There are currently 241 active clinical trials seeking participants for Healthy research studies. The states with the highest number of trials for Healthy participants are California, Florida, Texas and Maryland.
Exploring the Influence of Sensory Cues on Eating Behavior Using Virtual Reality
NCT06662149
Recruiting
Many factors influence eating choices among humans (mood, taste, convenience, time of day, etc.). Finding simple ways to decrease food intake or improve food choices could improve weight status and overall health of the general population. The purpose of this study is to see if city and/or nature smells affect human eating behavior within a virtual reality-simulated outdoor café. The researchers of this study believe that a better understanding of how smells affect eating behavior could lead to... Read More
Gender:
ALL
Ages:
Between 18 years and 29 years
Trial Updated:
07/21/2025
Locations: Health, Ingestive Behavior, and Technology Laboratory of Pennsylvania State University, State College, Pennsylvania
Conditions: Healthy
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The ENHANCE Study: taVNS and Psilocybin
NCT05866471
Recruiting
This study will examine whether combining a single dose of psilocybin with non-invasive transcutaneous auricular vagus nerve stimulation (taVNS), a potential inducer of neuroplasticity and enhanced memory formation, will enhance the long-term beneficial behavioral effects of psilocybin when compared to sham taVNS or no VNS by allowing memory for insights gained during the psychedelic experience to remain vivid after they will have faded in subjects who receive psilocybin followed by sham taVNS o... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/21/2025
Locations: University of Wisconsin - Madison, Madison, Wisconsin
Conditions: Healthy, Psychedelic Experiences, Vagus Nerve Stimulation
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Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
NCT06480201
Recruiting
The core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a prognostic marker of 4-week treatment outcome. Previous research focused exclusively on KET-induced gamma band potentiation (GBP) in the context of a single infusion. Our study design captures the clinical variation associated with real-world treatment resistant depression (TRD) patients and allows us to analyze the relativ... Read More
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
07/17/2025
Locations: Wells Medicine, Houston, Texas +1 locations
Conditions: Healthy, Major Depressive Disorder, Treatment Resistant Depression
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A First-in-human Study to Evaluate the Safety and Tolerability of HB-2121 as a Diagnostic for Celiac Disease
NCT07063823
Recruiting
The goal of this clinical trial is to learn about the safety of a single dose of HB-2121 in adults. It will also look at how the body processes the drug. The main questions it aims to answer are: * What side effects do participants have after receiving HB-2121? * How much HB-2121 is in the blood over time? Researchers will follow participants for 30 days after receiving HB-2121 to understand how the drug behaves in the body and how safe it is. Participants will: * Receive one oral dose of HB... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2025
Locations: Stanford University, Stanford, California
Conditions: Celiac Disease, Healthy
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A Study of Lepodisiran (LY3819469) in Participants With Normal, Mild, Moderate, or Severe Liver Function
NCT06916078
Recruiting
The main purpose of this study is to evaluate how much lepodisiran gets into the blood stream and how long it takes the body to get rid of it when given as a subcutaneous (SC) injection under the skin to participants with mild, moderate, or severe liver function impairment compared to participants with normal liver function. The study will also evaluate how well lepodisiran is tolerated and what side effects may occur in these participants. The study will last up to approximately 9 weeks, exclu... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
07/17/2025
Locations: Clinical Pharmacology of Miami, Miami, Florida +3 locations
Conditions: Liver Dysfunction, Healthy
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Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
NCT06335771
Recruiting
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
Conditions: Obesity, Nonalcoholic Fatty Liver, Diabetes Type 2, Healthy
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Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
NCT06571474
Recruiting
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
Conditions: Obesity, Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2, Healthy
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Growth Hormone Resistance of Beta-cells in Women and People
NCT06571500
Recruiting
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
Conditions: Healthy, Obesity
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A Study of [14C]-LY4065967 in Healthy Participants
NCT07039045
Recruiting
The purpose of this study is to investigate the absorption, metabolism, excretion, and bioavailability of LY4065967 in healthy male participants. This is a 2-part study. The study will last about 58 days for participants in Part 1 and about 60 days for participants in Part 2.
Gender:
MALE
Ages:
Between 18 years and 55 years
Trial Updated:
07/16/2025
Locations: Fortrea Clinical Research Unit, Madison, Wisconsin
Conditions: Healthy
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Growth Hormone Resistance of Beta-cells
NCT06571487
Recruiting
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/16/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
Conditions: Gestational Diabetes, Obesity, Healthy
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Interhemispheric Connectivity and Compensation
NCT05207878
Recruiting
The goal of this study is to determine which parts of the brain make it possible for some people to move skillfully with their left non-dominant hand.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Peripheral Nerve Injury Upper Limb, Healthy
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CBD-Microglia PET Study
NCT04398719
Recruiting
This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/15/2025
Locations: Connecticut Mental Health Center, New Haven, Connecticut
Conditions: CBD, Healthy
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