Massachusetts is currently home to 3149 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration
NCT04523194
Recruiting
The purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (OCT), computed tomography angiograms (CTA) and cardiac magnetic resonance imaging (CMR) for future studies. The main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.
Gender:
ALL
Ages:
All
Trial Updated:
11/25/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Atherosclerosis
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Cognitive Control to Boost Physical Activity Adherence
NCT06338774
Recruiting
This trial is designed to develop and test the efficacy of cognitive training strategies to improve self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle. The main questions it aims to answer are: * Can cognitive training designed to improve cognitive control improve physical activity adherence? * What are the psychological, physiological, cognitive, and sociodemographic factors that affect the impact of cognitive control on physical activity adher... Read More
Gender:
ALL
Ages:
Between 40 years and 65 years
Trial Updated:
11/23/2024
Locations: Center for Cognitive and Brain Health, Boston, Massachusetts
Conditions: Physical Inactivity
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The Role of Fiber in the Prevention and Treatment of Fecal Incontinence
NCT04806386
Recruiting
The purpose of this study is to determine the effect of fiber supplementation on the fecal metagenome and metabolome in relation to symptoms and anorectal physiology in post-menopausal women with irritable bowel syndrome with diarrhea suffering from liquid stool fecal incontinence (FI.)
Gender:
FEMALE
Ages:
Between 50 years and 90 years
Trial Updated:
11/23/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Fecal Incontinence, Irritable Bowel Syndrome With Diarrhea
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Motivation for Exercise: a Mood-Based Focus
NCT06706180
Recruiting
The goal of this study is to assess the effects of an exercise-related video on exercise motivation and adherence. Specifically, the researchers are studying whether an exercise-for-mood video increase levels of exercise motivation as compared to an exercise-for-fitness video.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Boston University, Boston, Massachusetts
Conditions: Exercise Motivation
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Working Memory Training for People Aging with HIV
NCT06699927
Recruiting
The present study investigates the feasibility of working memory training in people aging with HIV (PAWHIV). In a cross-over design this stage 1 feasibility trial, will evaluate acceptability, and estimate possible effect sizes related to working memory training by examining potential differential effects in PAWHIV and those aging without HIV. This project highlights the importance of tailored cognitive assessments and interventions, engaging with underrepresented communities to enhance inclusiv... Read More
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
11/22/2024
Locations: Northeastern University, Boston, Massachusetts
Conditions: Cognitive Change
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Clinical Feasibility Study to Evaluate the Safety and Performance of the Profound Matrix System
NCT06157567
Recruiting
This is a non-randomized, multi-center, open-label clinical trial evaluating clinical feasibility treatments with the Profound Matrix system.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/22/2024
Locations: Candela Institue for Excellence, Marlborough, Massachusetts
Conditions: Skin Laxity, Wrinkle, Skin Condition
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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer
NCT06103864
Recruiting
This is a Phase III, randomised, open-label, 3-arm, multicentre, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with investigator's choice chemotherapy in combination with pembrolizumab in participants with PD-L1 positive locally recurrent inoperable or metastatic TNBC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Research Site, Boston, Massachusetts
Conditions: Breast Cancer
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A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202
NCT06062420
Recruiting
The primary purpose of the study is to evaluate the antitumor activity and safety of novel immunotherapy combinations compared with dostarlimab in participants with Programmed death ligand 1 (PD-L1) positive Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: GSK Investigational Site, Boston, Massachusetts
Conditions: Neoplasms, Head and Neck
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Prehospital Telemedicine Feasibility/Acceptability Pilot
NCT05967624
Recruiting
Teleconsultation, or the use of video telecommunications technology to deliver expert recommendations for care remotely, has been used to improve the safety and quality of emergency care for children in hospital-based acute care settings by providing real-time access to remote pediatric physician experts. Whether extending teleconsultation as a patient safety intervention to emergency medical systems (EMS) outside hospitals can similarly benefit sick and injured children in the community is unkn... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
11/22/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Respiratory Distress Syndrome
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Effect of Physical Activity Pattern on Cardiometabolic Health
NCT05838508
Recruiting
The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: * complete 2 inpatient stays * perform moderate exercise * be provided with identical meals * have frequent blood draws * provide urine and saliva samples
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
11/22/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Life Style
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A Study of ZN-c3 in Patients With Ovarian Cancer
NCT04516447
Recruiting
This is a Phase 1b open-label, multicenter study, evaluating the safety, tolerability, preliminary clinical activity, pharmacokinetics (PK), and pharmacodynamics of ZN-c3 in combination with other drugs.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Site 0104, Boston, Massachusetts
Conditions: Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
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Molecular Genetic Mechanisms of Infantile Epilepsies and the Impact of Genetic Diagnosis
NCT06701084
Recruiting
The goal of this study is to discover new genetic causes of infantile epilepsies and evaluate the impact of these discoveries on infants with epilepsy and their families.
Gender:
ALL
Ages:
All
Trial Updated:
11/21/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Neonatal Epilepsy, Infantile Epilepsy
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