Illinois is currently home to 2681 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Chicago, Peoria, Springfield and Urbana. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma
NCT05236036
Recruiting
This phase I/Ib trial tests the safety, side effects, and best dose of mycophenolate mofetil in combination with temozolomide and/or radiation therapy (standard of care) in treating patients with glioblastoma. Mycophenolate mofetil is an immunosuppressant drug that is typically used to prevent organ rejection in transplant recipients. However, mycophenolate mofetil may also help chemotherapy with temozolomide work better by making tumor cells more sensitive to the drug. The purpose of this trial... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/22/2022
Locations: Northwestern University, Chicago, Illinois
Conditions: Astrocytoma, Glioblastoma, Glioblastoma, IDH-Wildtype, MGMT-Unmethylated Glioblastoma, Recurrent Glioblastoma
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Breast Cancer Liquid Biopsy Trial
NCT04962529
Recruiting
The purpose of this study is to continue to develop a liquid biopsy (minimally invasive blood test) that can be used to confirm if breast cancer has spread throughout the body and if this liquid biopsy test can provide comparable information to a highly invasive tissue biopsy. The knowledge gained in this study could be used in future studies to confirm cancer recurrence using a safe and minimally invasive procedure. The research will consist of looking for tumor cell(s) circulating in the blood... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/08/2022
Locations: Northwest Community Hospital, Arlington Heights, Illinois
Conditions: Breast Cancer, Cancer
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Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer
NCT05486143
Recruiting
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2022
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Breast Cancer
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Zanubrutinib and CAR T-cell Therapy for the Treatment of Recurrent or Refractory Aggressive B-cell Non-Hodgkin's Lymphoma or Transformed Indolent B-cell Lymphoma
NCT05202782
Recruiting
This phase II trial studies the effect of zanubrutinib and CAR T-cell therapy in treating patients with aggressive B-cell non-Hodgkin's lymphoma or transformed indolent B-cell lymphoma that has come back (recurrent) or does not respond to treatment (refractory). Zanubrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. T cells are infection fighting blood cells that can kill tumor cells. The T cells given in this study will come from the patient and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/01/2022
Locations: Northwestern University, Chicago, Illinois
Conditions: Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation, EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma, Not Otherwise Specified, Large B-Cell Lymphoma With IRF4 Rearrangement, Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements, Recurrent Intravascular Large B-Cell Lymphoma, Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma, Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma, Recurrent Transformed B-Cell Non-Hodgkin Lymphoma, Refractory Aggressive B-Cell Non-Hodgkin Lymphoma, Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements, Refractory Intravascular Large B-Cell Lymphoma, Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma, Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma, Refractory Transformed B-Cell Non-Hodgkin Lymphoma
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Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)
NCT03773406
Recruiting
Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing. The ramifications of aphasia extend beyond language impairment to negatively impacting a person's social, vocational, and recreational activities. Currently, the most effective way to treat aphasia is with speech-language therapy (SLT). However, even if SLT is intensive, per... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/24/2022
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Aphasia
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Noninvasive Brain Stimulation for Diabetic Neuropathic Pain
NCT05469074
Recruiting
This is an investigator-initiated study that is in the funding range for a grant from the NIH. This study is testing the possibility that non-invasive brain stimulation (ESSTim) would be superior to sham in the treatment of pain secondary to diabetic neuropathy.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
07/19/2022
Locations: University of Illinois Health/ University of Illinois at Chicago, Hinsdale, Illinois
Conditions: Diabetic Neuropathies, Chronic Pain
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Integrating a Suite of Mental Health Apps for Depression in a Healthcare Setting
NCT05274620
Recruiting
The purpose of this study is to evaluate the implementation of IntelliCare as a frontline intervention within health care settings.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/18/2022
Locations: Northwestern Medicine Dept of Psychiatry, Chicago, Illinois
Conditions: Depression, Anxiety
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Defining Beef and Meal Frequency as Key Components of a Healthy Eating Pattern for Muscle Health and Wellbeing
NCT04232254
Recruiting
Adopting a healthy eating pattern is important for meeting dietary recommendations and weight management. Although less clear, it seems reasonable to assume that the eating patterns we typically follow can also affect our psychological wellbeing. As such, healthy eating patterns are often adapted to suit one's personal preference. For example, many people choose to follow a vegetarian-style eating pattern whereby meat, poultry, and seafood are excluded from the diet. However, current research su... Read More
Gender:
All
Ages:
Between 20 years and 40 years
Trial Updated:
07/18/2022
Locations: Freer Hall, Urbana, Illinois
Conditions: Meal Frequency, Dietary Habits, Muscle Protein Synthesis
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Evaluate the Safety and Efficacy of ON101 Cream for the Treatment of Chronic Diabetic Foot Ulcers
NCT04962139
Recruiting
The primary efficacy endpoint for this study is the proportion of subjects with complete closure of Target Ulcer during the 20-week Treatment Phase, which is assessed by the blinded independent evaluator.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/15/2022
Locations: Oneness Investigational Site, Mount Prospect, Illinois
Conditions: Chronic Diabetic Foot Ulcers
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BUILT Family Lifestyle Program for Children With ADHD
NCT05464056
Recruiting
The investigators have developed BUILT in hopes of empowering families to adopt and sustain healthy food, sleep, and exercise routines that optimize child focus, attention, and behavior. Over 8-weeks, the BUILT program will explore what science says about the effects of sleep, nutrition, and exercise on brain development and behavior; investigate the food, sleep, and exercise routines of the world's best athletes and intellectuals; and experiment with home routines to find those that best fits w... Read More
Gender:
All
Ages:
Between 6 years and 12 years
Trial Updated:
07/14/2022
Locations: Chicago Park District, Chicago, Illinois
Conditions: Attention Deficit Hyperactivity Disorder
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Comparing Meniscal Repair Biologic Augmentation: Marrow Venting Procedure Versus PRP (MVP Trial)
NCT04775004
Recruiting
There are no current or past RCT comparing biologic augments for meniscal repair. There is good data supporting both the use of BMVP of the intercondylar notch and intra-articular PRP injections for augmentation of meniscal repair. However, the effectiveness of these augmentation methods with respect to each other has never been investigated. The knowledge gained will allow us to potentially influence and adapt protocols to treat this particular patient population. Additionally, resources availa... Read More
Gender:
All
Ages:
16 years and above
Trial Updated:
07/11/2022
Locations: University of Chicago Medicine, Chicago, Illinois
Conditions: Meniscal Tear
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The Mollie Study, a Study to Evaluate the Safety and Efficacy of the Mollie Medical Device
NCT05445115
Recruiting
Study to evaluate the use of a medical device in relieving collision dyspareunia
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/30/2022
Locations: Vero Clinics, Decatur, Illinois
Conditions: Dyspareunia
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