Stimulant Use, Stimulant-Related Disorder, Healthy
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The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation
NCT04831398
Recruiting
the purpose of this experiment is to determine if acute melatonin supplementation alters central and peripheral cardiovascular responses to a cold pressor test at rest and during dynamic exercise.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
12/05/2024
Locations: Department of Health and Exercise Science, Norman, Oklahoma
Conditions: Healthy
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Carbon Dioxide (CO2) and Cognitive Impairment
NCT05292378
Recruiting
The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
12/04/2024
Locations: Rutgers - EOHSI, Piscataway, New Jersey
Conditions: Healthy
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Effects of an Antioxidant Supplement on Blood Vessel Health
NCT06424756
Recruiting
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and the non-Hispanic Black (NHB) population is disproportionately affected. Our research has previously demonstrated that oxidative stress may contribute to reduced vascular function in otherwise healthy NHB adults, potentially predisposing them to the development of hypertension and CVD. This study is designed to examine whether the mitochondria are an important source of oxidative stress-induced vascular dysf... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/04/2024
Locations: Ramsey Student Center, University of Georgia, Athens, Georgia
Conditions: Healthy
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Effects of Vibration on Motor Function of Survivors of Chronic Stroke
NCT06663501
Recruiting
The aim of this study is to evaluate how vibration of the tendons enhances arm and hand training in survivors of chronic stroke. The investigators hypothesize that wrist/elbow robotic training, combined with body awareness training will improve arm and hand function in individuals with chronic stroke.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/03/2024
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Stroke, Healthy
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Metabolic Effects of Fructose Intake
NCT06671756
Recruiting
The goal of this clinical trial is to learn how fructose ingestion affects metabolic factors in healthy adults aged 18-64, with a BMI between 19 and 30 kg/m², of any sex or gender. Specifically, the study aims to examine the impact of fructose compared to glucose on circulating metabolic factors including the soluble leptin receptor. The main questions it aims to answer are: How does fructose ingestion influence levels of circulating metabolic markers, including the soluble leptin receptor? Do... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
12/03/2024
Locations: Baylor St. Luke's Medical Center, Houston, Texas
Conditions: Healthy
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Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers
NCT06120244
Recruiting
Background: Infections in the lower respiratory tract (lungs) are the leading cause of death from infectious disease worldwide. This was true even before the COVID-19 pandemic. Respiratory viruses are still a major health threat. Many of these viruses infect people by penetrating the thin skin that lines the nose. These viruses can also spread easily to other people when they multiply in the tissues that line the nose. Researchers want to learn more about what these viruses do inside the nose,... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/03/2024
Locations: Rocky Mountain Laboratories, Hamilton, Montana
Conditions: Healthy
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