There are currently 230 active clinical trials seeking participants for Healthy research studies. The states with the highest number of trials for Autism participants are California, Florida, Texas and Maryland.
A Study of LY3502970 in Participants With Impaired and Normal Liver Function
Recruiting
The main purpose of this study is to measure how much of LY3502970 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to participants with normal liver function. The safety and tolerability of LY3502970 will also be evaluated. The study may last up to 6 weeks for each participant including the screening period.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/29/2024
Locations: Clinical Pharmacology of Miami, Miami, Florida +3 locations
Conditions: Healthy, Hepatic Insufficiency
Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
Recruiting
The purpose of this research is assess imaging and identification of soft plaque that undergoes large deformations or strain will identify plaque vulnerable to rupture which could lead to 'silent strokes'. Validation of current study results with MRI will foster use of real-time ultrasound (US) strain imaging and strain indices as a screening tool for identifying normal human participants susceptible to increased vascular aging and developing plaque prone to rupture or micro-embolization. Curre... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Department of Medical Physics, University of Wisconsin, Madison, Wisconsin
Conditions: Healthy, Carotid Artery Diseases
Phase 1, Dose Escalation Study to Evaluate of Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered Via a Single Intrathecal Injection to Healthy Volunteers
Recruiting
Primary Objective: To assess the safety and tolerability of Liposomal Bupivacaine 13.3 administered as a single intrathecal injection in healthy volunteers. Secondary Objective: To characterize the pharmacokinetic (PK) and pharmacodynamic (PD) profile of Liposomal Bupivacaine 13.3 administered as a single intrathecal injection in healthy volunteers.
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
01/26/2024
Locations: Duke University, Durham, North Carolina
Conditions: Healthy
Genesis Electrical Impedance Tomography (EIT): A Preliminary Study
Recruiting
The purpose of this study is to evaluate the Genesis Electrical Impedance Tomography (EIT) imaging system for use in pediatric respiratory disease populations including neuromuscular and bronchopulmonary dysplasia, as well as in age and height matched controls. The EIT does not use radiation, and is read through electrodes.
Gender:
All
Ages:
Between 14 days and 40 years
Trial Updated:
01/25/2024
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Premature Infant, Chronic Respiratory Disease, Neuromuscular Diseases, Healthy, Bronchopulmonary Dysplasia, Pulmonary Vein Stenoses
Supramaximal Walkouts and Back Squat Performance
Recruiting
The goal of this randomized, counterbalanced, crossover study is to determine the effectiveness of performing a supramaximal walkout on enhancing subsequent back squat performance in trained lifters. The main question we aim to answer is whether bar velocity, power output, perceived exertion, and muscle activation are altered when performing the back squat exercise after a supramaximal walkout. On the first visit, participants will be informed of the study protocols before providing oral and wri... Read More
Gender:
Male
Ages:
Between 18 years and 45 years
Trial Updated:
01/24/2024
Locations: Institute of Sports Sciences & Medicine, Tallahassee, Florida
Conditions: Healthy
A Relative Bioavailability Study of LY3454738 in Healthy Participants
Recruiting
The main purpose of this study is to look at the amount of the study drug, LY3454738 that gets into the blood stream and how long it takes the body to get rid of it when given under the skin comparing a test formulation versus a reference formulation in healthy participants. The study will also evaluate the safety and tolerability of LY3454738 and information about any side effects experienced will be collected. For each participant, the total duration of the study will be approximately up to 17... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/23/2024
Locations: ICON Early Phase Services, San Antonio, Texas
Conditions: Healthy
Measurement of Insulin Levels in Cerebral Spinal Fluid (CSF) of Healthy Adults After a Single Intranasal Dose
Recruiting
The purpose of this study is to find out whether insulin, a drug approved by the FDA for the treatment of diabetes mellitus, reaches the brain and spinal cord when delivered as a nasal spray (intranasally). Intranasal insulin has been shown to improve memory and mood in patients with mild cognitive impairment and dementia, but more evidence is needed to support the ability to effectively target the brain through intranasal routes. 12 healthy adults will be randomly assigned to receive a single... Read More
Gender:
All
Ages:
Between 18 years and 35 years
Trial Updated:
01/22/2024
Locations: HealthPartners Neuroscience Center, Saint Paul, Minnesota
Conditions: Healthy
A Study of Perturbation of Human Small Intestinal Colonic Permeability
Recruiting
The purpose of this study is to evaluate the effect of castor oil versus placebo on intestinal permeability in healthy individuals.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/22/2024
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Healthy
PK and Safety in Participants Taking Obicetrapib With Moderate Hepatic Impairment Relative to Normal Hepatic Function
Recruiting
To investigate the safety and pharmacokinetics in patients with moderate hepatic impairment compared to healthy participants after a single oral dose of obicetrapib (10 mg).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
01/20/2024
Locations: Nucleus Network, Saint Paul, Minnesota +1 locations
Conditions: Hepatic Impairment, Healthy
Alternation in the Human Microbiome With Commonly Used Topical Medications
Recruiting
The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the hum... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/19/2024
Locations: University of California, Davis, Department of Dermatology, Sacramento, California
Conditions: Healthy
The BrainHealth Project
Recruiting
For an overview of the study and link TO REGISTER please go to -- https://brainhealth.utdallas.edu/programs/the-brainhealth-project/ The BrainHealth Project is a ten-year, longitudinal study focused on identifying determinants of brain health and performance. Participants will have the opportunity to complete semi-annual (twice a year) online assessments to track their performance over time. In between semi-annual assessments, participants will have access to online trainings and ongoing supple... Read More
Gender:
All
Ages:
Between 18 years and 110 years
Trial Updated:
01/18/2024
Locations: The Center for BrainHealth at The University of Texas at Dallas, Dallas, Texas
Conditions: Healthy
A Study of LY3437943 in Healthy Participants With a High Body Mass Index
Recruiting
The study is conducted in two parts (Part A and B). The main purpose of this study is to look at the amount of the LY3437943 that gets into the blood stream and how long it takes the body to get rid of it when given subcutaneously (SC, under the skin) in the upper arm and thigh compared to the abdomen in healthy participants with high body mass index (BMI) in Part A. In Part B, the participants receive LY3437943 intravenously (IV, through a vein) where the safety and tolerability of LY3437943 ar... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
01/18/2024
Locations: Fortrea Clinical Research Unit, Daytona Beach, Florida
Conditions: Healthy