Massachusetts is currently home to 3150 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Boston, Worcester, Springfield and Burlington. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Working Memory Training for People Aging with HIV
NCT06699927
Recruiting
The present study investigates the feasibility of working memory training in people aging with HIV (PAWHIV). In a cross-over design this stage 1 feasibility trial, will evaluate acceptability, and estimate possible effect sizes related to working memory training by examining potential differential effects in PAWHIV and those aging without HIV. This project highlights the importance of tailored cognitive assessments and interventions, engaging with underrepresented communities to enhance inclusiv... Read More
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
11/22/2024
Locations: Northeastern University, Boston, Massachusetts
Conditions: Cognitive Change
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Clinical Feasibility Study to Evaluate the Safety and Performance of the Profound Matrix System
NCT06157567
Recruiting
This is a non-randomized, multi-center, open-label clinical trial evaluating clinical feasibility treatments with the Profound Matrix system.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/22/2024
Locations: Candela Institue for Excellence, Marlborough, Massachusetts
Conditions: Skin Laxity, Wrinkle, Skin Condition
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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer
NCT06103864
Recruiting
This is a Phase III, randomised, open-label, 3-arm, multicentre, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with investigator's choice chemotherapy in combination with pembrolizumab in participants with PD-L1 positive locally recurrent inoperable or metastatic TNBC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Research Site, Boston, Massachusetts
Conditions: Breast Cancer
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A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202
NCT06062420
Recruiting
The primary purpose of the study is to evaluate the antitumor activity and safety of novel immunotherapy combinations compared with dostarlimab in participants with Programmed death ligand 1 (PD-L1) positive Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: GSK Investigational Site, Boston, Massachusetts
Conditions: Neoplasms, Head and Neck
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Prehospital Telemedicine Feasibility/Acceptability Pilot
NCT05967624
Recruiting
Teleconsultation, or the use of video telecommunications technology to deliver expert recommendations for care remotely, has been used to improve the safety and quality of emergency care for children in hospital-based acute care settings by providing real-time access to remote pediatric physician experts. Whether extending teleconsultation as a patient safety intervention to emergency medical systems (EMS) outside hospitals can similarly benefit sick and injured children in the community is unkn... Read More
Gender:
ALL
Ages:
17 years and below
Trial Updated:
11/22/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Respiratory Distress Syndrome
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Effect of Physical Activity Pattern on Cardiometabolic Health
NCT05838508
Recruiting
The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: * complete 2 inpatient stays * perform moderate exercise * be provided with identical meals * have frequent blood draws * provide urine and saliva samples
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
11/22/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Life Style
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A Study of ZN-c3 in Patients With Ovarian Cancer
NCT04516447
Recruiting
This is a Phase 1b open-label, multicenter study, evaluating the safety, tolerability, preliminary clinical activity, pharmacokinetics (PK), and pharmacodynamics of ZN-c3 in combination with other drugs.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Site 0104, Boston, Massachusetts
Conditions: Solid Tumor, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
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Molecular Genetic Mechanisms of Infantile Epilepsies and the Impact of Genetic Diagnosis
NCT06701084
Recruiting
The goal of this study is to discover new genetic causes of infantile epilepsies and evaluate the impact of these discoveries on infants with epilepsy and their families.
Gender:
ALL
Ages:
All
Trial Updated:
11/21/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Neonatal Epilepsy, Infantile Epilepsy
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Investigating the Effects of Tube Feeds on Glycemia and Sleep in Adults With Cystic Fibrosis-Related Diabetes
NCT06700889
Recruiting
The goal of this at-home, remote study is to understand how tube feeding affects blood sugars and sleep in adults living with Cystic Fibrosis Related Diabetes (CFRD).
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
11/21/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cystic Fibrosis Related Diabetes, Hyperglycaemia, Insomnia, Cardiometabolic Diseases, Circadian Rhythm Disorders
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A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)
NCT06526923
Recruiting
This is a Phase 1/2 multicenter, open-label, single dose trial of SP-101 investigational gene therapy in adults with CF who are ineligible for or intolerant to CFTR modulator therapy.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/21/2024
Locations: Boston Children's Hospital, Brigham & Women's Hospital, Boston, Massachusetts
Conditions: Cystic Fibrosis
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Mobile Application to Improve Health-Related Outcomes in Patients With Advanced Lung Cancer
NCT06427954
Recruiting
Multi-site randomized trial of the THRIVE digital health application versus usual care to evaluate the effect of THRIVE on quality of life (QOL), physical and psychological symptoms, coping, and self-efficacy in 250 patients with newly diagnosed advanced lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer
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A Text- and Audio-based Intervention to Promote Physical Activity in Midlife
NCT06172933
Recruiting
This is a randomized, controlled pilot trial (N=30) to examine the feasibility, acceptability, and preliminary efficacy of the Move with Meaning program, an 8- week, text message- and audio-based intervention to promote physical activity in midlife adults.
Gender:
ALL
Ages:
Between 45 years and 64 years
Trial Updated:
11/21/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Middle Aged
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